Center SA: Diseases of the gallbladder and biliary tree. Vet Clin North Am Small Anim Pract. 2009, 39 (3): 543-598. 10.1016/j.cvsm.2009.01.004.
Article
PubMed
Google Scholar
Watson PJ, Roulois AJ, Scase TJ, Irvine R, Herrtage ME: Prevalence of hepatic lesions at post-mortem examination in dogs and association with pancreatitis. J Small Anim Pract. 2010, 51 (11): 566-572. 10.1111/j.1748-5827.2010.00996.x.
Article
CAS
PubMed
Google Scholar
Poldervaart JH, Favier RP, Penning LC, van den Ingh TS, Rothuizen J: Primary hepatitis in dogs: a retrospective review (2002-2006). J Vet Intern Med. 2009, 23 (1): 72-80. 10.1111/j.1939-1676.2008.0215.x.
Article
CAS
PubMed
Google Scholar
Favier RP: Idiopathic hepatitis and cirrhosis in dogs. Vet Clin North Am Small Anim Pract. 2009, 39 (3): 481-488. 10.1016/j.cvsm.2009.01.002.
Article
PubMed
Google Scholar
Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S, Lipkin WI: Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci U S A. 2011, 108 (28): 11608-11613. 10.1073/pnas.1101794108.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bexfield NH, Watson PJ, Heaney J, Heeney JL, Tiley L: Canine hepacivirus is not associated with chronic liver disease in dogs. J Viral Hepat. 2014, 21 (3): 223-228. 10.1111/jvh.12150.
Article
PubMed Central
CAS
PubMed
Google Scholar
van der Laan LJ, de Ruiter PE, van Gils IM, Fieten H, Spee B, Pan Q, Rothuizen J, Penning LC: Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort. J Viral Hepat. 2014, 21 (12): 894-896. 10.1111/jvh.12268.
Article
CAS
PubMed
Google Scholar
Riehle KJ, Dan YY, Campbell JS, Fausto N: New concepts in liver regeneration. J Gastroenterol Hepatol. 2011, 26 (Suppl 1): 203-212. 10.1111/j.1440-1746.2010.06539.x.
Article
PubMed Central
PubMed
Google Scholar
Duncan AW, Dorrell C, Grompe M: Stem cells and liver regeneration. Gastroenterology. 2009, 137 (2): 466-481. 10.1053/j.gastro.2009.05.044.
Article
PubMed Central
PubMed
Google Scholar
Saxena R, Theise N: Canals of Hering: recent insights and current knowledge. Semin Liver Dis. 2004, 24: 43-48. 10.1055/s-2004-823100.
Article
PubMed
Google Scholar
Ijzer J, Schotanus BA, Vander Borght S, Roskams TA, Kisjes R, Penning LC, Rothuizen J, van den Ingh TS: Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: an immunohistochemical comparison between dog and man. Vet J. 2010, 184 (3): 308-314. 10.1016/j.tvjl.2009.02.016.
Article
CAS
PubMed
Google Scholar
Schotanus BA, van den Ingh TS, Penning LC, Rothuizen J, Roskams TA, Spee B: Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease. Liver Int. 2009, 29 (8): 1241-1252. 10.1111/j.1478-3231.2009.02024.x.
Article
PubMed
Google Scholar
Kruitwagen HS, Spee B, Viebahn CS, Venema HB, Penning LC, Grinwis GC, Favier RP, van den Ingh TS, Rothuizen J, Schotanus BA: The canine hepatic progenitor cell niche: molecular characterisation in health and disease. Vet J. 2014, 201 (3): 345-352. 10.1016/j.tvjl.2014.05.024.
Article
CAS
PubMed
Google Scholar
Ijzer J, Kisjes JR, Penning LC, Rothuizen J, van den Ingh TS: The progenitor cell compartment in the feline liver: an (immuno)histochemical investigation. Vet Pathol. 2009, 46 (4): 614-621. 10.1354/vp.07-VP-0097-I-FL.
Article
CAS
PubMed
Google Scholar
Kruitwagen HS, Spee B, Schotanus BA: Hepatic progenitor cells in canine and feline medicine: potential for regenerative strategies. BMC Vet Res. 2014, 10 (1): 137-10.1186/1746-6148-10-137.
Article
PubMed Central
PubMed
Google Scholar
Hu M, Kurobe M, Jeong YJ, Fuerer C, Ghole S, Nusse R, Sylvester KG: Wnt/beta-catenin signaling in murine hepatic transit amplifying progenitor cells. Gastroenterology. 2007, 133 (5): 1579-1591. 10.1053/j.gastro.2007.08.036.
Article
CAS
PubMed
Google Scholar
Itoh T, Kamiya Y, Okabe M, Tanaka M, Miyajima A: Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response. FEBS Lett. 2009, 583 (4): 777-781. 10.1016/j.febslet.2009.01.022.
Article
CAS
PubMed
Google Scholar
Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N: Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells. J Cell Biochem. 2009, 108 (1): 295-303. 10.1002/jcb.22254.
