Potential for epidemic take-off from the primary outbreak farm via livestock movements
© Tildesley et al; licensee BioMed Central Ltd. 2011
Received: 3 December 2010
Accepted: 24 November 2011
Published: 24 November 2011
We consider the potential for infection to spread in a farm population from the primary outbreak farm via livestock movements prior to disease detection. We analyse how this depends on the time of the year infection occurs, the species transmitting, the length of infectious period on the primary outbreak farm, location of the primary outbreak, and whether a livestock market becomes involved. We consider short infectious periods of 1 week, 2 weeks and 4 weeks, characteristic of acute contagious livestock diseases. The analysis is based on farms in Scotland from 1 January 2003 to 31 July 2007.
The proportion of primary outbreaks from which an acute contagious disease would spread via movement of livestock is generally low, but exhibits distinct annual cyclicity with peaks in May and August. The distance that livestock are moved varies similarly: at the time of the year when the potential for spread via movements is highest, the geographical spread via movements is largest. The seasonal patterns for cattle differ from those for sheep whilst there is no obvious seasonality for pigs. When spread via movements does occur, there is a high risk of infection reaching a livestock market; infection of markets can amplify disease spread. The proportion of primary outbreaks that would spread infection via livestock movements varies significantly between geographical regions.
In this paper we introduce a set-up for analysis of movement data that allows for a generalized assessment of the risk associated with infection spreading from a primary outbreak farm via livestock movements, applying this to Scotland, we assess how this risk depends upon the time of the year, species transmitting, location of the farm and other factors.
The likelihood of epidemic take-off (spread from the primary outbreak farm to any other livestock holding) of an infectious disease introduced into a farm population is dependent upon a number of factors. Crucial to that are the pathways and chances for the infection to be transmitted from the primary outbreak to the rest of the population. Different types of contact between farms may result in transmission of infection [1–5]. However the movement of livestock has been observed to be the major route of spread of epidemics between farms during the period before the first farm is reported with disease (index case) - the "pre-detection" period. Examples include the two largest recent epidemics of contagious livestock diseases in the European Union - the outbreak of classical swine fever (CSF) in 1997-1998 (involving the Netherlands, Spain, Italy, Belgium and Germany) and the outbreak of foot and mouth disease (FMD) in 2001 (involving the UK, the Netherlands, France and the Republic of Ireland) [6–8]. Also, throughout the CSF outbreak the rate of between-herd transmission of infection via movements of pigs was much higher than that via any other route .
Lower and upper limits of the epidemic size in a farm network can be projected by calculating the numbers of farms in the giant strongly- and weakly-connected components, respectively, of the network. Using these measures, it has been shown that the possible final size of an epidemic in British livestock networks depends on the time of the year when the primary outbreak becomes infected for the cattle, sheep and mixed farm networks [9, 10]. The epidemic size is also dependent upon the location of the primary outbreak [11, 12]. In addition, a review of FMD outbreaks in all non-endemic areas of the world during 1992-2003 suggested that for this (characteristic acute contagious) disease the movement of infectious animals through a livestock market/auction at the start of an epidemic contributes the most to the epidemic's final size being exceptionally large (>2,000 infected premises) . Therefore the early stages of an epidemic have a profound effect on the final number of farms infected and therefore its ultimate impact .
We introduce a framework to analyze livestock movements to evaluate an upper bound on the probability of spread of infection in a farm population from a primary outbreak farm via movements. Scottish farm networks are used as a model; the networks are evaluated from 1 January 2003 to 31 July 2007. A total of 27,400 farms appeared in the Scottish livestock networks from 1 January 2003 to 31 July 2007. Of these, 22,418 traded sheep, 15,634 traded cattle and 2,270 traded pigs, to/from other farms on at least one occasion. We consider both direct movements from the primary outbreak farm to other farms and movements that involve livestock markets. We analyse the dependency of each of these on the time of the year that infection occurs, the length of the infectious period (defined below) on the primary outbreak farm, and the species of livestock transmitting the disease.
In this paper, we focus on acute contagious livestock diseases. For these diseases, the length of time between the introduction of infection on the primary outbreak farm and the manifestation of clinical signs of disease in animals (disease detection) may vary. The primary outbreak farm remains "infectious" throughout the pre-detection period. The length of this period is dependent upon the virulence of the pathogen strain and the species infected. For example, the appearance of clinical signs of FMD is variable between species, with cattle and pigs typically showing signs far earlier than sheep. A 1 or 2 week farm-infectious period may be realistic when the primary outbreak species are cattle or pigs, whilst a 2 or 4 week period may be realistic for an outbreak starting in sheep. Moreover, for cattle, this would also depend on the strain of FMD virus. In the UK 2001 FMD outbreak, short pre-detection periods of < 10 days were generally observed. However in 1967 and 2007, pre-detection periods of up to 3 weeks were observed for a different strain of FMD virus. For CSF, an acute form of disease often manifests in 2-3 days, but, dependent on the strain, may take up to 2 weeks; a less virulent strain causing a sub-acute form of the disease may take even longer to detect. We therefore consider infectious periods on the primary outbreak farm of 1 week, 2 weeks and 4 weeks.
