Schiffman JD, Fisher PG, Gibbs P. Early detection of cancer: past, present, and future. Am Soc Clin Oncol Educ Book. 2015:57-65. https://doi.org/10.14694/EdBook_AM.2015.35.57. PMID: 25993143.
Bremer HD, Lattwein E, Renneker S, Lilliehook I, Ronnelid J, Hansson-Hamlin H. Identification of specific antinuclear antibodies in dogs using a line immunoassay and enzyme-linked immunosorbent assay. Vet Immunol Immunopathol. 2015;168(3–4):233–41.
Article
CAS
Google Scholar
Barker DA, Foale RD, Holmes MA, Demetriou JL. Survey of UK-based veterinary surgeons’ opinions on the use of surgery and chemotherapy in the treatment of canine high-grade mast cell tumour, splenic haemangiosarcoma and appendicular osteosarcoma. Vet Rec. 2016;179(22):572.
Article
CAS
Google Scholar
Bauden M, Pamart D, Ansari D, Herzog M, Eccleston M, Micallef J, et al. Circulating nucleosomes as epigenetic biomarkers in pancreatic cancer. Clin Epigenetics. 2015;7:106.
Article
Google Scholar
Rahier JF, Druez A, Faugeras L, Martinet JP, Géhénot M, Josseaux E, et al. Circulating nucleosomes as new blood-based biomarkers for detection of colorectal cancer. Clin Epigenetics. 2017;9:53.
Article
Google Scholar
Rasmussen L, Christensen IJ, Herzog M, Micallef J, Nielsen HJ, Danish Collaborative Group on Early Detection of Colorectal C. Circulating cell-free nucleosomes as biomarkers for early detection of colorectal cancer. Oncotarget. 2018;9(12):10247–58.
Article
Google Scholar
Cristiano S, Leal A, Phallen J, Fiksel J, Adleff V, Bruhm DC, et al. Genome-wide cell-free DNA fragmentation in patients with cancer. Nature. 2019;570(7761):385–9.
Article
CAS
Google Scholar
Mego M, Kalavska K, Karaba M, Minarik G, Benca J, Sedlackova T, Gronesova P, Cholujova D, Pindak D, Mardiak J, Celec P. Plasma Nucleosomes in Primary Breast Cancer. Cancers (Basel). 2020;12(9):2587. https://doi.org/10.3390/cancers12092587.
Kumar S, Guleria R, Singh V, Bharti AC, Mohan A, Das BC. Plasma nucleosome levels might predict response to therapy in patients with advanced non-small-cell lung cancer. Clin Lung Cancer. 2010;11(1):36–44.
Article
CAS
Google Scholar
Murtaza M, Caldas C. Nucleosome mapping in plasma DNA predicts cancer gene expression. Nat Genet. 2016;48(10):1105–6.
Article
CAS
Google Scholar
Ulz P, Thallinger GG, Auer M, Graf R, Kashofer K, Jahn SW, et al. Inferring expressed genes by whole-genome sequencing of plasma DNA. Nat Genet. 2016;48(10):1273–8.
Article
CAS
Google Scholar
Letendre JA, Goggs R. Determining prognosis in canine sepsis by bedside measurement of cell-free DNA and nucleosomes. J Vet Emerg Crit Care (San Antonio). 2018;28(6):503–11.
Article
Google Scholar
Letendre JA, Goggs R. Concentrations of plasma nucleosomes but Not Cell-Free DNA Are prognostic in dogs following trauma. Front Vet Sci. 2018;5:180.
Article
Google Scholar
Letendre JA, Goggs R. Measurement of plasma cell-free DNA concentrations in dogs with sepsis, trauma, and neoplasia. J Vet Emerg Crit Care (San Antonio). 2017;27(3):307–14.
Article
Google Scholar
Martiny P, Goggs R. Biomarker guided diagnosis of septic peritonitis in dogs. Front Vet Sci. 2019;6:208.
Article
Google Scholar
Monestier M, Novick KE, Karam ET, Chabanne L, Monier JC, Rigal D. Autoantibodies to histone, DNA and nucleosome antigens in canine systemic lupus erythematosus. Clin Exp Immunol. 1995;99(1):37–41.
Article
CAS
Google Scholar
Jeffery U, Kimura K, Gray R, Lueth P, Bellaire B, LeVine D. Dogs cast NETs too: canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. Vet Immunol Immunopathol. 2015;168(3–4):262–8.
Article
CAS
Google Scholar
Krogh AKH, Lyngby JG, Bjørnvad CR, Nielsen LN. Presence of nucleosomes in plasma and increased thrombin generation in dogs with acute and chronic gastroenteropathies. Res Vet Sci. 2021;135:504–10.
Article
CAS
Google Scholar
Wilson-Robles H, Miller T, Jarvis J, Terrell J, Dewsbury N, Kelly T, et al. Evaluation of nucleosome concentrations in healthy dogs and dogs with cancer. PLoS ONE. 2020;15(8):e0236228.
