Bidarimath M, Khalaj K, Kridli RT, Kan FW, Koti M, Tayade C. Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: a new paradigm for conceptus-endometrial cross-talk. Sci Rep. 2017;7:40476.
Article
CAS
PubMed
PubMed Central
Google Scholar
Barranco I, Padilla L, Parrilla I, Alvarez-Barrientos A, Perez-Patino C, Pena FJ, et al. Extracellular vesicles isolated from porcine seminal plasma exhibit different tetraspanin expression profiles. Sci Rep. 2019;9(1):11584.
Article
PubMed
PubMed Central
Google Scholar
van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.
Article
PubMed
Google Scholar
Robinson DG, Ding Y, Jiang L. Unconventional protein secretion in plants: a critical assessment. Protoplasma. 2016;253(1):31–43.
Article
CAS
PubMed
Google Scholar
Perrini C, Strillacci MG, Bagnato A, Esposti P, Marini MG, Corradetti B, et al. Microvesicles secreted from equine amniotic-derived cells and their potential role in reducing inflammation in endometrial cells in an in-vitro model. Stem Cell Res Ther. 2016;7(1):169.
Article
PubMed
PubMed Central
Google Scholar
Nederveen JP, Warnier G, Di Carlo A, Nilsson MI, Tarnopolsky MA. Extracellular vesicles and Exosomes: insights from exercise science. Front Physiol. 2020;11:604274.
Article
PubMed
Google Scholar
Cocucci E, Racchetti G, Meldolesi J. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009;19(2):43–51.
Article
CAS
PubMed
Google Scholar
French KC, Antonyak MA, Cerione RA. Extracellular vesicle docking at the cellular port: extracellular vesicle binding and uptake. Semin Cell Dev Biol. 2017;67:48–55.
Article
CAS
PubMed
PubMed Central
Google Scholar
Battistelli M, Falcieri E. Apoptotic bodies: particular extracellular vesicles involved in intercellular communication. Biology. 2020;9(1)21. https://doi.org/10.3390/biology9010021.
Alminana C, Corbin E, Tsikis G, Alcantara-Neto AS, Labas V, Reynaud K, et al. Oviduct extracellular vesicles protein content and their role during oviduct-embryo cross-talk. Reproduction. 2017;154(3):153–68.
Article
PubMed
Google Scholar
Kumar D, Gupta D, Shankar S, Srivastava RK. Biomolecular characterization of exosomes released from cancer stem cells: possible implications for biomarker and treatment of cancer. Oncotarget. 2015;6(5):3280–91.
Article
PubMed
Google Scholar
Kalra H, Drummen GP, Mathivanan S. Focus on extracellular vesicles: introducing the next small big thing. Int J Mol Sci. 2016;17(2):170.
Article
PubMed
PubMed Central
Google Scholar
Rana S, Yue S, Stadel D, Zoller M. Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection. Int J Biochem Cell Biol. 2012;44(9):1574–84.
Article
CAS
PubMed
Google Scholar
Aliotta JM, Pereira M, Johnson KW, de Paz N, Dooner MS, Puente N, et al. Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription. Exp Hematol. 2010;38(3):233–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Caobi A, Nair M, Raymond AD. Extracellular vesicles in the pathogenesis of viral infections in humans. Viruses. 2020;12(10)1200. https://doi.org/10.3390/v12101200.
Tian J, Casella G, Zhang Y, Rostami A, Li X. Potential roles of extracellular vesicles in the pathophysiology, diagnosis, and treatment of autoimmune diseases. Int J Biol Sci. 2020;16(4):620–32.
Article
CAS
PubMed
PubMed Central
Google Scholar
Traub-Dargatz JL, Salman MD, Voss JL. Medical problems of adult horses, as ranked by equine practitioners. J Am Vet Med Assoc. 1991;198(10):1745–7.
CAS
PubMed
Google Scholar
Marth CD, Young ND, Glenton LY, Noden DM, Browning GF, Krekeler N. Deep sequencing of the uterine immune response to bacteria during the equine oestrous cycle. BMC Genomics. 2015;16:934.
Article
PubMed
PubMed Central
Google Scholar
Riddle WT, LeBlanc MM, Stromberg AJ. Relationships between uterine culture, cytology and pregnancy rates in a thoroughbred practice. Theriogenology. 2007;68(3):395–402.
Article
CAS
PubMed
Google Scholar
Morris LHA, McCue PM, Aurich C. Equine endometritis: a review of challenges and new approaches. Reproduction. 2020;160(5):R95–R110.
Article
CAS
Google Scholar
LeBlanc MM, Causey RC. Clinical and subclinical endometritis in the mare: both threats to fertility. Reprod Domest Anim. 2009;44(Suppl 3):10–22.
