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230 result(s) for 'oncology' within BMC Veterinary Research

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  1. Mammary tumours are the most common malignancy diagnosed in female dogs and a significant cause of mortality and morbidity in this species. Carbohydrate antigen (CA) 15–3 is a mucinous glycoprotein aberrantly ove...

    Authors: Elisabetta Manuali, Antonio De Giuseppe, Francesco Feliziani, Katia Forti, Cristina Casciari, Maria Chiara Marchesi, Eugenio Pacifico, Karol M Pawłowski, Kinga Majchrzak and Magdalena Król
    Citation: BMC Veterinary Research 2012 8:86
  2. Cancer is a leading cause of mortality for both humans and dogs. As spontaneous canine cancers appear to be relevant models of human cancers, developing new therapeutic approaches could benefit both species. O...

    Authors: Jérémy Béguin, Virginie Nourtier, Murielle Gantzer, Sandrine Cochin, Johann Foloppe, Jean-Marc Balloul, Eve Laloy, Dominique Tierny, Bernard Klonjkowski, Eric Quemeneur, Christelle Maurey and Philippe Erbs
    Citation: BMC Veterinary Research 2020 16:307
  3. In male dogs, uroepithelial cancers include invasive urothelial carcinoma (iUC) and prostate carcinoma (PCA). The inability to distinguish iUC involving the prostate from PCA results in indiscriminate clinical...

    Authors: Matthew R. Berry, Bahaa A. Fadl-Alla, Jonathan Samuelson, Thomas J. Rosol and Timothy M. Fan
    Citation: BMC Veterinary Research 2022 18:441
  4. Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured, and median survival times are generally in the 12-month range. Novel approaches to treatmen...

    Authors: Douglas H. Thamm, Jenette K. Joseph, Barbara J. Rose, Travis K. Meuten and Kristen M. Weishaar
    Citation: BMC Veterinary Research 2020 16:97
  5. Myeloid derived suppressor cells (MDSCs) are a recently described population of immune cells that significantly contribute to the immunosuppression seen in cancer patients. MDSCs are one of the most important fac...

    Authors: Matthew Sherger, William Kisseberth, Cheryl London, Susan Olivo-Marston and Tracey L Papenfuss
    Citation: BMC Veterinary Research 2012 8:209
  6. Both human and veterinary cancer chemotherapy are undergoing a paradigm shift from a “one size fits all” approach to more personalized, patient-oriented treatment strategies. Personalized chemotherapy is dependen...

    Authors: Kristine Walters, Alessia Stornetta, Foster Jacobs, Peter W. Villalta, Maria Razzoli, Marianne Grant, Beshay Zordoky, Alessandro Bartolomucci, Antonella Borgatti and Silvia Balbo
    Citation: BMC Veterinary Research 2021 17:378
  7. α-Enolase (ENO1) is a key glycolytic enzyme implicated in the development of many human cancers including breast cancer. Increased expression of ENO1 has recently been reported in estrogen (ER)-positive human ...

    Authors: Pei-Yi Chu, Nicholas C Hsu, Albert T Liao, Neng-Yao Shih, Ming-Feng Hou and Chen-Hsuan Liu
    Citation: BMC Veterinary Research 2011 7:62
  8. Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chem...

    Authors: Angelo Ferrari, Claudio Petterino, Alessandra Ratto, Chiara Campanella, Roberto Wurth, Stefano Thellung, Guendalina Vito, Federica Barbieri and Tullio Florio
    Citation: BMC Veterinary Research 2012 8:27
  9. Bovine papillomaviruses (BPVs) types 1 and 2 are the only known papillomaviruses able to jump the species. In fact, BPVs 1/2 induce neoplasia in their natural bovine host but infection is also associated to ne...

    Authors: Gennaro Altamura, Maria Strazzullo, Annunziata Corteggio, Romina Francioso, Franco Roperto, Maurizio D'Esposito and Giuseppe Borzacchiello
    Citation: BMC Veterinary Research 2012 8:218
  10. Mast cell tumors (MCTs) are the most common skin tumors in dogs and exhibit variable biologic behavior. Mutations in the c-kit proto-oncogene are associated with the tumorigenesis of MCTs, resulting in growth fac...