We then consider the number of farms in the first generation of an epidemic spreading through the livestock movement network. We also evaluate how the potential for spread of infection via movements varies between the regions of Scotland.
Potential for spread of infection from the primary outbreak farm via livestock movements
The seasonal patterns in the proportion of farms that can spread infection via livestock movements differed between species of livestock. The movement of sheep exhibited a single strong annual peak in mid-August (Figure 1B). At this time of the year, the infection would spread to at least 1 other farm via sheep movements from >20% of the primary outbreaks infectious for 4 weeks, whilst this value dropped to < 8% at all other times of the year. For cattle, the annual maximum of the proportion of farms with off-movements during a 4-week period was lower than for sheep. Also in contrast to sheep, this proportion for cattle peaked twice per year - in early May and in mid-August (Figure 1B). The peak in August tended to be slightly higher than that in May, with some year-to-year variation. During a 4-week infectious period commencing in mid-August, between 12% and 16% of primary outbreaks would have resulted in spread via cattle movement. The percentage of farms with off-movements of pigs was found to be the lowest of the three species, with spread occurring from < 0.5% of primary outbreaks at any given time of the year during a 4-week infectious period (Figure 1B). There was no obvious seasonality in pig movement.
Potential for infection to reach a livestock market
Numbers of farms in the first-generation of an epidemic
Proportion of primary outbreak farms spreading infection to a given number of farms during the first generation of an epidemic (averaged over the period from 1 January 2003 to 31 July 2007) for a disease transmitted by any livestock depending on the length of the infectious period on the primary outbreak farm.
No. of farms in first generation
Proportion of primary outbreak farms causing spread for a given infectious period
Distance of movement
The mean distances travelled by cattle and sheep during the epidemic's first generation (with a 2-week infectious period) show cyclic annual behaviour similar to that of the potential for infection to spread via movements (Figure 6A; cf. Figure 1B). Dependent upon time of year, the mean distance of movement of cattle or sheep varies from 30 km to 120 km. Cattle travel furthest on average in late April/early May and in late August, with mean distances of 80-90 km and 90-100 km respectively (Figure 6A). Mean distances of sheep movement are ≤ 80 km for the first half of the year and peak at 100-120 km in mid-August (Figure 6A). The maximum distance of movement during the epidemic's first generation (with a 2-week infectious period), when averaged over all potential primary outbreak farms, closely mirrors the mean distance moved, with peaks of 100-120 km in April/May and 120-140 km in August for cattle, and 130-140 km in August for sheep (Figure 6B). However the maximum distance cattle and sheep may be moved during the epidemic's first generation is between 200 km and 650 km; there is no obvious seasonality in the maximum distance for cattle; for sheep it tends to peak between August and November. This indicates that, whilst average distances of movement are much lower, there is the potential for infection to spread across very significant distances prior to the detection of the outbreak.
No apparent annual cyclic behaviour is observed for distance of movement of pigs. When the infectious period on the primary outbreak farm is 2 weeks, the mean distance of movement during the first generation of an epidemic of a pig disease varies between 30 km and 80 km, whilst the maximum distance averaged over the primary outbreaks is slightly greater than this, at around 87 km. The maximum distance of pig movement varies between 100 km and 400 km. Whilst these maximum distances are significantly lower than in the cattle and sheep networks, there remains the potential for pig infection to be transmitted from the primary outbreak farm to a region several hundred kilometres away.
For a disease transmitted by cattle, if we assume that once a market is infected all movements from the market spread disease, the mean number of farms infected within 4 weeks of the primary outbreak farm becoming infectious is found to peak at 700-800 in late April/early May and at 600-700 in August (Figure 7A). However, if we assume that only movements from the infected farms transmit disease, the number of farms infected after 4 weeks is significantly lower, at around 400-550 farms in late April/early May and 400-500 farms in August (Figure 7A). For a disease transmitted by sheep, the peak in mid-August is also somewhat lower, at around 750-1100 farms when only movements from infected farms spread disease, compared with 1200-1400 farms when all movements from infected markets are infectious (Figure 7B). Perhaps more significantly, if we assume that only the livestock from infected farms spread disease, then for outbreaks commencing between January and July of each year, on average, fewer than 50 farms become infected, compared with up to 300 farms if all movements from infected markets are infectious (Figure 7B). These results imply that transmission of infection among animals at the market can amplify the spread of disease in the farm network. If the transmission at markets is likely to occur, the results in Figure 2, in which the proportion of primary outbreak farms spreading infection to a market is shown, provide a better indication of the likelihood of a large epidemic occurring. For a less contagious disease, for which the transmission at markets is unlikely, a better indication is the proportion of primary outbreaks spreading infection to any other farm, shown in Figure 1.