Article
PubMed
Google Scholar
Christoffersen M, Woodward E, Bojesen AM, Jacobsen S, Petersen MR, Troedsson MH, et al. Inflammatory responses to induced infectious endometritis in mares resistant or susceptible to persistent endometritis. BMC Vet Res. 2012;8:41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Woodward EM, Christoffersen M, Campos J, Betancourt A, Horohov D, Scoggin KE, et al. Endometrial inflammatory markers of the early immune response in mares susceptible or resistant to persistent breeding-induced endometritis. Reproduction. 2013;145(3):289–96.
Article
CAS
PubMed
Google Scholar
Canisso IF, Segabinazzi L, Fedorka CE. Persistent breeding-induced Endometritis in mares - a multifaceted challenge: from clinical aspects to Immunopathogenesis and pathobiology. Int J Mol Sci. 2020;21(4)1432. https://doi.org/10.3390/ijms21041432.
Kohne M, Kuhlmann M, Tonissen A, Martinsson G, Sieme H. Diagnostic and treatment practices of equine Endometritis-a questionnaire. Front Vet Sci. 2020;7:547.
Article
PubMed
PubMed Central
Google Scholar
Canisso IF, Stewart J, Coutinho da Silva MA. Endometritis: managing persistent post-breeding endometritis. Vet Clin N Am Equine Pract. 2016;32(3):465–80.
Article
Google Scholar
El-Shalofy AS, Derbala MK, Asfour HA, Eissa HM, Aly AB. Infectious endometritis in Arabian mares: an updated clinical investigation of uterine microbial isolates, antimicrobial sensitivities and fertility in Egypt. Thai J Vet Med. 2021;51(1):177–84.
Google Scholar
Ibrahim S, Szostek-Mioduchowska A, Skarzynski D. Expression profiling of selected miRNAs in equine endometrium in response to LPS challenge in vitro: a new understanding of the inflammatory immune response. Vet Immunol Immunopathol. 2019;209:37–44.
Article
CAS
PubMed
Google Scholar
Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Alterations in the expression profile of serum miR-155, miR-223, miR-17, miR-200a, miR-205, as well as levels of interleukin 6, and prostaglandins during Endometritisin Arabian mares. Vet Sci. 2021;8(98). https://doi.org/10.3390/vetsci8060098.
Orsi NM, Tribe RM. Cytokine networks and the regulation of uterine function in pregnancy and parturition. J Neuroendocrinol. 2008;20(4):462–9.
Article
CAS
PubMed
Google Scholar
Fumuso E, Giguere S, Wade J, Rogan D, Videla-Dorna I, Bowden RA. Endometrial IL-1beta, IL-6 and TNF-alpha, mRNA expression in mares resistant or susceptible to post-breeding endometritis. Effects of estrous cycle, artificial insemination and immunomodulation. Vet Immunol Immunopathol. 2003;96(1–2):31–41.
Article
CAS
PubMed
Google Scholar
Hedia M, Ibrahim S, Mahmoud K, Ahmed Y, Ismail S, El-Belely M. Hemodynamic changes in cytokines, chemokines, acute phase proteins and prostaglandins in mares with subclinical endometritis. Theriogenology. 2021;171:38–43.
Article
CAS
PubMed
Google Scholar
Aiello A, Giannessi F, Percario ZA, Affabris E. An emerging interplay between extracellular vesicles and cytokines. Cytokine Growth Factor Rev. 2020;51:49–60.
Article
CAS
PubMed
Google Scholar
da Silveira JC, Veeramachaneni DN, Winger QA, Carnevale EM, Bouma GJ. Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: a possible new form of cell communication within the ovarian follicle. Biol Reprod. 2012;86(3):71.
Article
PubMed
Google Scholar
Klohonatz KM, Cameron AD, Hergenreder JR, da Silveira JC, Belk AD, Veeramachaneni DN, et al. Circulating miRNAs as potential alternative cell signaling associated with maternal recognition of pregnancy in the Mare. Biol Reprod. 2016;95(6):124.
Article
PubMed
Google Scholar
Alminana C, Rudolf Vegas A, Tekin M, Hassan M, Uzbekov R, Frohlich T, et al. Isolation and characterization of equine uterine extracellular vesicles: a comparative methodological study. Int J Mol Sci. 2021;22(2)979. https://doi.org/10.3390/ijms22020979.
Capra E, Lange-Consiglio A. The biological function of extracellular vesicles during fertilization, early embryo-maternal crosstalk and their involvement in reproduction: review and overview. Biomolecules. 2020;10(11)1510. https://doi.org/10.3390/biom10111510.
Lange-Consiglio A, Funghi F, Cantile C, Idda A, Cremonesi F, Riccaboni P. Case report: use of amniotic microvesicles for regenerative medicine treatment of a Mare with chronic endometritis. Front Vet Sci. 2020;7:347.
