Maes D, Segales J, Meyns T, Sibila M, Pieters M, Haesebrouck F. Control of Mycoplasma hyopneumoniae infections in pigs. Vet Microbiol. 2008;126:297–309.
Article
CAS
PubMed
Google Scholar
Maes D, Deluyker H, Verdonck M, Castryck F, Miry C, Vrijens B, et al. Effect of vaccination against Mycoplasma hyopneumoniae in pig herds with an all-in/all-out production system. Vaccine. 1999;17:1024–34.
Article
CAS
PubMed
Google Scholar
Villarreal I, Meyns T, Dewulf J, Vranckx K, Calus D, Pasmans F, et al. The effect of vaccination on the transmission of Mycoplasma hyopneumoniae in pigs under field conditions. Vet J. 2011;188:48–52.
Article
CAS
PubMed
Google Scholar
Vranckx K, Maes D, Calus D, Villarreal I, Pasmans F, Haesebrouck F. Multiple locus variable number of tandem repeats analysis is a suitable tool for the differentiation of Mycoplasma hyopneumoniae strains without cultivation. J Clin Microbiol. 2011;49:2020–3.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vranckx K, Maes D, Del Pozo SR, Pasmans F, Haesebrouck F. A longitudinal study of the diversity and dynamics of Mycoplasma hyopneumoniae infections in pig herds. Vet Microbiol. 2011;156:315–21.
Article
PubMed
Google Scholar
Michiels A, Vranckx K, Piepers S, Del Pozo SR, Arsenakis I, Boyen F, et al. Impact of diversity of Mycoplasma hyopneumoniae strains on lung lesions in slaughter pigs. Vet Res. 2017;48:1–14.
Article
Google Scholar
Pointon AMD, Byrt D, Heap P. Effect of enzootic pneumonia of pigs on growth performance. Aust Vet J. 1985;62:13–8.
CAS
PubMed
Google Scholar
Haesebrouck F, Pasmans F, Chiers K, Maes D, Ducatelle R, Decostere A. Efficacy of vaccines against bacterial diseases in swine: what can we expect? Vet Microbiol. 2004;100:255–68.
Article
CAS
PubMed
Google Scholar
Martelli P, Saleri R, Cavalli V, De Angelis E, Ferrari L, Benetti M, et al. Systemic and local immune response in pigs intradermally and intramuscularly injected with inactivated Mycoplasma hyopneumoniae vaccines. Vet Microbiol. 2014;168:357–64.
Article
CAS
PubMed
Google Scholar
Jensen CS, Ersbøll AK, Nielsen JP. A meta-analysis comparing the effect of vaccines against Mycoplasma hyopneumoniae on daily weight gain in pigs. Prev Vet Med. 2002;54:265–78.
Article
CAS
PubMed
Google Scholar
Kyriakis SC, Alexopoulos C, Vlemmas J, Sarris K, Lekkas S, Koutsoviti-Papadopoulou M, et al. Field study on the efficacy of two different vaccination schedules with HYORESP® in a Mycoplasma hyopneumoniae-infected commercial pig unit. J Vet Med. 2001;48:675–84.
Article
CAS
Google Scholar
Meyns T, Dewulf J, de Kruif A, Calus D, Haesebrouck F, Maes D. Comparison of transmission of Mycoplasma hyopneumoniae in vaccinated and non-vaccinated populations. Vaccine. 2006;24:7081–6.
Article
CAS
PubMed
Google Scholar
Martelli P, Terreni M, Guazzetti S, Cavirani S. Antibody response to Mycoplasma hyopneumoniae infection in vaccinated pigs with or without maternal antibodies induced by sow vaccination. J Vet Med. 2006;53:229–33.
Article
CAS
Google Scholar
Goodwin RFW, Whittlestone P. Production of enzootic pneumonia in pigs with an agent grown in tissue culture from the natural disease. Br J Exp Pathol. 1963;44:291–9.
CAS
PubMed
PubMed Central
Google Scholar
Marchioro SB, Maes D, Haesebrouck F, Dellagostin OA. Immune responses following vaccination of pigs and mice against Mycoplasma hyopneumoniae. Ghent: Ghent Univeristy; 2013.