The primary aim of this paper is to assess the potential for epidemic to take off from a primary outbreak farm via livestock movements prior to disease detection. This potential is measured as the proportion of primary outbreak farms moving livestock to other farms whilst infectious. This analytical set-up is applied to Scottish livestock networks. The results demonstrate that the potential for epidemic take-off of a short-lived infection via livestock movements in this farm population is generally low throughout the year, averaging, for a disease transmitted by all livestock species, 0.03 when the animals on the primary outbreak remain infectious for 1 week, 0.09 for 2 weeks, and 0.17 for 4 weeks (Figure 1A).
Annual cyclicity of livestock movements is similar across regions of Scotland, but the maximum potential for infection spread at peak seasons and the average potential throughout the year differ (Figure 5). The latter was highest for primary outbreaks occurring on Orkney (housing 3.6% of the Scottish farms trading livestock during the study period), and the Inner Hebrides (housing 1.9% of the farms), while it was the lowest for primary outbreaks on Shetland, which alone housed 4.4% of the farms. Therefore, a high potential for spread of infection via movements can be seen for disease introductions into the regions with modest farm populations. Here we considered only the potential for spread via livestock movements; other modes of between-farm transmission of infection may depend on the numbers or densities of farms in the region [14, 15].
The potential for any spread from the primary outbreak via movements, and the potential for infectious animals to be moved to a livestock market, appear to depend non-linearly on the length of infectious period on the farm (Figures 1 and 2). This may be because, under the standstill requirements, in many cases the movement of livestock off the farm is restricted for some days following an on-movement.
For a disease transmitted only by sheep, the proportion of primary outbreaks resulting in infection spread via movements peaks at a single point of the year - in mid-August (Figure 1B). For a cattle-only disease, this potential overall is lower, but also peaks in mid-August (with a secondary peak in early May; Figure 1B). Sheep movements in the other parts of Great Britain also peak in August . However, when considered for the entirety of Great Britain between November 2001 and October 2003, cattle movements were observed to peak in April and October . The seasonal adjustment of the surveillance effort to account for the peaks in cattle movements in Britain has been previously suggested . A vigorous surveillance for contagious livestock diseases in Scotland at the peak of cattle and sheep movements in August may provide greatest benefit in terms of precluding significant pre-detection spread of infection between farms via livestock movements.
In August 2003, an outbreak of FMD occurred in Surrey, England. The farms in Scotland were not affected, but the restrictions imposed on the livestock movements due to the outbreak led to sizable consequences for the economy and for animal welfare [19, 20]. According to our results, if the virus had been introduced to Scotland prior to detection of the outbreak, the likelihood of pre-detection spread via livestock movement would have been at its highest. This episode highlighted the importance of disease surveillance at this time of the year, but also the dilemma between the needs of disease control and the necessity for sufficient animal movement to take place to sustain the functioning of the industry.
The magnitude of the proportion of primary outbreak farms that can move infectious animals to a livestock market and its annual cyclicity are close to that for any spread from the primary outbreak via movements (Figure 2 versus Figure 1A). This is because 86% of sheep movements, 80% of beef and 42% of dairy cattle movements between Scottish farms during the study period occurred via markets, accounting for 79% of all the livestock movements. Therefore, even though the potential for infection to spread via movements from the primary outbreak in Scotland is generally low, if the spread does occur, it is likely via a market. A review of FMD outbreaks in non-endemic areas of the world between 1992 and 2003 showed that the movement of infectious animals through a market/auction at the beginning of an epidemic contributes to a large final epidemic size . A decrease in the number of cattle movements between farms and markets over the entirety of Great Britain was reported for 2003 and 2004, compared to 2002 . In Scotland on its own, the fraction of cattle movements via markets remained consistently high, from 78% to 82%, and the fraction of sheep movements varied from 83.5% to 88% each year from 2003 to 2007.
If we assume that once livestock is brought from the primary outbreak to the market, all subsequent movements from the market will transmit infection, in Figure 7 we see that there is the potential for disease to spread to several hundred farms within 4 weeks of the primary outbreak becoming infectious (if this remained infectious for 2 weeks). These results agree with a simulation study which showed that only small-size FMD outbreaks in Great Britain are possible without the amplification of transmission by an infected market . Jointly, the results imply that in order to prevent large-scale disease outbreaks occurring in Britain, control emphasis should be placed upon the risk of spread from the primary outbreak to a market via movements of cattle or sheep.
