Olivry T, DeBoer DJ, Griffin CE, Halliwell RE, Hill PB, Hillier A, et al. The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet Immunol Immunopathol. 2001;81(3-4):143–6.
Article
CAS
PubMed
Google Scholar
Marsella R, Olivry T, Carlotti DN, International Task Force on Canine Atopic Dermatitis. Current evidence of skin barrier dysfunction in human and canine atopic dermatitis. Vet Dermatol. 2011;22(3):239–48.
Article
PubMed
Google Scholar
Bieber T. Atopic dermatitis. N Engl J Med. 2008;358:1483–94.
Article
CAS
PubMed
Google Scholar
Nuttall TJ, Knight PA, McAleese SM, Lamb JR, Hill PB. Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. Clin Exp Allergy. 2002;32(5):789–95.
Article
CAS
PubMed
Google Scholar
Schlotter YM, Rutten VP, Riemers FM, Knol EF, Willemse T. Lesional skin in atopic dogs shows a mixed Type-1 and Type-2 immune responsiveness. Vet Immunol Immunopathol. 2011;143(1-2):20–6. doi:10.1016/j.vetimm.2011.05.025.
Article
CAS
PubMed
Google Scholar
Martinez GJ, Nurieva RI, Yang XO, Dong C. Regulation and function of proinflammatory TH17 cells. Ann N Y Acad Sci. 2008;1143:188–211.
Article
CAS
PubMed
Google Scholar
Jutel M, Akdis CA. T-cell subset regulation in atopy. Curr Allergy Asthma Rep. 2011;11(2):139–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hennino A, Jean-Decoster C, Giordano-Labadie F, Debeer S, Vanbervliet B, Rozières A, Schmitt AM, Nicolas JF. CD8+ T cells are recruited early to allergen exposure sites in atopy patch test reactions in human atopic dermatitis. J Allergy Clin Immunol. 2011;127(4):1064–7. doi:10.1016/j.jaci.2010.11.022.
Article
CAS
PubMed
Google Scholar
Olivry T, Naydan DK, Moore PF. Characterization of the cutaneous inflammatory infiltrate in canine atopic dermatitis. Am J Dermatopathol. 1997;19:477–86.
Article
CAS
PubMed
Google Scholar
Sinke JD, Thepen T, Bihari IC, Rutten VP, Willemse T. Immunophenotyping of skininfiltrating T-cell subsets in dogs with atopic dermatitis. Vet Immunol Immunopathol. 1997;57:13–23.
Article
CAS
PubMed
Google Scholar
Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol. 2005;116(5):961–8.
Article
CAS
PubMed
Google Scholar
Palomares O, Yaman G, Azkur AK, Akkoc T, Akdis M, Akdis CA. Role of Treg in immune regulation of allergic diseases. Eur J Immunol. 2010;40(5):1232–40.
Article
CAS
PubMed
Google Scholar
Fujita H, Soyka MB, Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. Clin Transl Allergy. 2012;2(1):2. doi:10.1186/2045-7022-2-2.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wisniewski J, Agrawal R, Woodfolk JA. Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts. Clin Exp Allergy. 2013;43(2):164–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Merryman-Simpson AE, Wood SH, Fretwell N, Jones PG, McLaren WM, McEwan NA, et al. Gene (mRNA) expression in canine atopic dermatitis: microarray analysis. Vet Dermatol. 2008;19(2):59–66.
Article
PubMed
Google Scholar
Plager DA, Torres SM, Koch SN, Kita H. Gene transcription abnormalities in canine atopic dermatitis and related human eosinophilic allergic diseases. Vet Immunol Immunopathol. 2012;149(1-2):136–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schamber P, Schwab-Richards R, Bauersachs S, Mueller RS. Gene expression in the skin of dogs sensitized to the house dust mite Dermatophagoides farinae. G3 (Bethesda). 2014;4(10):1787–95.
Article
CAS
Google Scholar
Nikitin A, Egorov S, Daraselia N, Mazo I. Pathway studio--the analysis and navigation of molecular networks. Bioinformatics. 2003;19(16):2155–7.
Article
CAS
PubMed
Google Scholar
Schmitz S, Garden OA, Werling D, Allenspach K. Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease. Vet Immunol Immunopathol. 2012;146(1):87–91.
Article
CAS
PubMed
Google Scholar
Brinkhof B, Spee B, Rothuizen J, Penning LC. Development and evaluation of canine reference genes for accurate quantification of gene expression. Anal Biochem. 2006;356(1):36–43.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–8.
Article
CAS
PubMed
Google Scholar
Hennino A, Vocanson M, Toussaint Y, et al. Skin-infiltrating CD8 T cells initiate atopic dermatitis lesions. J Immunol. 2007;178:5571–7.
Article
CAS
PubMed
Google Scholar
Stock P, Kallinich T, Akbari O, Quarcoo D, Gerhold K, Wahn U, Umetsu DT, et al. CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation. Eur J Immunol. 2004;34(7):1817–27.