Vicca J, Stakenborg T, Maes D, Butaye P, Peeters J, de Kruif A, et al. Evaluation of virulence of Mycoplasma hyopneumoniae field isolates. Vet Microbiol. 2003;97:177–90.
Article
CAS
PubMed
Google Scholar
Halbur PG, Paul PS, Meng XJ, Lum MA, Andrews JJ, Rathje JA. Comparative pathogenicity of nine US porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model. J Vet Diagn Investig. 1996;8:11–20.
Article
CAS
Google Scholar
Del Pozo SR, Sierens A, Marchioro SB, Vangroenweghe F, Jourquin J, Labarque G, et al. Efficacy of early Mycoplasma hyopneumoniae vaccination against mixed respiratory disease in older fattening pigs. Vet Rec. 2014;174
Hannan PC, Bhogal BS, Fish JP. Tylosin tartrate and tiamutilin effects on experimental piglet pneumonia induced with pneumonic pig lung homogenate containing mycoplasmas, bacteria and viruses. Res Vet Sci. 1982;33:76–88.
CAS
PubMed
Google Scholar
Morris C, Gardner I, Hietala S, Carpenter T, Anderson R, Parker K. Seroepidemiologic study of natural transmission of Mycoplasma hyopneumoniae in a swine herd. Prev Vet Med. 1995;21:323–37.
Article
Google Scholar
Rasband WS. ImageJ U. S. National Institutes of Health, Bethesda. 1997–2016. https://imagej.nih.gov/ij/. Accessed 17 Aug 2017.
Marois C, Dory D, Fablet C, Madec F, Kobisch M. Development of a quantitative real-time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs. J Appl Microbiol. 2010;108:1523–33.
Article
CAS
PubMed
Google Scholar
Bereiter M, Young TF, Joo HS, Ross RF. Evaluation of the ELISA and comparison to the complement-fixation test and radial immunodiffusion enzyme assay for detection of antibodies against Mycoplasma hyopneumoniae in swine serum. Vet Microbiol. 1990;25:177–92.
Article
CAS
PubMed
Google Scholar
Marchioro SB, Maes D, Flahou B, Pasmans F, Del Pozo SR, Vranckx K, et al. Local and systemic immune responses in pigs intramuscularly injected with an inactivated Mycoplasma hyopneumoniae vaccine. Vaccine. 2013;31:1305–11.
Article
CAS
PubMed
Google Scholar
Villarreal I, Maes D, Vranckx K, Calus D, Pasmans F, Haesebrouck F. Effect of vaccination of pigs against experimental infection with high and low virulence Mycoplasma hyopneumoniae strains. Vaccine. 2011;29:1731–5.
Article
CAS
PubMed
Google Scholar
Team RC. R: A language and environment for statistical computing. Vienna, Austria. 2016. URL https://www.R-project.org/. Accessed 17 Aug 2017.
Stakenborg T, Vicca J, Butaye P, Maes D, Peeters J, de Kruif A, et al. The diversity of Mycoplasma hyopneumoniae within and between herds using pulsed-field gel electrophoresis. Vet Microbiol. 2005;109:29–35.
Article
CAS
PubMed
Google Scholar
Calus D, Baele M, Meyns T, de Kruif A, Butaye P, Decostere A, et al. Protein variability among Mycoplasma hyopneumoniae isolates. Vet Microbiol. 2007;120:284–91.
Article
CAS
PubMed
Google Scholar
Stakenborg T, Vicca J, Maes D, Peeters J, de Kruif A, Haesebrouck F, et al. Comparison of molecular techniques for the typing of Mycoplasma hyopneumoniae isolates. J Microbiol Methods. 2006;66:263–75.
Article
CAS
PubMed
Google Scholar
Moorkamp L, Nathues H, Spergser J, Tegeler R, Grosse Beilage E. Detection of respiratory pathogens in porcine lung tissue and lavage fluid. Vet J. 2008;175:273–5.
