Table 1 Proteins identified in the tear of healthy and infected cats

Allergen Fel d 4 OS=Felis catus PE = 1 SV = 1

ALL4_FELCA

21,580

11,292/346

14,539/383

12,265/350

12,427/316

6378/186

1968/92

9444/ 245

11,693/283

11,127/302

Serum albumin OS=Felis catus GN = ALB PE = 1 SV = 1

ALBU_FELCA

70,611

2740/76

4467/119

3544/93

2867/71

2245/61

933/30

3460/89

3646/93

2601/65

Aldehyde dehydrogenase, dimeric NADP-preferring OS=Canis lupus familiaris GN = ALDH3A1 PE = 2

AL3A1_CANLF

51,193

509/17

731/23

598/17

779/26

647/16

266/7

842/23

775/24

606/20

Lactoperoxidase OS=Bos taurus GN = LPO PE = 1

PERL_BOVIN

81,504

427/18

783/28

562/19

1031/36

535/17

299/9

586/23

684/23

585/21

Lactotransferrin OS=Bos taurus GN = LTF PE = 1 SV = 2

TRFL_BOVIN

80,002

410/15

667/27

534/19

643/20

604/23

283/18

542/18

699/21

450/17

Lactotransferrin (Fragment) OS = Equus caballus GN = LTF PE = 1 SV = 1

TRFL_HORSE

77,938

184/7

238/11

283/12

275/8

425/14

189/6

237/9

343/11

184/8

Inhibitor of carbonic anhydrase OS=Sus scrofa GN=ICA PE = 1

ICA_PIG

79,636

406/10

471/10

375/6

877/17

911/20

187/4

695/15

777/16

514/10

Major allergen I polypeptide chain 1 OS=Felis catus GN=CH1 PE = 1 SV = 2

FEL1A_FELCA

10,364

353/7

781/12

709/9

725/13

ND

ND

219/3

746/11

487/9

Trypsin OS=Sus scrofa PE = 1 SV = 1

TRYP_PIG

25,078

255/7

260/11

289/8

459/13

196/8

184/6

255/8

527/12

212/6

Actin, plasmodial isoform OS=Physarum polycephalum GN = ARDA PE = 1

ACTA_PHYPO

42,001

227/10

ND

ND

ND

ND

ND

ND

ND

ND

Deleted in malignant brain tumors 1 protein OS=Oryctolagus cuniculus GN=Dmbt1 PE = 1

