Pluske JR, Hampson DJ, Williams IH. Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livest Prod Sci. 1997;51:215–36.
Richter JM, Schanbacher BL, Huang H, Xue JJ, Bauer JA, Giannone PJ. Lipopolysaccharide binding protein enables intestinal epithelial restituti. J Pediatr Gastroenterol Nutr. 2012;54:639–44.
Ritchie JM, Rui HP, Zhou XH, Iida T, Kodoma T, Ito S, et al. Inflammation and disintegration of intestinal villi in an experimental model for Vibrio parahaemolyticus-induced diarrhea. PLoS Pathog. 2012;8:e1002593.
Snel J, Harmsen HJM, Wielen PWJJ, Williams BA, Blok MC, Vahl HA, et al. Dietary strategies to influence the gastro-intestinal microflora of young animals, and its potential to improve intestinal health. J Chem Phys. 2002;65:5083–92.
Argenzio RA, Liacos JA, Levy ML, Meuten DJ, Lecce JG, Powell DW. Villous atrophy, crypt hyperplasia, cellular infiltration, and impaired glucose-Na absorption in enteric cryptosporidiosis of pigs. Gastroenterology. 98(5):1129–40. https://doi.org/10.1016/0016-5085(90)90325-u.
Wang L, Zhou J, Hou YQ, Yi D, Ding BY, Xie JQ, et al. N-acetylcysteine supplementation alleviates intestinal injury in piglets infected by porcine epidemic diarrhea virus. Amino Acids. 2017;49:1931–43.
Zheng L, Duarte ME, Sevarolli Loftus A, Kim SW. Intestinal health of pigs upon weaning: challenges and nutritional intervention. Front Vet Sci. 2021;8:628258.
Wei X, Tsai T, Howe S, Zhao J. Weaning induced gut dysfunction and nutritional interventions in nursery pigs: a partial review. Animals (Basel). 2021;11(5):1279.
Moeser AJ, Pohl CS, Rajput M. Weaning stress and gastrointestinal barrier development: implications for lifelong gut health in pigs. Anim Nutr. 2017;3(4):313–21.
Ji FJ, Wang LX, Yang HS, Hu A, Yin YL. Review: the roles and functions of glutamine on intestinal health and performance of weaning pigs. Animal. 2019;13:2727–35.
Upadhaya SD, Laguna FB, Bertaud B, Kim IH. Multi-strain yeast fraction product supplementation can alleviate weaning stress and improve performance and health of piglets raised under low sanitary conditions. J Sci Food Agric. 2019;99:6076–83.
Köck R, Cuny C. Multidrug-resistant bacteria in animals and humans. Med Klin Intensivmed Notfmed. 2020;115:189–97.
Yun J, Olkkola S, Hänninen ML, Oliviero C, Heinonen M. The effects of amoxicillin treatment of newborn piglets on the prevalence of hernias and abscesses, growth and ampicillin resistance of intestinal coliform bacteria in weaned pigs. PLoS One. 2017;15(12):e0172150.
Xuan ZN, Kim JD, Heo KN, Jung HJ, Lee JH, Han YK, et al. Study on the development of a probiotics complex for weaned pigs. Asian Australas J Animal Sci. 2001;14:1425–8.
Singh VP, Sharma J, Babu S, Rizwanulla SA. Role of probiotics in health and disease: a review. J Pak Med Assoc. 2013;63:253–7.
Hou Y, Wang L, Zhang W, Yang Z, Ding B, Zhu H, et al. Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide. Amino Acids. 2012;43:1233–42.
Bhandari SK, Xu B, Nyachoti CM, Giesting DW, Krause DO. Evaluation of alternatives to antibiotics using an Escherichia coli K88+ model of piglet diarrhea: effects on gut microbial ecology. J Anim Sci. 2008;86:836–47.
Zhang YY, Wu T, Chen ZQ, Meng YX, Zhu ZK, Wang Q, et al. Dietary supplementation with Enterococcus faecium R1 attenuates intestinal and liver injury in piglets challenged by lipopolysaccharide. Animals. 2021;11:1424.
Bon ML, Davies HE, Glynn C, Thompson C, Madden M, Wiseman J, et al. Influence of probiotics on gut health in the weaned pig. Livest Sci. 2010;133:179–81.