Article
PubMed
Google Scholar
Arsenakis I, Panzavolta L, Michiels A, Del Pozo SR, Boyen F, Haesebrouck F, et al. Efficacy of Mycoplasma hyopneumoniae vaccination before and at weaning against experimental challenge infection in pigs. BMC Vet Res. 2016;12:1–7.
Article
Google Scholar
Marchioro SB, Del Pozo SR, Michiels A, Haesebrouck F, Conceição FR, Dellagostin OA, et al. Immune responses of a chimaeric protein vaccine containing Mycoplasma hyopneumoniae antigens and LTB against experimental M. hyopneumoniae infection in pigs. Vaccine. 2014;6:4689–94.
Article
Google Scholar
Del Pozo SR, Thiry J, Vranckx K, López Rodríguez A, Chiers K, Haesebrouck F, et al. Efficacy of florfenicol injection in the treatment of Mycoplasma hyopneumoniae induced respiratory disease in pigs. Vet J. 2012;194:420–2.
Article
Google Scholar
Vranckx K, Maes D, Marchioro SB, Villarreal I, Chiers K, Pasmans F, et al. Vaccination reduces macrophage infiltration in bronchus-associated lymphoid tissue in pigs infected with a highly virulent Mycoplasma hyopneumoniae strain. BMC Vet Res. 2012;8:1–7.
Article
Google Scholar
Villarreal I, Maes D, Meyns T, Gebruers F, Calus D, Pasmans F, et al. Infection with a low virulent Mycoplasma hyopneumoniae isolate does not protect piglets against subsequent infection with a highly virulent M. hyopneumoniae isolate. Vaccine. 2009;27:1875–9.
Article
CAS
PubMed
Google Scholar
Vicca J, Maes D, Jonker L, De Kruif A, Haesebrouck F. Efficacy of in-feed medication with tylosin for the treatment and control of Mycoplasma hyopneumoniae infections. Vet Rec. 2005;156:606–10.
Article
CAS
PubMed
Google Scholar
Meyns T, Maes D, Dewulf J, Vicca J, Haesebrouck F, de Kruif A. Quantification of the spread of Mycoplasma hyopneumoniae in nursery pigs using transmission experiments. Prev Vet Med. 2004;66:265–75.
Article
PubMed
Google Scholar
Meyns T, Maes D, Calus D, Ribbens S, Dewulf J, Chiers K, et al. Interactions of highly and low virulent Mycoplasma hyopneumoniae isolates with the respiratory tract of pigs. Vet Microbiol. 2007;120:87–95.
Article
CAS
PubMed
Google Scholar
Baskerville A. Development of the early lesions in experimental enzootic pneumonia of pigs: an ultrastructural and histological study. Res Vet Sci. 1972;13:570–8.
CAS
PubMed
Google Scholar
Sarradell J, Andrada M, Ramirez AS, Fernández A, Gómez-Villamandos JC, Jover A, et al. A morphologic and Immunohistochemical study of the bronchus-associated lymphoid tissue of pigs naturally infected with Mycoplasma hyopneumoniae. Vet Pathol. 2003;40:395–404.
Article
CAS
PubMed
Google Scholar
Nathues H, Spergser J, Rosengarten R, Kreienbrock L, Grosse Beilage E. Value of the clinical examination in diagnosing enzootic pneumonia in fattening pigs. Vet J. 2012;193:443–7.
Article
PubMed
Google Scholar
Leon EA, Madec F, Taylor NM, Kobisch M. Seroepidemiology of Mycoplasma hyopneumoniae in pigs from farrow-to-finisch farm. Vet Microbiol. 2001;78:331–41.
Article
CAS
PubMed
Google Scholar
Thacker EL, Thacker BJ, Kuhn M, Hawkins PA, Waters WR. Evaluation of local and systemic immune responses induced by intramuscular injection of a Mycoplasma hyopneumoniae bacterin to pigs. Am J Vet Res. 2000;61:1384–9.