    Authors: Charles HC Halsey, Daniel L Gustafson, Barbara J Rose, Amber Wolf-Ringwall, Robert C Burnett, Dawn L Duval, Anne C Avery and Douglas H Thamm
    Citation: BMC Veterinary Research 2014 10:105
  11. Doxorubicin (DOX) is widely used in both human and veterinary oncology although the onset of multidrug resistance (MDR...(20h) DOX at 12, 24 and 48 h of treatment. We assessed the uptake and subcellular distribut...

    Authors: Michela Levi, Roberta Salaroli, Federico Parenti, Raffaella De Maria, Augusta Zannoni, Chiara Bernardini, Cecilia Gola, Antonio Brocco, Asia Marangio, Cinzia Benazzi, Luisa Vera Muscatello, Barbara Brunetti, Monica Forni and Giuseppe Sarli
    Citation: BMC Veterinary Research 2021 17:30
  12. Cutaneous and subcutaneous neoplasms are highly prevalent in dogs, ranging from benign to highly aggressive and metastatic lesions. The diagnosis is obtained through histopathology, however it is an invasive t...

    Authors: Igor Cezar Kniphoff da Cruz, Rafael Kretzer Carneiro, Andrigo Barboza de Nardi, Ricardo Andrés Ramirez Uscategui, Eduarda Mazzardo Bortoluzzi and Marcus Antônio Rossi Feliciano
    Citation: BMC Veterinary Research 2022 18:10
  13. Capecitabine is an oral prodrug of the active metabolite 5-fluorouracil, which has been used effectively in human colorectal, head and neck, and mammary carcinomas. Capecitabine has several properties that mak...

    Authors: Sarah Wetzel, Janean Fidel, Dale Whittington and Nicolas F. Villarino
    Citation: BMC Veterinary Research 2024 20:36
  14. This study aimed to evaluate the relationship between the molecular phenotype of the primary mammary tumor and its related lymph node metastasis in the dog to develop prognostic-predictive models and targeted ...

    Authors: Germana Beha, Barbara Brunetti, Pietro Asproni, Luisa Vera Muscatello, Francesca Millanta, Alessandro Poli, Giuseppe Sarli and Cinzia Benazzi
    Citation: BMC Veterinary Research 2012 8:219
  15. In both women and female dogs, the most prevalent type of malignant neoplasm is the spontaneous mammary tumor. In dogs, half of these are malignant. The treatment of choice for the canine patients is surgical ...

    Authors: Karol M Pawłowski, Joanna Mucha, Kinga Majchrzak, Tomasz Motyl and Magdalena Król
    Citation: BMC Veterinary Research 2013 9:119
  16. Triple negative breast cancer (TNBC) in humans is defined by the absence of oestrogen receptor (ER), progesterone receptor (PR) and HER2 overexpression. Mammalian target of rapamycin (mTOR) is overexpressed in...

    Authors: Lorella Maniscalco, Yolanda Millán, Selina Iussich, Mauro Denina, Raquel Sánchez-Céspedes, Francesca Gattino, Bartolomeo Biolatti, Nobuo Sasaki, Takayuki Nakagawa, Maria Flavia Di Renzo, Juana Martín de las Mulas and Raffaella De Maria
    Citation: BMC Veterinary Research 2013 9:80
  17. Cutaneous squamous cell carcinoma of the nasal planum in cats is a common indication for antitumor treatment such as external beam radiation therapy. Curative-intent radiation therapy has been described as a v...

    Authors: Evgeniya Gasymova, Valeria Meier, Franco Guscetti, Simona Cancedda, Malgorzata Roos and Carla Rohrer Bley
    Citation: BMC Veterinary Research 2017 13:86
  18. Effective treatment options for inoperable, metastatic, or recurrent canine pheochromocytomas are lacking. In humans, specific germline mutations exist that drive the development of pheochromocytomas. Pharmace...