Article
CAS
PubMed
Google Scholar
Tarpataki N, Terenyi M, Nagy SZ. Changes in the CD4/CD8-positive T lymphocyte ratio in the blood of atopic and non-atopic dogs. Special Issue: 7th World Congress of Veterinary Dermatology, July 24–28, 2012, Vancouver, Canada July 2012. Vet Dermatol. 2012;23 Suppl 1:58. doi:10.1111/j.1365-3164.2012.01059.x. abstract.
Google Scholar
Taszkun I. Expression of CD3, CD4, CD8, CD21, and MHC II lymphocyte antigens and serum IL-10 concentration in dogs with atopic dermatitis complicated by purulent dermatitis. Bull Vet Inst Pulawy. 2013;7:365–70.
Google Scholar
Chabanne L, Marchal T, Denerolle P, Magnol JP, Fournel C, Monier JC, Rigal D. Lymphocyte subset abnormalities in German shepherd dog pyoderma (GSP). Vet Immunol Immunopathol. 1995;49:189–98.
Article
CAS
PubMed
Google Scholar
Pinheiro D, Singh Y, Grant CR, Appleton RC, Sacchini F, Walker KR, et al. Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog. Immunology. 2011;132(1):111–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hauck V, Hügli P, Meli ML, Rostaher A, Fischer N, Hofmann-Lehmann R, Favrot C. Increased numbers of FoxP3-expressing CD4+ CD25+ regulatory T cells in peripheral blood from dogs with atopic dermatitis and its correlation with disease severity. Vet Dermatol. 2016;27(1):26–e9. doi:10.1111/vde.12279.
Article
PubMed
Google Scholar
Beccati M, Martini V, Comazzi S, Fanton N, Cornegliani L. Lymphocyte subpopulations and Treg cells in dogs with atopic dermatitis receiving ciclosporin therapy: a prospective study. Vet Dermatol. 2016;27(1):17–e5. doi:10.1111/vde.12277.
Article
PubMed
Google Scholar
Bellinghausen I, König B, Böttcher I, Knop J, Saloga J. Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor. Immunology. 2005;116(1):103–11.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marsella R, Olivry T, Maeda S. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high-IgE beagles. Vet Dermatol. 2006;17(2):111–20.
Article
PubMed
Google Scholar
Wakugawa M, Hayashi K, Nakamura K, Tamaki KJ. Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. Dermatol Sci. 2001;25(2):116–26.
Article
CAS
Google Scholar
La Grutta S, Richiusa P, Pizzolanti G, Mattina A, Pajno GB, Citarrella R, et al. CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children. Allergy. 2005;60(3):391–5.
Article
PubMed
Google Scholar
Hayashiya S, Tani K, Morimoto M, Hayashi T, Hayasaki M, Nomura T, Une S, et al. Expression of T helper 1 and T helper 2 cytokine mRNAs in freshly isolated peripheral blood mononuclear cells from dogs with atopic dermatitis. J Vet Med A Physiol Pathol Clin Med. 2002;49(1):27–31.
Article
CAS
PubMed
Google Scholar
Pasparakis M, Alexopoulou L, Episkopou V, Kollias G. Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med. 1996;184(4):1397–411.
Article
CAS
PubMed
Google Scholar
Stanley AC, Lacy P. Pathways for cytokine secretion. Physiology (Bethesda). 2010;25(4):218–29.
Article
CAS
Google Scholar
Lin YL, Shieh CC, Wang JY. The functional insufficiency of human CD4 + CD25 high T-regulatory cells in allergic asthma is subjected to TNF-alpha modulation. Allergy. 2008;63(1):67–74.
Article
CAS
PubMed
Google Scholar
Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specifica-tion by the forkhead transcription factor foxp3. Immunity. 2005;22:329–41.
Article
CAS
PubMed
Google Scholar
Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci. 2008;1(13):1440–6.
Article
Google Scholar
Nandakumar S, Miller CW, Kumaraguru U. T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clin Mol Allergy. 2009;7:5. doi:10.1186/1476-7961-7-5.
Article
PubMed
PubMed Central
Google Scholar
Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J. IL-2 regulates FOXP3 expression in human CD4 + CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood. 2006;108(5):1571–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA. IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol. 2007;178:280.
Article
CAS
PubMed
Google Scholar
Yao Z, Kanno Y, Kerenyi M, Stephens G, Durant L, Watford WT, et al. Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood. 2007;109:4368–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Int Immunol. 2009;21(10):1105–11.
Article
CAS
PubMed
Google Scholar
Xie X, Stubbington MJ, Nissen JK, Andersen KG, Hebenstreit D, Teichmann SA, Betz AG. The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding. PLoS Genet. 2015;11(6):e1005251. doi:10.1371/journal.pgen.1005251. eCollection 2015.
Article
PubMed
PubMed Central
Google Scholar
Shevach EM. Mechanisms of Foxp3+ T regulatory cell-mediated suppression. Immunity. 2009;30(5):636–45.