Wang JQ, Yin FG, Zhu C, Yu H, Niven SJ, DeLange CFM, et al. Evaluation of probiotic bacteria or their effects on the growth performance and intestinal microbiota of newly-weaned pigs fed fermented high-moisture maize. Livest Sci. 2012;145:79–86.
Wang M, Pan, Hongchun, Liu, & Hong, et al. Physicochemical properties, characterization, and antioxidant activity of sodium ferric gluconate complex. Food Sci Technol Res. 2016;22(5):639–46.
Guo Y, Shi Y, Li F, Chen J, Zhao Z. Effects of sodium gluconate and phytase on performance and bone characteristics in broiler chickers. Anim Feed Sci Technol. 2009;150:270–82.
Junqueira OM, Duarte KF, Garcia EA, Sgavioli S, Molino ADB. Effect of sodium gluconate on performance，carcass characteristics, and intestinal morphometry of broilers from 22 to 42 days of age. Acta Scientiarum Animal Sci. 2012;34:35–40.
Hiroyuki T, Ryouko K. Sodium gluconate and potassium gluconate as substitutes for sodium chloride in bread making. Food Sci Technol Res. 2002;8:75–9.
Rafacz-Livingston KA, Parsons CM, Jungk RA. The effects of various organic acids on phytate phosphorus utilization in chicks. Poult Sci. 2005;84:1356.
Koyama H, Okada M, Okumura T, Mishiba T, Yamada K, Tsukahara T, et al. Effect of dietary sodium gluconate on growth, prevention of Escherichia coli infection and fecal malodor of piglets. J Animal Hygiene. 2003;29:113–22.
Wu T, Lv Y, Li XN, Zhao D, Yi D, Wang L, et al. Establishment of a recombinant Escherichia coli-induced piglet diarrhea model. Front Biosci (Landmark Ed). 2018;23:1517–34.
Spreeuwenberg MA, Verdonk JM, Gaskins HR, Verstegen MW. Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning. J Nutr. 2001;131:1520–7.
Yi D, Li BC, Hou YQ, Wang L, Zhao D, Chen HB, et al. Dietary supplementation with an amino acid blend enhances intestinal function in piglets. Amino Acids. 2018;50:1089–100.
Wu MJ, Zhang Q, Yi D, Wu T, Chen HB, Guo SS, et al. Quantitative proteomic analysis reveals antiviral and anti-inflammatory effects of puerarin in piglets infected with porcine epidemic diarrhea virus. Front Immunol. 2020;11:169.
Davies J, Davies D. Origins and evolution of antibiotic resistance. Microbiol. Mol. Biol. Rev. 74(3):417–33. https://doi.org/10.1128/MMBR.00016-10.
Wu MJ, Yi D, Zhang Q, Wu T, Yu K, Peng M, et al. Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus. Sci Rep. 2021;11:6552.
Wang L, Hou Y, Yi D, Ding B, Zhao D, Wang Z, et al. Beneficial roles of dietary oleum cinnamomi in alleviating intestinal injury. Front. Biosci. (Landmark Ed.). 2015;20:814–28.
Westendorp WF, Vermeij JD, Zock E, Hooijenga IJ, Kruyt ND, Bosboom HJL, et al. The preventive antibiotics in stroke study (PASS): a pragmatic randomised open-label masked endpoint clinical trial. Lancet. 2015;385:1519–26.
Kong XF, Wu GY, Liao YP, Hou ZP, Liu HJ, Yin FG, et al. Dietary supplementation with Chinese herbal ultra-fine powder enhances cellular and humoral immunity in early-weaned piglets. Livest Sci. 2007;108:94–8.
Hao Y, Piao X, Piao X. Saikosaponin-d inhibits β-conglycinin induced activation of rat basophilic leukemia-2H3 cells. Int Immunopharmacol. 2012;13:257–63.
Windisch W, Schedle K, Plitzner C, Kroismayr A. Use of phytogenic products as feed additives for swine and poultry. J Anim Sci. 2008;86:14018.
Kang P, Zhang L, Hou Y, Ding B, Yi D, Wang L, et al. Effects of L-proline on the growth performance, and blood parameters in weaned lipopolysaccharide (LPS)-challenged pigs. Asian-Australas J Anim Sci. 2014;27(8):1150–6.
