Fig. 7

A Localized bleeding in renal cortex. Total damage extends approximately 200 µm × 100 µm and is consistent with mechanical trauma due to ultrasound. B Partial dissection of the inner layer of the ureter approximately 200 µm thick. This may be from the ultrasound exposure, but the lack of any bleeding is inconsistent with previously observed injury in vivo. It may also be from stone implantation or extraction during necropsy, or histologic processing artifacts. C Focal damage and localized denudation of urothelium. Focal damage is ≤ 400 µm from the urothelial surface. Stone fragments (black) are evident in the lumen. Again, the lack of bleeding is inconsistent with previously observed mechanical injury due to ultrasound exposure. Effects are potentially from stone implantation or histologic processing artifacts