Article
CAS
PubMed
Google Scholar
Moon BI, Kim TH, Seoh JY. Functional Modulation of Regulatory T Cells by IL-2. PLoS One. 2015;10(11):e0141864. doi:10.1371/journal.pone.0141864.
Article
PubMed
PubMed Central
Google Scholar
Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol. 2014;133(3):621–31.
Article
CAS
PubMed
Google Scholar
Keppel KE, Campbell KL, Zuckermann FA, Greeley EA, Schaeffer DJ, Husmann RJ. Quantitation of canine regulatory T cell populations, serum interleukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immunotherapy. Vet Immunol Immunopathol. 2008;123(3-4):337–44.
Article
CAS
PubMed
Google Scholar
Maeda S, Tsuchida H, Marsella R. Allergen challenge decreases mRNA expression of regulatory cytokines in whole blood of high-IgE beagles. Vet Dermatol. 2007;18(6):422–6.
Article
PubMed
Google Scholar
Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3 + CD4 + CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J Immunol. 2008;180:7112–6.
Article
CAS
PubMed
Google Scholar
Wahl SM, Vázquez N, Chen W. Regulatory T cells and transcription factors: gatekeepers in allergic inflammation. Curr Opin Immunol. 2004;16(6):768–74.
Article
CAS
PubMed
Google Scholar
Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med. 2004;10(10):1095–103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang Y, Matsuo H, Morita E. Increased production of vascular endothelial growth factor in the lesions of atopic dermatitis. Arch Dermatol Res. 2006;297:425–9.
Article
CAS
PubMed
Google Scholar
Koczy-Baron E, Jochem J, Kasperska-Zajac A. Increased plasma concentration of vascular endothelial growth factor in patients with atopic dermatitis and its relation to disease severity and platelet activation. Inflamm Res. 2012;61(12):1405–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen W, Wahl SM. TGF-beta: the missing link in CD4 + CD25+ regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev. 2003;14(2):85–9.
Article
CAS
PubMed
Google Scholar
Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W. TGF-beta 1 plays an important role in the mechanism of CD4 + CD25+ regulatory T cell activity in both humans and mice. J Immunol. 2004;172(2):834–42.
Article
CAS
PubMed
Google Scholar
Aki S, Yoshioka K, Okamoto Y, Takuwa N, Takuwa Y. Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells. J Biol Chem. 2015;290(10):6086–105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang N, Zhao B, Rasul A, Qin H, Li J, Li X. PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis. Cell Death Dis. 2013;4:e811. doi:10.1038/cddis.2013.33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Giguere V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR α, a novel family of orphan hormone nuclear receptors. Genes Dev. 1994;8:538–53.
Article
CAS
PubMed
Google Scholar
Jetten AM. Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism. Nucl Recept Signal. 2009;7:e003. doi:10.1621/nrs.07003.
PubMed
PubMed Central
Google Scholar
Du J, Huang C, Zhou B, Ziegler SF. Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3. J Immunol. 2008;180(7):4785–92.
Article
CAS
PubMed
Google Scholar
Dzhagalov I, Giguère V, He YW. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. J Immunol. 2004;173(5):2952–9.
Article
CAS
PubMed
Google Scholar
Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 2008;454(7202):350–2. doi:10.1038/nature07021.
Article
CAS
PubMed
PubMed Central
Google Scholar
Delerive P, Monté D, Dubois G, Trottein F, Fruchart-Najib J, Mariani J, Fruchart JC, Staels B. The orphan nuclear receptor ROR alpha is a negative regulator of the inflammatory response. EMBO Rep. 2001;2(1):42–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Farez MF, Mascanfroni ID, Méndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, et al. Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses. Cell. 2015;162(6):1338–52.
Article
CAS
PubMed
Google Scholar
Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007;109(8):3161–72.
Article
CAS
PubMed
Google Scholar
Wang L, Bastarache JA, Wickersham N, Fang X, Matthay MA, Ware LB. Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation. Am J Respir Cell Mol Biol. 2007;36(4):497–503. doi:10.1165/rcmb.2005-0425OC.
Article
CAS
PubMed
Google Scholar
Moxon CA, Heyderman RS, Wassmer SC. Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol. 2009;166(2):99–108.
Article
CAS
PubMed
PubMed Central
Google Scholar
Beinsberger J, Heemskerk JW, Cosemans JM. Chronic arthritis and cardiovascular disease: altered blood parameters give rise to a prothrombotic propensity. Semin Arthritis Rheum. 2014;44(3):345–52. doi:10.1016/j.semarthrit.2014.06.006.
Article
CAS
PubMed
Google Scholar
Rui L, Carter-Su C. Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2. Proc Natl Acad Sci U S A. 1999;96(13):7172–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
O’Brien KB, O’Shea JJ, Carter-Su C. SH2-B family members differentially regulate JAK family tyrosine kinases. J Biol Chem. 2002;277(10):8673–81.
Article
PubMed
Google Scholar