Zhao ZP, Yang Z, Lin WD, Wang WY, Yang J, Jin WJ, et al. The rate of co-infection for piglet diarrhea viruses in China and the genetic characterization of porcine epidemic diarrhea virus and porcine kobuvirus. Acta Virol. 2016;60:55–61.
Makino S, Watarai M, Tabuchi H, Shirahata T, Furuoka H, Kobayashi Y, et al. Genetically modified Shiga toxin 2e (Stx2e) producing Escherichia coli is a vaccine candidate for porcine edema disease. Microb Pathog. 2001;31:1–8.
Macleod DL, Gyles CL, Wilcock BP. Reproduction of edema disease of swine with purified Shiga-like toxin-II variant. Vet Pathol. 1991;28:66–73.
Oanh TKN, Nguyen VK, Greve HD, Goddeeris BM. Protection of piglets against edema disease by maternal immunization with Stx2e toxoid. Infection & Immunity. 2012;80:469–73.
Johansen M, Andresen LO, Jorsal SE, Thomsen LK, Waddell TE, Gyles CL. Prevention of edema disease in pigs by vaccination with verotoxin 2e toxoid. Revue Canadienne De Recherche Vétérinaire. 1997;61:280–5.
Wu T, Li K, Yi D, Wang L, Zhao D, Lv Y, et al. Dietary supplementation with trihexanoin enhances intestinal function of weaned piglets. Int J Mol Sci. 2018;19:3277.
Han J, Liu YL, Fan W, Chao J, Hou YQ, Yin YL, et al. Dietary L-arginine supplementation alleviates immunosuppression induced by cyclophosphamide in weaned pigs. Amino Acids. 2009;37:643–51.
Liu Y, Jing L, Shi J, Hou Y, Zhu H, Zhao S, et al. Increased expression of the peroxisome proliferator-activated receptor γ in the immune system of weaned pigs after Escherichia coli lipopolysaccharide challenge. Vet Immunol Immunopathol. 2008;124:82–92.
Wu T, Shi Y, Zhang Y, Zhang M, Zhang L, Ma Z, et al. Lactobacillus rhamnosus LB1 alleviates Enterotoxigenic Escherichia coli-induced adverse effects in piglets by improving host immune response and anti-oxidation stress and restoring intestinal integrity. Front Cell Infect Microbiol. 2021;11:724401.
Jin LZ, Marquardt RR, Zhao X. A strain of Enterococcus faecium (18C23) inhibits adhesion of enterotoxigenic Escherichia coli K88 to porcine small intestine mucus. Appl Environ Microbiol. 2000;66(10):4200–4.
Thomson ABR, Keelan M, Thiesen A, Clandinin MT, Ropeleski M, Wild GE. Small bowel review diseases of the small intestine. Digestive Dis Sci. 2001;46:2555–66.
Pluske JR, Williams IH, Aherne FX. Maintenance of villous height and crypt depth in piglets by providing continuous nutrition after weaning. Anim Sci. 2010;62:131–44.
Huth ME, Ricci AJ, Cheng AG. Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. Int J Otolaryngol. 2011;937861.
Fang YZ, Yang S, Wu G. Free radicals, antioxidants, and nutrition. Nutrition. 2002;18:872–9.
Reumaux D, Boer M, Meijer AB, Duthilleul P, Roos D. Natural and disease associated anti-myeloperoxidase (MPO) autoantibodies. Autoimmun Rev. 2008;7:421–5.
Wang H, Li C, Peng M, Wang L, Zhao D, Wu T, et al. N-Acetylcysteine improves intestinal function and attenuates intestinal autophagy in piglets challenged with β-conglycinin. Sci Rep. 2021;11(1):1261.
Mitsuoka T. Intestinal flora and human health. Asia Pac J Clin Nutr. 1996;5:2–9.
Heeney DD, Gareau MG, Marco ML. Intestinal Lactobacillus in health and disease, a driver or just along for the ride? Curr Opin Biotechnol. 2018;49:140–7.
Suzuki K, Fagarasan S. How host-bacterial interactions lead to IgA synthesis in the gut. Trends Immunol. 2008;29(11):523–31.
Orrhage K, Nord CE. Bifidobacteria and lactobacilli in human health. Drugs Under Exp Clin Res. 2000;26(3):95–111.