6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells
The antimetabolite 6-thioguanine (6-TG) has been used to treat both human and canine lymphoid malignancies. 6-TG has been shown to be epigenetically active as a demethylating agent in a human lymphoma cell lin...