Article
CAS
PubMed
Google Scholar
Spee B, Carpino G, Schotanus BA, Katoonizadeh A, Vander Borght S, Gaudio E, Roskams T: Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut. 2010, 59 (2): 247-257. 10.1136/gut.2009.188367.
Article
PubMed
Google Scholar
Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS: Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech. 2011, 4 (3): 359-367. 10.1242/dmm.005793.
Article
PubMed Central
CAS
PubMed
Google Scholar
Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Seo SS, Spee B, Van Rooijen N, Sansom OJ, Iredale JP, Lowell S, Roskams T, Forbes SJ: Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med. 2012, 18 (4): 572-579. 10.1038/nm.2667.
Article
PubMed Central
CAS
PubMed
Google Scholar
Thompson MD, Monga SP: WNT/beta-catenin signaling in liver health and disease. Hepatology. 2007, 45 (5): 1298-1305. 10.1002/hep.21651.
Article
CAS
PubMed
Google Scholar
Flynn DM, Nijjar S, Hubscher SG, de Goyet JV, Kelly DA, Strain AJ, Crosby HA: The role of Notch receptor expression in bile duct development and disease. J Pathol. 2004, 204 (1): 55-64. 10.1002/path.1615.
Article
CAS
PubMed
Google Scholar
Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H: Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation. Gastroenterology. 2007, 133 (3): 937-950. 10.1053/j.gastro.2007.06.016.
Article
CAS
PubMed
Google Scholar
Gramantieri L, Giovannini C, Lanzi A, Chieco P, Ravaioli M, Venturi A, Grazi GL, Bolondi L: Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. Liver Int. 2007, 27 (7): 997-1007. 10.1111/j.1478-3231.2007.01544.x.
Article
CAS
PubMed
Google Scholar
Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP: Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology. 2008, 47 (5): 1667-1679. 10.1002/hep.22225.
Article
PubMed Central
CAS
PubMed
Google Scholar
Köhler C, Bell AW, Bowen WC, Monga SP, Fleig W, Michalopoulos GK: Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology. 2004, 39 (4): 1056-1065. 10.1002/hep.20156.
Article
PubMed Central
PubMed
Google Scholar
Roskams T: Different types of liver progenitor cells and their niches. J Hepatol. 2006, 45 (1): 1-4. 10.1016/j.jhep.2006.05.002.
Article
PubMed
Google Scholar
Apte U, Thompson MD, Cui S, Liu B, Cieply B, Monga SP: Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology. 2008, 47 (1): 288-295. 10.1002/hep.21973.
Article
CAS
PubMed
Google Scholar
Yang W, Yan HX, Chen L, Liu Q, He YQ, Yu LX, Zhang SH, Huang DD, Tang L, Kong XN, Chen C, Liu SQ, Wu MC, Wang HY: Wnt/beta-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Cancer Res. 2008, 68 (11): 4287-4295. 10.1158/0008-5472.CAN-07-6691.
Article
CAS
PubMed
Google Scholar
Jeliazkova P, Jörs S, Lee M, Zimber-Strobl U, Ferrer J, Schmid RM, Siveke JT, Geisler F: Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology. 2013, 57 (6): 2469-2479. 10.1002/hep.26254.
Article
CAS
PubMed
Google Scholar
Fiorotto R, Raizner A, Morell CM, Torsello B, Scirpo R, Fabris L, Spirli C, Strazzabosco M: Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. J Hepatol. 2013, 59 (1): 124-130. 10.1016/j.jhep.2013.02.025.
Article
PubMed Central
CAS
PubMed
Google Scholar
Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G, Brenner DA, Kisseleva T: Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology. 2010, 139: 987-998. 10.1053/j.gastro.2010.05.005.
Article
PubMed Central
CAS
PubMed
Google Scholar
Swiderska-Syn M, Suzuki A, Guy CD, Schwimmer JB, Abdelmalek MF, Lavine JE, Diehl AM: Hedgehog pathway and pediatric nonalcoholic fatty liver disease. Hepatology. 2013, 57 (5): 1814-1825. 10.1002/hep.26230.
Article
PubMed Central
CAS
PubMed
Google Scholar
Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Conde-Vancells J, Karaca GF, Diehl AM: Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology. 2009, 137: 1478-1488. 10.1053/j.gastro.2009.06.051.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kalluri R, Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 2009, 119 (6): 1420-148. 10.1172/JCI39104.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lim J, Thiery JP: Epithelial-mesenchymal transitions: insights from development. Development. 2012, 139 (19): 3471-3486. 10.1242/dev.071209.
Article
CAS
PubMed
Google Scholar
Lee JM, Dedhar S, Kalluri R, Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006, 172 (7): 973-981. 10.1083/jcb.200601018.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ: Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 2004, 18 (12): 1385-1390. 10.1101/gad.287404.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ober EA, Verkade H, Field HA, Stainier DY: Mesodermal Wnt2b signalling positively regulates liver specification. Nature. 2006, 442 (7103): 688-691. 10.1038/nature04888.