In contrast, for a pig disease, the proportion of farms from which infection can spread via movements is very low throughout the year (< 0.005), with no obvious seasonal peaks, and no involvement of the markets. Therefore, a large-scale epidemic of a pig disease due to pre-detection spread via movements appears to be unlikely. The Scottish pig industry is a fattening industry; therefore the movements are normally confined within the breeder-fattening progeny pyramids, and happen only at certain points of the production cycle. This pyramidal structure of movements may account for the significant differences observed in the risks of epidemic take-off when compared with the cattle and sheep networks. However, our results need to be considered against the likely accuracy of data on pig movements. The movements within the pyramids may be under-reported owing to both source and destination holdings belonging to the same business. Our conclusions do agree however with those from a simulation study based on pig movements in Sweden, where from no to very limited spread was observed for an epidemic seeded to a fattening or a farrow-to-finish pig herd . Also, in Belgian pig industries the farrow-to-finish herds were reported to have lower numbers of (farm-to-farm) movements compared to the other types of farms .
Another aspect of the risk of pre-detection spread of disease in a farm population via movements is the number of farms in the first generation of epidemic. This is defined here as the number of farms receiving livestock from the primary outbreak while it is infectious, and therefore measures the upper limit of the possible first generation, given no disease transmission at markets. In this analysis, the majority of primary outbreaks produce a first generation of 0 and a significant fraction produce a first generation of 1 farm. However, a small fraction of introductions can result in larger outbreaks. In rare cases up to 200 farms can be infected in the first generation (for an infectious period of 4 weeks). We speculate that such large first generations were observed for primary outbreak farms that were either dealing, or both farming and dealing livestock. Dealers have played a part in livestock movements in Scotland for decades . A comprehensive identification of dealerships would allow efficient targeting of control to curtail the risk of pre-detection spread of epidemics via livestock movements. Also, seasonal sheep shows in Scotland can be held on farms (rather than on the registered show-grounds omitted from this analysis), although it is probably unlikely that the sheep would be returning to such large number of farms.
Whilst we consider scenarios of diseases transmitted by cattle, sheep or pigs separately, we do not analyse the risk of an epidemic occurring based upon the type of primary outbreak farm (e.g. breeder farm versus a feedlot for cattle). Number of contacts a pig holding makes was shown to depend on the holding type in Swedish  and Belgian  industries. It may be that in Scotland those livestock farms with greater number of contacts are breeding farms with high sanitary levels and biosecurity; this would decrease the risk of epidemic spread compared to our results. Coupling the movement records investigated in this analysis with the results of British agricultural censuses would allow for an analysis of the risk owing to farm type, and this is an aim for future research.
Our analysis is based on datasets from the systems that collated records of livestock movements (SAMS and CTS). A potential limitation is that, although the animal keepers (farmers, markets) were legally required to report the movements, it is possible that an unknown fraction of actual movements was not reported [1, 24, 25]. In addition, only around 90% of records of single movements of individual cattle from the CTS database were usable. Hence we may slightly under-quantify the numbers of livestock movements and the numbers of farms to which the animals were moved, and the upper bound of the risk of infection spread may be slightly higher than that suggested by our results.
The mean Euclidian distances cattle can travel during the first generation of an epidemic with a 2-week infectious period in Scotland at peak movement seasons are from 80 km to 100 km (Figure 6A). These are slightly larger compared to the average for Great Britain in 2001-2003 , and in 2004 , and sizably larger compared to median distance of cattle movements in the Netherlands in 2002-2003 , or mean or median distances of movements of cattle and sheep in New Zealand . The mean distance of pig movements during a 2-week epidemic's first generation in Scotland can be between 30 km and 80 km. These are similar to the distances pigs are moved in Sweden , but are larger than the 19 km median distance of pig movements between farms in Belgium . Hence there may be an opportunity for a larger geographical spread of a livestock infection prior to the detection of the outbreak in Scotland, compared to the livestock industries in continental Europe.