Article
CAS
PubMed
Google Scholar
Woolley LK, Fell SA, Gonsalves JR JR, BBA R, Collins D, Kuit TA, et al. Evaluation of recombinant Mycoplasma hyopneumoniae P97/P102 paralogs formulated with selected adjuvants as vaccines against mycoplasmal pneumonia in pigs. Vaccine. 2014;32:4333–41.
Article
CAS
PubMed
Google Scholar
Djordjevic SP, Eamens GJ, Romalis LF, Nicholls PJ, Taylor DJ, Chin J. Serum and mucosal antibody responses and protection in pigs vaccinated against Mycoplasma hyopneumoniae with vaccines containing a denatured membrane antigen pool and adjuvant. Aust Vet J. 1997;75:504–11.
Article
CAS
PubMed
Google Scholar
Thacker EL, Thacker BJ, Young TF, Halbur PG. Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae. Vaccine. 2000;18:1244–52.
Article
CAS
PubMed
Google Scholar
Thacker E, Strait EL, Ruebling K, Nilubol D, Erickson B, White R. Evaluation of organism number and the immune response to one dose Mycoplasma hyopneumoniae vaccines. In: Blaha T, Pahlitzsch C, editors. 18th IPVS Congress. Hamburg, Germany; 2000.
Yang J, Hooper WC, Phillips DJ, Talkington DF. Cytokines in Mycoplasma pneumoniae infection. Cytokine Growth Factor Rev. 2004;15:157–68.
Article
CAS
PubMed
Google Scholar
Van Reeth K, Van Gucht S, Pensaert M. In vivo studies on cytokine involvement during acute viral respiratory disease of swine: troublesome but rewarding. Vet Immunol Immunopathol. 2002;87:161–8.
Article
PubMed
Google Scholar
Ahn KK, Kwon D, Jung K, Ha Y, Seo MJ, Kim S-H, et al. Identification of interleukin-1, tumor necrosis factor-α, and interleukin-6 expression in lungs from pigs naturally infected with Mycoplasma hyopneumoniae by in situ hybridization. J Vet Med Sci. 2009;71:441–5.
Article
PubMed
Google Scholar
Asai T, Okadaa M, Onoa M, Irisawaa T, Morib Y, Yokomizob Y, et al. Increased levels of tumor necrosis factor and interleukin 1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma hyopneumoniae. Vet Immunol Immunopathol. 1993;38:253–60.
Article
CAS
PubMed
Google Scholar
Rodriguez F, Ramireza GA, Sarradell J, Andradaa M, Lorenzo H. Immunohistochemical Labelling of cytokines in lung lesions of pigs naturally infected with Mycoplasma hyopneumoniae. J Comp Pathol. 2004;130:306–12.
Article
CAS
PubMed
Google Scholar
Sibila M, Pieters M, Molitor T, Maes D, Haesebrouck F, Segalés J. Current perspectives on the diagnosis and epidemiology of Mycoplasma hyopneumoniae infection. Vet J. 2009;181:221–31.
Article
PubMed
Google Scholar
Steenhard NR, Jungersen G, Kokotovic B, Beshah E, Dawson HD, Urban JFJ, et al. Ascaris suum infection negatively affects the response to a Mycoplasma hyopneumoniae vaccination and subsequent challenge infection in pigs. Vaccine. 2009;27:5161–9.
Article
CAS
PubMed
Google Scholar
Stevenson GW. Bacterial pneumonia in swine. In: Done S, Thomson J, Varley M, editors. 15th IPVS congress. Birmingham: Nottingham University Press; 1998.
Google Scholar
Martinod S. Protection against Mycoplasma hyopneumoniae and Actinobacillus pleuropneumoniae infections using a mycoplasma inactivated vaccine Respisure under field conditions. In: Moneti G, Vignola G, editors. 14th IPVS congress. Bologna: Press point-Abbiategrasso, Bologna; 1996.
Google Scholar
Hodgins DC, Shewen PE, Dewey CE. Influence of age and maternal antibodies on antibody responses of neonatal piglets vaccinated against Mycoplasma hyopneumoniae. J Swine Health Prod. 2004;12:10–6.
Google Scholar