    Authors: Margaret L. Musser, Kathryn L. Taikowski, Chad M. Johannes and Philip J. Bergman
    Citation: BMC Veterinary Research 2018 14:272
  19. Multiple myeloma (MM) is an important human and canine cancer for which novel therapies remain necessary. VDC-1101 (formerly GS-9219), a novel double prodrug of the anti-proliferative nucleotide analog 9-(2-ph...

    Authors: Douglas H Thamm, David M Vail, Ilene D Kurzman, Darius Babusis, Adrian S Ray, Noel Sousa-Powers and Daniel B Tumas
    Citation: BMC Veterinary Research 2014 10:30
  20. Spontaneous gastrointestinal neoplasms in non-human primates are commonly seen in aged individuals. Due to genetic similarities between human and non-human primates, scientists have shown increasing interest in t...

    Authors: Mónica Aristizabal-Arbelaez, Julian Mejía-Restrepo, Mauricio Montoya-Flórez, Fabrizio Grandi and Francisco Pedraza-Ordóñez
    Citation: BMC Veterinary Research 2012 8:97
  21. Lymphatic neoplasia may occur in various types, such as lymphoma, lymphosarcoma, lympholeukemia, and plasmacytoid leukemia. Lymphoma, defined as a malignant tumour of lymphoid tissue, has been found in a numbe...

    Authors: Hooman Rahmati-Holasoo, Sara Shokrpoor, Amin Marandi, Niyousha Torjani and Hosseinali Ebrahimzadeh Mousavi
    Citation: BMC Veterinary Research 2023 19:67
  22. Cancer is a major cause of death in domestic animals. Furthermore, many forms of pet neoplasm resemble that of their human counterparts in biologic behaviour, pathologic expression, and recognised risk factors.

    Authors: Marta Vascellari, Elisa Baioni, Giuseppe Ru, Antonio Carminato and Franco Mutinelli
    Citation: BMC Veterinary Research 2009 5:39
  23. Tumescent anaesthesia (TA) is a widely used technique in oncologic surgeries necessitating large resection margins. This technique produces transoperative and postoperative analgesia, reduces surgical bleeding...

    Authors: Leonardo de Freitas Guimaraes Arcoverde Credie, Stelio Pacca Loureiro Luna, Fabio Futema, Luciano Cacciari Baruffaldi Almeida da Silva, Giancarlo Bressane Gomes, Jaqueline Neratika Negrette Garcia and Lidia Raquel de Carvalho
    Citation: BMC Veterinary Research 2013 9:178
  24. Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of endothelial origin that closely resembles visceral angiosarcoma in humans, both clinically and histopathologically. Currently there is an ...

    Authors: Chinatsu Mukai, Eunju Choi, Kelly L. Sams, Elena Zu Klampen, Lynne Anguish, Brooke A. Marks, Edward J. Rice, Zhong Wang, Lauren A. Choate, Shao-Pei Chou, Yukinari Kato, Andrew D. Miller, Charles G. Danko and Scott A. Coonrod
    Citation: BMC Veterinary Research 2020 16:206
  25. Communication skills are a necessary competency in veterinary medicine, and shared decision-making (SDM) between practitioners and patients is becoming increasingly important in veterinary practice as in human...

    Authors: Yuma Ito, Hirono Ishikawa, Asuka Suzuki and Mio Kato
    Citation: BMC Veterinary Research 2022 18:296
  26. While lymphadenectomy of metastatic lymph nodes (LNs) has been associated with improved outcome, the clinical utility of prophylactic lymphadenectomy in dogs with stage I cutaneous mast cell tumors (cMCTs) rem...