Further comparison of our observations to other parts of Europe highlights the similarities and differences in the rates and seasonal patterns of livestock movements between European territories. The double annual peak in cattle movement prior to and after the summer observed here for Scotland is also present in Sweden and in Italy [28, 29]. However in Italy, in contrast to Scotland, cattle movements to markets increase from July to their annual maximum in October, and this post-summer peak is largely composed of cattle imports reared in other countries . The median of 2 cattle per daily movement between two Scottish farms is close to that in Denmark, where it is 1 to 3 ; occasional movements of large numbers of cattle between farms also occur in both countries. The mean of 3 cattle per daily movement between two farms in Scotland is close to the 2.2 to 4.8 cattle per batch moving between farms in Italy . The size of Scottish pig industry is small (total headage < 500,000 in each year 2003-2007 ) compared to some other European territories, e.g. Scandinavian, German or Dutch pig industries. However, we find that the uniform pattern of pig movements off Scottish farms throughout the year is similar to those reported in Denmark  and Sweden . On the other hand, the median of 106 pigs per daily movement between two Scottish farms is fewer than that between two fattening holdings in Denmark, where it is 130-570 animals . The patterns of livestock movements in individual regions of Europe are underlined by the conditions (climate, availability of pastures, etc) and traditions of livestock farming and trading. Nonetheless, the differences are likely to have implications for implementation of any common approaches to govern livestock movements to prevent or manage future epidemics. How these differences affect the potential for pre-detection spread of acute contagious livestock diseases via livestock movements can be quantified using analyses similar to those presented in this paper.
We introduce a framework for analysis of livestock movement data to assess the potential for onward transmission of an acute contagious livestock disease from the primary outbreak farm via animal movements. It is applied to the Scottish farm networks, and the risk of epidemic take-off is assessed in this country-wide farm population in the absence of epidemic-associated restrictions on livestock movements. With an exotic disease in mind, this is the assessment of the potential for pre-detection spread of infection via movements. This complements information provided by methods for projecting the final epidemic size from the features of the farm network  or from the transmission potential of infection , which are only relevant once the epidemic has taken off.
Period of the study and livestock movement regulations
We aim to analyse livestock movements in the absence of epidemic-associated restrictions. This is analogous to considering the pre-detection period of an epidemic. The livestock movement restrictions associated with the FMD outbreak in the UK in 2001 were lifted in late 2002. The outbreak of FMD in Surrey in August 2007 led to restrictions of movements in Scotland until 31 December 2007. We therefore consider the period between 1 January 2003 and 31 July 2007. During this period, livestock movements on individual Scottish farms were subject to routine restrictions, known as "standstill". Standstill is a legally required period following a movement of livestock onto a farm during which no livestock may be moved from that farm to other farms (but livestock can be moved to slaughter). The legally required standstill period was 13 days following an on-movement of sheep, cattle or goats, and 20 days following an on-movement of pigs. However certain categories of movements were exempt from standstill, for example on holdings operating quarantine facilities.
Livestock movement data and movement definition
The Scottish Animal Movement System (SAMS) is operated by Scottish Government. SAMS collates records of movements of batches of sheep, pigs and goats in Scotland. The records from 1 January 2003 to 31 July 2007 were extracted and processed using the Python programming language, and then in SAS® 9.1.3 software for Windows (SAS Institute Inc., Cary, NC, USA). The vast majority of the records were found to be logical and usable . A batch of sheep, pigs or goats recorded to be moved from one Scottish holding to another on the same date was taken as a single movement. Multiple trucks could be used to transport a single batch of animals. The number of animals in each batch was available from the SAMS.
The Cattle Tracing System (CTS) of the British Cattle Movement Service is operated by the Department for the Environment, Food and Rural Affairs (DEFRA). The CTS collates records of single off-holding and on-holding movements of individual cattle in Great Britain. The records for Scotland from 1 January 2003 to 31 July 2007 were extracted. The records of movements of individual cattle for whom a logical movement history (sensu lato Mitchell et al. ) could be derived were separated for analysis. This resulted in the use of approximately 90% of the underlying individual-movement records. The data were summarized in a table where all cattle moved from one Scottish holding to another on the same date were considered as a single movement. The number of cattle per movement was counted. This table was assembled using the Python programming language; further data processing was done in SAS® 9.1.3 software for Windows.
The list of livestock markets, show-grounds, abattoirs and other industry units registered in Scotland was collated with help from the Livestock Traceability Policy Branch, Animal Health and Welfare Division, Scottish Government, and from the Animal Health agency in Scotland. This list was used to cross-check the types of holdings in the livestock movement records to insure that only movements between Scottish farms, directly or via Scottish livestock markets, were being analysed as such. Common-land premises were considered as farms. The records of the farm-(market)-farm movements were separated for analysis from both the SAMS and the table derived from the CTS. Other types of movements were excluded: from farms to abattoirs, between farms and registered show-grounds or insemination centres, movements from farms to/from non-farm holdings such as calf collection centres, between non-farm holdings, etc.