Article
CAS
Google Scholar
Dolan C, Miller T, Jill J, Terrell J, Kelly TK, Bygott T, et al. Characterizing circulating nucleosomes in the plasma of dogs with lymphoma. BMC Vet Res. 2021;17(1):276.
Article
CAS
Google Scholar
Wilson-Robles H, Miller T, Jarvis J, Terrell J, Kelly TK, Bygott T, et al. Characterizing circulating nucleosomes in the plasma of dogs with hemangiosarcoma. BMC Vet Res. 2021;17(1):231.
Article
CAS
Google Scholar
Morales-Molina A, Gambera S, Leo A, García-Castro J. Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma. J Immunother Cancer. 2021;9(3):e001703. https://doi.org/10.1136/jitc-2020-001703.
Nadauld LD, McDonnell CH 3rd, Beer TM, Liu MC, Klein EA, Hudnut A, Whittington RA, Taylor B, Oxnard GR, Lipson J, Lopatin M, Shaknovich R, Chung KC, Fung ET, Schrag D, Marinac CR. The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice. Cancers (Basel). 2021;13(14):3501. https://doi.org/10.3390/cancers13143501.
Flory A, Kruglyak KM, Tynan JA, McLennan LM, Rafalko JM, Fiaux PC, et al. Clinical validation of a next-generation sequencing-based multi-cancer early detection “liquid biopsy” blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study. PLoS ONE. 2022;17(4):e0266623.
Article
CAS
Google Scholar
Phan T, McMillan R, Skiadopoulos L, Walborn A, Hoppensteadt D, Fareed J, et al. Elevated extracellular nucleosomes and their relevance to inflammation in stage 5 chronic kidney disease. Int Angiol. 2018;37(5):419–26.
Article
Google Scholar
Cavalier E, Guiot J, Lechner K, Dutsch A, Eccleston M, Herzog M, et al. Circulating nucleosomes as potential markers to Monitor COVID-19 Disease Progression. Front Mol Biosci. 2021;8:600881.
Article
CAS
Google Scholar
Goswami J, MacArthur T, Bailey K, Spears G, Kozar RA, Auton M, et al. Neutrophil extracellular trap formation and Syndecan-1 shedding are increased after trauma. Shock. 2021;56(3):433–9.
CAS
PubMed
PubMed Central
Google Scholar
Carestia A, Frechtel G, Cerrone G, Linari MA, Gonzalez CD, Casais P, et al. NETosis before and after hyperglycemic control in Type 2 Diabetes Mellitus Patients. PLoS ONE. 2016;11(12):e0168647.
Article
Google Scholar
Yehya N, Fazelinia H, Lawrence GG, Spruce LA, Mai MV, Worthen GS, et al. Plasma nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome. Crit Care Med. 2021;49(7):1149–58.
CAS
PubMed
PubMed Central
Google Scholar
Penttilä AK, Rouhiainen A, Kylänpää L, Mustonen H, Puolakkainen P, Rauvala H, et al. Circulating nucleosomes as predictive markers of severe acute pancreatitis. J Intensive Care. 2016;4:14.
Article
Google Scholar
Goggs R. Effect of sample type on plasma concentrations of cell-free DNA and nucleosomes in dogs. Vet Rec Open. 2019;6(1):e000357.
Article
Google Scholar
Bowman RV, Yang IA, Semmler AB, Fong KM. Epigenetics of lung cancer. Respirology. 2006;11(4):355–65.
Article
Google Scholar
Holdenrieder S, Nagel D, Schalhorn A, Heinemann V, Wilkowski R, von Pawel J, et al. Clinical relevance of circulating nucleosomes in cancer. Ann N Y Acad Sci. 2008;1137:180–9.
Article
CAS
Google Scholar
Tufman A, Huber RM. Biological markers in lung cancer: a clinician’s perspective. Cancer Biomark. 2010;6(3–4):123–35.
Article
Google Scholar
Wang K, Shan S, Wang S, Gu X, Zhou X, Ren T. HMGB1-containing nucleosome mediates chemotherapy-induced metastasis of human lung cancer. Biochem Biophys Res Commun. 2018;500(3):758–64.
Article
CAS
Google Scholar
Arimura Y, Ikura M, Fujita R, Noda M, Kobayashi W, Horikoshi N, et al. Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res. 2018;46(19):10007–18.
CAS
PubMed
PubMed Central
Google Scholar
Wells JW, Evans CH, Scott MC, Rutgen BC, O’Brien TD, Modiano JF, et al. Arginase treatment prevents the recovery of canine lymphoma and osteosarcoma cells resistant to the toxic effects of prolonged arginine deprivation. PLoS ONE. 2013;8(1):e54464.
Article
CAS
Google Scholar
R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria; 2017. https://www.R-project.org/.
Xavier Robin NT, Alexandre Hainard, et al. . pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 2011;7(77).