Article
PubMed
PubMed Central
Google Scholar
Drizi A, Djokovic D, Lagana AS, van Herendael B. Impaired inflammatory state of the endometrium: a multifaceted approach to endometrial inflammation. Current insights and future directions. Przegl Menopauzalny Menopause Rev. 2020;19(2):90–100.
Article
Google Scholar
Amorim MD, Gartley CJ, Foster RA, Hill A, Scholtz LE, Hayes A, et al. Comparison of clinical signs, endometrial culture, endometrial cytology, uterine low-volume lavage, and uterine biopsy and combinations in the diagnosis of equine endometritis. J Equine Vet Sci. 2016;44:54–61.
Article
Google Scholar
Lobb RJ, Becker M, Wen SW, Wong CS, Wiegmans AP, Leimgruber A, et al. Optimized exosome isolation protocol for cell culture supernatant and human plasma. J Extracell Vesicles. 2015;4:27031.
Article
PubMed
Google Scholar
Chuo ST, Chien JC, Lai CP. Imaging extracellular vesicles: current and emerging methods. J Biomed Sci. 2018;25(1):91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ludwig N, Whiteside TL, Reichert TE. Challenges in exosome isolation and analysis in health and disease. Int J Mol Sci. 2019;20(19)4684. https://doi.org/10.3390/ijms20194684.
Isola AL, Chen S. Exosomes: the messengers of health and disease. Curr Neuropharmacol. 2017;15(1):157–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Properzi F, Logozzi M, Fais S. Exosomes: the future of biomarkers in medicine. Biomark Med. 2013;7(5):769–78.
Article
CAS
PubMed
Google Scholar
Gurunathan S, Kang MH, Jeyaraj M, Qasim M, Kim JH. Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells. 2019;8(4)307. https://doi.org/10.3390/cells8040307.
Qi J, Liu Q, Reisdorf RL, Boroumand S, Behfar A, Moran SL, et al. Characterization of a purified exosome product and its effects on canine flexor tenocyte biology. J Orthop Res. 2020;38(8):1845–55.
Article
CAS
PubMed
Google Scholar
Jankovicova J, Secova P, Michalkova K, Antalikova J. Tetraspanins, more than markers of extracellular vesicles in reproduction. Int J Mol Sci. 2020;21(20)7568. https://doi.org/10.3390/ijms21207568.
Weber B, Franz N, Marzi I, Henrich D, Leppik L. Extracellular vesicles as mediators and markers of acute organ injury: current concepts. Eur J Trauma Emerg Surg. 2021. https://doi.org/10.1007/s00068-021-01607-1.
Kasimanickam RK, Kasimanickam VR, Olsen JR, Jeffress EJ, Moore DA, Kastelic JP. Associations among serum pro- and anti-inflammatory cytokines, metabolic mediators, body condition, and uterine disease in postpartum dairy cows. Reprod Biol Endocrinol. 2013;11:103.
Article
PubMed
PubMed Central
Google Scholar
Nasreldin N, Ali FAZ, Abd-Elhafeez HH, Hassan M, El-Zeftawy M, Senosy W. Characterization of immunological, biochemical and inflammatory response of clinical and subclinical endometritis in ewes in the subtropics. Anim Reprod Sci. 2020;219:106541.
Article
CAS
PubMed
Google Scholar
Ferro-Novick S, Brose N. Nobel 2013 physiology or medicine: traffic control system within cells. Nature. 2013;504(7478):98.
Article
CAS
PubMed
Google Scholar
Hurtgen JP. Pathogenesis and treatment of endometritis in the mare: a review. Theriogenology. 2006;66(3):560–6.
Article
CAS
PubMed
Google Scholar
Amaral AS. New insights on the inhibition of neutrophil extracellular traps enzymes in equine endometrium. PhD thesis, Faculty of Veterinary Medicine, University of Lisbon, Portugal 2021.
Bohn AA, Ferris RA, McCue PM. Comparison of equine endometrial cytology samples collected with uterine swab, uterine brush, and low-volume lavage from healthy mares. Vet Clin Pathol. 2014;43(4):594–600.
Article
PubMed
Google Scholar
Nielsen JM. Endometritis in the mare: a diagnostic study comparing cultures from swab and biopsy. Theriogenology. 2005;64(3):510–8.
Article
PubMed
Google Scholar
Aguilar J, Hanks M, Shaw DJ, Else R, Watson E. Importance of using guarded techniques for the preparation of endometrial cytology smears in mares. Theriogenology. 2006;66(2):423–30.
Article
PubMed
Google Scholar
Thery C, Amigorena S, Raposo G, Clayton A: Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol 2006, Chapter 3:Unit 3 22.
Wu Y, Deng W, Klinke DJ. Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers. Analyst. 2015;140(19):6631–42.
Article
CAS
PubMed
PubMed Central
Google Scholar