There may be a risk, theoretically, of infected livestock moving via a market to slaughter passing infection on to other livestock moving through that same market to farms. However, on Scottish markets the sheep and cattle designated for slaughter are normally sold on different days of the week from the sheep and cattle designated for breeding or further rearing (Roy Paterson, Scottish Government, and Andrew Wright, Institute of Auctioneers and Appraisers for Scotland, personal communication with Mike Lamont, Scottish Government). If these two groups of animals have to stay overnight on the same market, they are normally kept on different fields . Effort is made to transfer the livestock to abattoirs as quickly as possible to prevent the animals losing condition . Therefore, the risk of infection transmission from livestock sold via a market to slaughter to those sold through that market to farms is not considered in this analysis.
All Scottish farms (each defined by its unique holding-identifier) recorded (as per the movement data specified above) to trade sheep, cattle, pigs or goats to/from other Scottish farms at least once during the study period 1 January 2003 to 31 July 2007 were considered in this analysis. No further selection of the farms was done.
The source of infection or its latent period is not considered in this analysis. The length of infectious period on the primary outbreak farm (the period for which its livestock remain infectious) is taken to be 1 week, 2 weeks or 4 weeks. A disease which can be transmitted by a single species (sheep, cattle or pigs), or by all livestock (sheep, cattle, pigs and goats) is considered. A scenario is defined by the length of infectious period on the primary outbreak farm and the species transmitting. The proportions of primary outbreak farms moving animals to any other farm or to a livestock market are calculated for every scenario for every seeding date.
The number of farms in the epidemic's first generation depending on the length of infectious period on the primary outbreak is calculated for an infection transmitted by all livestock species. The first generation is defined as those farms receiving livestock from the infectious primary outbreak farm. The seasonality in the size of the first generation is evaluated for the primary outbreak farm remaining infectious for 4 weeks.
The regional variation over Scotland in the proportion of primary outbreaks resulting in infection spread via livestock movements is evaluated for the scenario of a disease transmitted by all livestock species with a 4-week infectious period.
The mean and maximum Euclidian distances the livestock are moved during the epidemic's first generation are calculated for cattle, sheep and pigs, considering a disease where the primary outbreak farm is infectious for 2 weeks.
In order to investigate the potential risk of markets amplifying infection transmission during an epidemic in cattle or sheep, we estimate the number of farms infected within 4 weeks of the primary outbreak farm becoming infectious. Here we assume that the livestock brought from the primary outbreak to the market transmit infection to the rest of animals at the market, and all subsequent movements from the market result in transmission. Epidemics again are seeded every 5 days from 1 January 2003 to 31 July 2007 for a disease where the primary outbreak farm is infectious for 2 weeks, and the market remains infectious for 2 weeks after receiving animals from the primary outbreak. The results are compared against the assumption that infection is transmitted only by the livestock that are moved from the infected farms.
Regions of Scotland
Each of the four Scottish island archipelagos has a distinct pattern of livestock movements throughout the year; within the Scottish mainland movements are also non-uniform [24, 32]. One way to consider regionalization of livestock movement controls within Scotland is by the five divisional offices of Animal Health (acting as British governmental veterinary services). However, one of the offices oversees both the Orkney and Shetland archipelagos, and another incorporates the Western Isles. Moreover, the geographical coverage of each office does not exactly correspond to large-scale administrative borders. We therefore allocate the counties of the Scottish mainland into five regions, roughly corresponding to the mainland parts of the five offices, but consider each of the four Scottish island archipelagos on its own (Figure 4). We analyze livestock movements in each of these nine regions of Scotland.
Acknowledgements and funding
We would like to thank Gary Ferguson, Kevin Duffy and other personnel of Scottish Government for work on the SAMS extracts; the RADAR team of DEFRA for assistance with the CTS extracts, and the IBM team for work on the extracts. We thank Derek Wilson and Roy Paterson of Scottish Government, and Paul Honeyman of Animal Health for information on livestock industries in Scotland; and Iain McKendrick of BioSS for information on the offices of Animal Health in Scotland. We are grateful to Nicholas Savill of University of Edinburgh for assistance with data processing, and to Martin Miller for his useful comments on the manuscript. We appreciate the helpful communication of Andrew Wright of Institute of Auctioneers and Appraisers for Scotland with Mike Lamont. We appreciate the support of Nick Ambrose and Mike Lamont of Scottish Government.
This work was undertaken through the Centre of Excellence in Epidemiology, Population Health and Infectious Disease Control (EPIC) supported by Scottish Government. MJT is supported by the Wellcome Trust, and the Research and Policy for Infectious Disease Dynamics (RAPIDD) Program, Directorate of Science and Technology, U.S. Department of Homeland Security, Chemical/Biological Division and the Foreign Animal Disease Modeling program of the Science and Technology Directorate, Department of Homeland Security (grant ST-108-000017).