Article
CAS
PubMed
Google Scholar
Hay DC, Fletcher J, Payne C, Terrace JD, Gallagher RC, Snoeys J, Black JR, Wojtacha D, Samuel K, Hannoun Z, Pryde A, Filippi C, Currie IS, Forbes SJ, Ross JA, Newsome PN, Iredale JP: Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate. Proc Natl Acad Sci U S A. 2008, 105 (34): 12301-12306. 10.1073/pnas.0806522105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Decaens T, Godard C, de Reyniès A, Rickman DS, Tronche F, Couty JP, Perret C, Colnot S: Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Hepatology. 2008, 47 (1): 247-258. 10.1002/hep.21952.
Article
CAS
PubMed
Google Scholar
Ishii K, Yoshida Y, Akechi Y, Sakabe T, Nishio R, Ikeda R, Terabayashi K, Matsumi Y, Gonda K, Okamoto H, Takubo K, Tajima F, Tsuchiya H, Hoshikawa Y, Kurimasa A, Umezawa A, Shiota G: Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta. Hepatology. 2008, 48 (2): 597-606. 10.1002/hep.22362.
Article
CAS
PubMed
Google Scholar
Robrechts C, De Vos R, Van den Heuvel M, Van Cutsem E, Van Damme B, Desmet V, Roskams T: Primary liver tumour of intermediate (hepatocyte-bile duct cell) phenotype: a progenitor cell tumour?. Liver. 1998, 18 (4): 288-293. 10.1111/j.1600-0676.1998.tb00168.x.
Article
CAS
PubMed
Google Scholar
Libbrecht L, Desmet V, Van Damme B, Roskams T: The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol. 2000, 33 (1): 76-84. 10.1016/S0168-8278(00)80162-2.
Article
CAS
PubMed
Google Scholar
Alagille D, Estrada A, Hadchouel M, Gautier M, Odievre M, Dommerques JP: Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr. 1987, 110: 195-200. 10.1016/S0022-3476(87)80153-1.
Article
CAS
PubMed
Google Scholar
Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Traski BJ, Kuo WL, Cochran J, Costa T, Pierpont ME, Rand EB, Piccoli DA, Hood L, Spinner NB: Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nat Genet. 1997, 16: 243-251. 10.1038/ng0797-243.
Article
CAS
PubMed
Google Scholar
Tanimizu N, Miyajima A: Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci. 2004, 117: 3165-3174. 10.1242/jcs.01169.
Article
CAS
PubMed
Google Scholar
Nijjar SS, Crosby HA, Wallace L, Hubscher SG, Strain AJ: Notch receptor expression in adult human liver: a possible role in bile duct formation and hepatic neovascularization. Hepatology. 2001, 34: 1184-1192. 10.1053/jhep.2001.29399.
Article
CAS
PubMed
Google Scholar
Nijjar SS, Wallace L, Crosby HA, Hubscher SG, Strain AJ: Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol. 2002, 160: 1695-1703. 10.1016/S0002-9440(10)61116-9.
Article
PubMed Central
CAS
PubMed
Google Scholar
McCright B, Lozier J, Gridley T: A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development. 2002, 129: 1075-1082.
CAS
PubMed
Google Scholar
Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T: The role of notch signaling in the development of intrahepatic bile ducts. Gastroenterology. 2004, 127: 1775-1786. 10.1053/j.gastro.2004.09.004.
Article
CAS
PubMed
Google Scholar
Kuver R, Savard CE, Lee SK, Haigh WG, Lee SP: Murine gallbladder epithelial cells can differentiate into hepatocyte-like cells in vitro. Am J Physiol Gastrointest Liver Physiol. 2007, 293: G944-G955. 10.1152/ajpgi.00263.2006.
Article
CAS
PubMed
Google Scholar
Hayward P, Kalmar T, Arias AM: Wnt/Notch signalling and information processing during development. Development. 2008, 135: 411-424. 10.1242/dev.000505.
Article
CAS
PubMed
Google Scholar
Van den Ingh TSGAM, Van Winkle T, Cullen JM, Charles JA, Desmet VJ: Morphological classification of parenchymal disorders of the canine and feline liver: 2. Hepatocellular death, hepatitis and cirrhosis. WSAVA Standards for Clinical and Histological Diagnosis of Canine and Feline Liver Disease. Edited by: Rothuizen J, Bunch SE, Charles JA. 2006, Saunders-Elsevier, Edinburgh, 85-102. 10.1016/B978-0-7020-2791-8.50011-3.
Chapter
Google Scholar
van Steenbeek FG, Van den Bossche L, Grinwis GC, Kummeling A, van Gils IH, Koeramp MJ, van Leenen D, Holstege FC, Penning LC, Rothuizen J, Leegwater PA, Spee B: Aberrant gene expression I dog with portosystemic shunts. PLoS One. 2013, 8: e57662-10.1371/journal.pone.0057662.
Article
PubMed Central
CAS
PubMed
Google Scholar