    Authors: Silvia Sabattini, Matti Kiupel, Riccardo Finotello, Damiano Stefanello, Eugenio Faroni, Walter Bertazzolo, Ugo Bonfanti, Antonella Rigillo, Sara Del Magno, Armando Foglia, Luca Aresu, Matteo Gambini, Mario Caniatti and Laura Marconato
    Citation: BMC Veterinary Research 2021 17:331
  27. Harmonized institutional processes and reviewer training are vital to maintain integrity and ethical rigor of the veterinary clinical research pipeline and are a prerequisite to future work that might establis...

    Authors: S. A. Moore, A. O’Kell, H. Borghese, R. Garabed, H. O’Meara and P. Baneux
    Citation: BMC Veterinary Research 2021 17:83
  28. Bibliographic data can be used to map the research quality and productivity of a discipline. We hypothesized that bibliographic data would identify geographic differences in research capacity, species speciali...

    Authors: Mary M Christopher and Ana Marusic
    Citation: BMC Veterinary Research 2013 9:115
  29. Nucleosomes consist of DNA wrapped around a histone octamer core like thread on a spool to condense DNA as chromatin into chromosomes. Diseases such as cancer or inflammation lead to cell death, chromatin frag...

    Authors: Heather Wilson-Robles, Tasha Miller, Jill Jarvis, Jason Terrell, Theresa Kathleen Kelly, Thomas Bygott and Mhammed Bougoussa
    Citation: BMC Veterinary Research 2021 17:231
  30. The use of nutraceuticals is gaining in popularity in human and canine oncology with a relatively limited understanding of the ... the vastly different tumor types seen in canine oncology. We have previously show...

    Authors: Corri B. Levine, Julie Bayle, Vincent Biourge and Joseph J. Wakshlag
    Citation: BMC Veterinary Research 2017 13:388
  31. Low-grade alimentary lymphoma (LGAL) is characterised by the infiltration of neoplastic T-lymphocytes, typically in the small intestine. The incidence of LGAL has increased over the last ten years and it is no...

    Authors: Mathieu V Paulin, Lucile Couronné, Jérémy Beguin, Sophie Le Poder, Maxence Delverdier, Marie-Odile Semin, Julie Bruneau, Nadine Cerf-Bensussan, Georgia Malamut, Christophe Cellier, Ghita Benchekroun, Laurent Tiret, Alexander J German, Olivier Hermine and Valérie Freiche
    Citation: BMC Veterinary Research 2018 14:306
  32. Canine cancer registry data can be put to good use in epidemiological studies. Quantitative comparison of tumour types may reveal unusual cancer frequencies, providing directions for research and generation of...

    Authors: Elisa Baioni, Eugenio Scanziani, Maria Claudia Vincenti, Mauro Leschiera, Elena Bozzetta, Marzia Pezzolato, Rosanna Desiato, Silvia Bertolini, Cristiana Maurella and Giuseppe Ru
    Citation: BMC Veterinary Research 2017 13:203
  33. Radiation therapy is a palliative treatment modality for canine osteosarcoma, with transient improvement in analgesia observed in many cases. However there is room for improvement in outcome for these patients...

    Authors: Fernanda B. Mantovani, Jodi A. Morrison and Anthony J. Mutsaers
    Citation: BMC Veterinary Research 2016 12:82
  34. Additive manufacturing has allowed for the creation of a patient-specific custom solution that can resolve many of the limitations previously reported for canine cranioplasty. The purpose of this pilot study w...

    Authors: J. James, M. L. Oblak, A. R. zur Linden, F. M. K. James, J. Phillips and M. Parkes
    Citation: BMC Veterinary Research 2020 16:180
  35. Marek’s disease (MD) is a chicken neoplastic disease, which brings huge economic losses to the global poultry industry. The wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, prom...

    Authors: Huixia Zhang, Mengda Liu, Hui Zhang, Shengliang Cao, Yue Li, Shengnan Jiang, Yinuo Song and Sidang Liu
    Citation: BMC Veterinary Research 2020 16:303
  36. Autophagy is a self-catabolic mechanism that degrades unnecessary cellular components through lysosomal enzymes. Beclin-1, an autophagy-related protein, establishes the first connection between autophagy and t...

