Fig. 9

A Gross image of the enucleated globe showing multifocal reticular shaped depigmented lesions in a 4-year-old, spayed female, Siberian Husky (case 1, OS), the centers of which showed pigment deposits involving the inferior fundus. B A broad, non-perforate, sheet-like band of uveal stroma (asterisk) bridges from the base of the iris to the terminal arborization of Descemet's membrane and extends over the collapsed ciliary cleft. C Histopathologic examination of biopsied nose pad showed variable melanin pigment presence within the basal keratinocyte layers of the epidermis (melanin indicated by arrow). D Histopathologic evaluation OS revealed severe diffuse inner to segmental profound (arrows) retinal atrophy which was consistent with the OCT findings in the fellow eye (OD), which never had a documented IOP spike. E There is multifocal loss of the retinal pigment epithelium and adherence of the neural retina to Bruch's membrane (arrow). The choroid is thin and atrophic. Hematoxylin and eosin (H&E) stain. Scale bars for B, D, and E = 50 μm and for C = 20 μm