- Vernon MC, Webb CR, Heath MF: Postal survey of contacts between cattle farms on the Isle of Lewis. Vet Rec. 2010, 166 (2): 37-40. 10.1136/vr.c69.PubMedView ArticleGoogle Scholar
- Sanson RL, Struthers G, King P, Weston JF, Morris RS: The potential extent of transmission of foot-and-mouth disease: a study of the movement of animals and materials in Southland, New Zealand. N Z Vet J. 1993, 41 (1): 21-28. 10.1080/00480169.1993.35730.PubMedView ArticleGoogle Scholar
- Brennan ML, Kemp R, Christley RM: Direct and indirect contacts between cattle farms in north-west England. Prev Vet Med. 2008, 84 (3-4): 242-260. 10.1016/j.prevetmed.2007.12.009.PubMedView ArticleGoogle Scholar
- Ribbens S, Dewulf J, Koenen F, Mintiens K, de Kruif A, Maes D: Type and frequency of contacts between Belgian pig herds. Prev Vet Med. 2009, 88 (1): 57-66. 10.1016/j.prevetmed.2008.08.002.PubMedView ArticleGoogle Scholar
- Stegeman JA, Elbers ARW, Bouma A, de Jong MCM: Rate of inter-herd transmission of classical swine fever virus by different types of contact during the 1997-8 epidemic in The Netherlands. Epidemiol Infect. 2002, 128 (2): 285-291.PubMed CentralPubMedGoogle Scholar
- Ortiz-Pelaez A, Pfeiffer DU, Soares-Magalhaes RJ, Guitian FJ: Use of social network analysis to characterize the pattern of animal movements in the initial phases of the 2001 foot and mouth disease (FMD) epidemic in the UK. Prev Vet Med. 2006, 76 (1-2): 40-55. 10.1016/j.prevetmed.2006.04.007.PubMedView ArticleGoogle Scholar
- Gibbens JC, Sharpe CE, Wilesmith JW, Mansley LM, Michalopoulou E, Ryan JB, Hudson M: Descriptive epidemiology of the 2001 foot-and-mouth disease epidemic in Great Britain: the first five months. Vet Rec. 2001, 149 (24): 729-743.PubMedGoogle Scholar
- Elbers ARW, Stegeman A, Moser H, Ekker HM, Smak JA, Pluimers FH: The classical swine fever epidemic 1997-1998 in the Netherlands: descriptive epidemiology. Prev Vet Med. 1999, 42 (3-4): 157-184. 10.1016/S0167-5877(99)00074-4.View ArticleGoogle Scholar
- Robinson SE, Everett MG, Christley RM: Recent network evolution increases the potential for large epidemics in the British cattle population. J R Soc Interface. 2007, 4 (15): 669-674. 10.1098/rsif.2007.0214.PubMed CentralPubMedView ArticleGoogle Scholar
- Kao RR, Danon L, Green DM, Kiss IZ: Demographic structure and pathogen dynamics on the network of livestock movements in Great Britain. Proc R Soc B. 2006, 273 (1597): 1999-2007. 10.1098/rspb.2006.3505.PubMed CentralPubMedView ArticleGoogle Scholar
- Tildesley MJ, Keeling MJ: Is R(0) a good predictor of final epidemic size: foot-and-mouth disease in the UK. Journal of theoretical biology. 2009, 258 (4): 623-629. 10.1016/j.jtbi.2009.02.019.PubMed CentralPubMedView ArticleGoogle Scholar
- Green DM, Kiss IZ, Kao RR: Modelling the initial spread of foot-and-mouth disease through animal movements. Proc R Soc B. 2006, 273 (1602): 2729-2735. 10.1098/rspb.2006.3648.PubMed CentralPubMedView ArticleGoogle Scholar
- McLaws M, Ribble C: Description of recent foot and mouth disease outbreaks in nonendemic areas: Exploring the relationship between early detection and epidemic size. Can Vet J. 2007, 48 (10): 1051-1062.PubMed CentralPubMedGoogle Scholar
- Boender GJ, Nodelijk G, Hagenaars TJ, Elbers ARW, de Jong MCM: Local spread of classical swine fever upon virus introduction into The Netherlands: Mapping of areas at high risk. BMC Vet Res. 2008, 4:Google Scholar
- Savill NJ, Shaw DJ, Deardon R, Tildesley MJ, Keeling MJ, Woolhouse ME, Brooks SP, Grenfell BT: Topographic determinants of foot and mouth disease transmission in the UK 2001 epidemic. BMC Vet Res. 2006, 2: 3-10.1186/1746-6148-2-3.PubMed CentralPubMedView ArticleGoogle Scholar
- Kiss IZ, Green DM, Kao RR: The network of sheep movements within Great Britain: Network properties and their implications for infectious disease spread. J R Soc Interface. 2006, 3 (10): 669-677. 10.1098/rsif.2006.0129.PubMed CentralPubMedView ArticleGoogle Scholar