    Authors: Jing-Lan Liu, Kai-Chian Chang, Chun-Chih Lo, Pei-Yi Chu and Chen-Hsuan Liu
    Citation: BMC Veterinary Research 2013 9:75
  37. Malignant melanoma in dogs is considered to be largely resistant to conventional chemotherapy, although responses to carboplatin have been documented. Invasion and early metastasis are common features of certa...

    Authors: Sarah Bernard, Andrew C. Poon, Peyton M. Tam and Anthony J. Mutsaers
    Citation: BMC Veterinary Research 2021 17:382
  38. Canine hemangiosarcoma (HSA) is an aggressive cancer arising from multipotential bone marrow-derived stem cells. Anthracycline chemotherapy drugs have been the mainstay adjuvant chemotherapy following surgery ...

    Authors: Michael D. Lucroy, Ryan M. Clauson, Mark A. Suckow, Ferris El-Tayyeb and Ashley Kalinauskas
    Citation: BMC Veterinary Research 2020 16:447
  39. Radiotherapy (RT) is currently considered the treatment of choice for presumed canine intracranial gliomas. However, variable therapeutic responses are described, due to heterogeneous populations and different...

    Authors: M. Debreuque, P. De Fornel, I. David, F. Delisle, M. N. Ducerveau, P. Devauchelle and J. L. Thibaud
    Citation: BMC Veterinary Research 2020 16:412
  40. Transmissible venereal tumors (TVT) are a wide range of canine tumors for which there are no effective markers to monitor the therapeutic response in real-time. Circulating biomarkers can be valuable in early ...

    Authors: Mona Mohamadzaheri, Hadi Cheraghi, Darioush Shirani and Ali Hatamkhani
    Citation: BMC Veterinary Research 2022 18:76
  41. The molecular-based classification of canine mammary carcinomas (CMCs) has been the focus of much current research. Both in canines and humans, the triple-negative (TN) molecular subtype of mammary cancer is d...

    Authors: R. Sánchez-Céspedes, M. D. Fernández-Martínez, A. I. Raya, C. Pineda, I. López and Y. Millán
    Citation: BMC Veterinary Research 2021 17:197
  42. Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied ...

    Authors: Robert Klopfleisch, Anja Meyer, Patricia Schlieben, Angelika Bondzio, Chris Weise, Dido Lenze, Michael Hummel, Ralf Einspanier and Achim D Gruber
    Citation: BMC Veterinary Research 2012 8:96
  43. Chemotherapeutic options for the treatment of canine lymphoma have not changed in several decades necessitating the identification of new therapeutics to improve patient outcome. KPT-335 (verdinexor) is a nove...

    Authors: Abbey R. Sadowski, Heather L. Gardner, Antonella Borgatti, Heather Wilson, David M. Vail, Joshua Lachowicz, Christina Manley, Avenelle Turner, Mary K. Klein, Angharad Waite, Alexandra Sahora and Cheryl A. London
    Citation: BMC Veterinary Research 2018 14:250
  44. Dogs suffer from spontaneous tumors which may be amenable to therapies developed for human cancer patients, and dogs may serve as large-animal cancer models. A non-pathogenic Semliki Forest virus vector VA7-EG...

    Authors: Karoliina P. M. Autio, Janne J. Ruotsalainen, Marjukka O. Anttila, Minna Niittykoski, Matti Waris, Akseli Hemminki, Markus J. V. Vähä-Koskela and Ari E. Hinkkanen
    Citation: BMC Veterinary Research 2015 11:170
  45. A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, the cost and time requirements associated with this protocol are not feasi...

    Authors: Sami Al-Nadaf, Robert B. Rebhun, Kaitlin M. Curran, Rachel O. Venable, Katherine A. Skorupski, Jennifer L. Willcox and Jenna H. Burton
    Citation: BMC Veterinary Research 2018 14:356
  46. Canine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression...

    Authors: Heather Wilson-Robles, Kelli Franks, Roy Pool and Tasha Miller
    Citation: BMC Veterinary Research 2019 15:357

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