- Mitchell A, Bourn D, Mawdsley J, Wint W, Clifton-Hadley R, Gilbert M: Characteristics of cattle movements in Britain - an analysis of records from the Cattle Tracing System. Anim Sci. 2005, 80: 265-273.View ArticleGoogle Scholar
- Robinson SE, Christley RM: Identifying temporal variation in reported births, deaths and movements of cattle in Britain. BMC Vet Res. 2006, 2: 11-10.1186/1746-6148-2-11.PubMed CentralPubMedView ArticleGoogle Scholar
- Scudamore J, Ross J: A review of the Scottish response to the recent foot and mouth disease outbreak and identification of lessons for the future, particularly in terms of reducing the risk to Scotland and the associated economic disruption. 2008, ISBN 9780755958092, [http://www.scotland.gov.uk/Publications/2008/06/23130049/0]Google Scholar
- Volkova VV, Bessell PR, Woolhouse ME, Savill NJ: The evaluation of risks of FMD in Scotland to assist with decision-making during the UK 2007 FMD outbreak. Vet Rec. 2011, 169 (124):Google Scholar
- Robinson SE, Christley RM: Exploring the role of auction markets in cattle movements within Great Britain. Prev Vet Med. 2007, 81 (1-3): 21-37. 10.1016/j.prevetmed.2007.04.011.PubMedView ArticleGoogle Scholar
- Lindstrom T, Sisson SA, Lewerin SS, Wennergren U: Estimating animal movement contacts between holdings of different production types. Prev Vet Med. 2010, 95 (1-2): 23-31. 10.1016/j.prevetmed.2010.03.002.PubMedView ArticleGoogle Scholar
- Carlyle WJ: Distribution of Store Sheep from Markets in Scotland. Transactions of the Institute of British Geographers. 1978, 3 (2): 226-245. 10.2307/622203.View ArticleGoogle Scholar
- Volkova V, Savill NJ, Bessell PR, Woolhouse MEJ: Report on seasonality of movements and spatial distribution of sheep, cattle and pigs in Scotland. Report to Animal Health and Welfare Division of the Scottish Government's Rural and Environment Research and Analysis Directorate. 2008, ISBN 978 970 7559 1718 7551Google Scholar
- Green DM, Kao RR: Data quality of the Cattle Tracing System in Great Britain. Vet Rec. 2007, 161 (13): 439-443. 10.1136/vr.161.13.439.PubMedView ArticleGoogle Scholar
- Bigras-Poulin M, Thompson RA, Chriel M, Mortensen S, Greiner M: Network analysis of Danish cattle industry trade patterns as an evaluation of risk potential for disease spread. Prev Vet Med. 2006, 76 (1-2): 11-39. 10.1016/j.prevetmed.2006.04.004.PubMedView ArticleGoogle Scholar
- Sanson RL: A survey to investigate movements off sheep and cattle farms in New Zealand, with reference to the potential transmission of foot-and-mouth disease. N Z Vet J. 2005, 53 (4): 223-233. 10.1080/00480169.2005.36550.PubMedView ArticleGoogle Scholar
- Noremark M, Hakansson N, Lindstrom T, Wennergren U, Lewerin SS: Spatial and temporal investigations of reported movements, births and deaths of cattle and pigs in Sweden. Acta Vet Scand. 2009, 51: 37-10.1186/1751-0147-51-37.PubMed CentralPubMedView ArticleGoogle Scholar
- Natale F, Giovannini A, Savini L, Palma D, Possenti L, Fiore G, Calistri P: Network analysis of Italian cattle trade patterns and evaluation of risks for potential disease spread. Prev Vet Med. 2009, 92 (4): 341-350. 10.1016/j.prevetmed.2009.08.026.PubMedView ArticleGoogle Scholar
- Bigras-Poulin M, Barfod K, Mortensen S, Greiner M: Relationship of trade patterns of the Danish swine industry animal movements network to potential disease spread. Prev Vet Med. 2007, 80 (2-3): 143-165. 10.1016/j.prevetmed.2007.02.004.PubMedView ArticleGoogle Scholar
- Kao R, O'Reilly K, Bronsvoort B, Handel I, Zadoks R, Willoughby K, Milne C, Gunn G: Assessing the additional risk of FMD transmission from using field lairages at Scottish livestock markets. Report to Animal Health and Welfare Division of the Scottish Government's Rural and Environment Research and Analysis Directorate. 2008Google Scholar
- Thomson S: Foot and mouth disease review: Structure of the Scottish livestock industry. Special study report for The Scottish Government's Rural and Environment Research and Analysis Directorate. 2008, ISBN 978 970 7559 1739 7556Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.