DMBT1_RABIT

177,328

201/4

293/5

259/4

504/9

327/6

276/7

393/7

167/3

ND

Haptoglobin OS = Ateles geoffroyi GN=HP PE = 2

HPT_ATEGE

38,964

200/11

ND

ND

ND

ND

ND

ND

ND

ND

Haptoglobin OS=Canis lupus familiaris GN=HP PE = 1

HPT_CANLF

36,890

128/7

198/7

122/3

265/10

129/5

103/5

218/9

217/23

106/7

Glutathione S-transferase P OS=Bos taurus GN = GSTP1 PE = 1

GSTP1_BOVIN

23,826

190/4

303/6

375/7

407/5

116/2

ND

289/4

573/8

282/4

Ig kappa chain V region GOM OS=Canis lupus familiaris PE = 1 SV = 1

KV1_CANLF

12,112

158/2

428/6

178/2

ND

ND

ND

205/3

429/5

324/4

Ig lambda chain C region OS=Sus scrofa PE = 1

LAC_PIG

11,168

155/8

435/18

361/15

105/4

ND

ND

241/12

421/16

347/11

Polymeric immunoglobulin receptor OS=Bos taurus GN=PIGR PE = 2

PIGR_BOVIN

83,695

150/6

126/6

118/5

ND

106/6

ND

224/12

239/8

ND

Ovostatin homolog 2 OS=Homo sapiens GN=OVOS2 PE = 2 SV = 2

OVOS2_HUMAN

162,517

135/5

271/9

208/6

329/12

316/14

302/15

216/8

226/9

212/8

Retinal dehydrogenase 1 OS=Oryctolagus cuniculus GN = ALDH1A1 PE = 1

AL1A1_RABIT

54,933

110/2

ND

ND

ND

ND

ND

ND

ND

142/4

Ovostatin homolog OS = Mus musculus GN=Ovos PE = 2 SV = 2

OVOS_MOUSE

163,607

108/6

163/11

ND

161/9

215/11

208/11

150/9

162/10

124/7

Immunoglobulin heavy variable 3–15 OS=Homo sapiens GN=IGHV3–15 PE = 3

HV315_HUMAN

13,089

105/4

239/12

112/7

115/4

178/6

102/4

214/8

ND

108/5

Glutathione S-transferase P OS=Bos taurus GN = GSTP1 PE = 1

GSTP1_CRILO

23,851

102/2

198/5

155/4

ND

160/4

ND

174/4

170/4

ND

Lactotransferrin OS=Camelus dromedarius GN = LTF PE = 1

TRFL_CAMDR

79,158

ND

608/22

509/17

725/19

ND

ND

ND

746/23

ND

Actin-10 OS=Dyctiostelium discoideum GN = act10 PE = 1 SV = 1

ACT10_DICDI

41,948

ND

312/15

ND

ND

ND

ND

ND

342/23

368/19

Actin, muscle-type OS = Molgula oculata PE = 3 SV = 1

ACT2_MOLOC

42,521

ND

274/13

ND

ND

ND

ND

487/17

ND

ND

Aldehyde dehydrogenase, cytosolic 2 (Fragment) OS = Macroscelides proboscideus PE = 2

ALDH2_MACPR

26,841

ND

274/10

370/9

ND

ND

ND

ND

207/5

ND

Haptoglobin OS=Bos taurus GN=HP PE = 2 SV = 1

HPT_BOVIN

45,629

ND

231/12

158/7

ND

288/17

253/14

186/12

180/10

118/10

Selenium-binding protein 1 OS = Rattus norvegicus GN=Selenbp1 PE = 1 SV = 1

SBP1_RAT

53,069

ND

256/9

ND

177/8

ND

ND

297/11

ND

ND

Alpha-enolase OS=Homo sapiens GN = ENO1 PE = 1 SV = 2

ENOA_HUMAN

47,481

ND

220/8

179/5

173/7

ND

ND

163/6

151/6

177/6

14–3-3 protein sigma OS=Bos taurus GN=SFN PE = 2

1433S_BOVIN

27,946

ND

133/10

119/3

172/6

140/7

ND

325/14

236/12

194/7

Malate dehydrogenase OS = Myxococcus xanthus GN = mdh PE = 3 SV = 1

MDH_MYXXA

33,194

ND

120/14

ND

101/16

ND

ND

ND

106/19

118/14

Serotransferrin OS = Mus musculus GN = Tf PE = 1 SV = 1

TRFE_MOUSE

78,841

ND

109/6

ND

108/6

141/7

134/7

133/6

105/6

ND

14–3-3 protein zeta/delta OS=Bos taurus GN=YWHAZ PE = 1 SV = 1

1433Z_BOVIN

27,899

ND

ND

104/3

ND

ND

ND

ND

ND

ND

Actin, muscle OS = Manduca sexta PE = 2 SV = 1

ACT_MANSE

42,149

ND

ND

213/15

559/15

ND

ND

ND

ND

ND

Selenium-binding protein 1 OS=Homo sapiens GN=SELENBP1 PE = 1

SBP1_HUMAN

52,928

ND

ND

160/4

ND

113/3

108/3

ND

232/10

142/4

Retinal dehydrogenase 1 OS=Homo sapiens GN = ALDH1A1 PE = 1 SV = 2

AL1A1_HUMAN

55,454

ND

ND

254/6

ND

ND

ND

ND

121/3

ND

Lactotransferrin OS=Sus scrofa GN = LTF PE = 1 SV = 3

TRFL_PIG

79,514

ND

ND

126/7

ND

ND

ND

111/7

103/5

ND

Keratin, type II cytoskeletal 1 OS=Homo sapiens GN=KRT1 PE = 1

K2C1_HUMAN

66,170

ND

ND

ND

296/12

298/9

ND

ND

ND

ND

Phosphoglycerate mutase 1 OS=Bos taurus GN=PGAM1 PE = 2

PGAM1_BOVIN

28,948

ND

ND

ND

113/4

ND

ND

ND

ND

ND

Actin, cytoplasmic 1 OS=Bos mutus grunniens GN = ACTB PE = 2

ACTB_BOSMU

42,064

ND

ND

ND

ND

248/18

ND

ND

ND

ND

Elongation factor 1-alpha, somatic form OS = Xenopus laevis GN = eef1as PE = 2

EF1A0_XENLA

50,524

ND

ND

ND

ND

142/6

ND

ND

ND

ND

Retinal dehydrogenase 1 OS=Bos taurus GN = ALDH1A1 PE = 1 SV = 3

AL1A1_BOVIN

55,398

ND

ND

ND

ND

128/2

ND

ND

ND

ND

Lactoperoxidase OS=Homo sapiens GN = LPO PE = 1 SV = 2

PERL_HUMAN

81,149

ND

ND

ND

ND

341/11

424/13

ND

ND

ND

Actin-17 OS=Dictyostelium discoideum GN = act17 PE = 3

ACT17_DICDI

41,773

ND

ND

ND

ND

ND

177/10

ND

ND

ND

Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN = TEF PE = 3

EF1A_BLAAD

50,426

ND

ND

ND

ND

ND

115/4

ND

ND

ND

Polymeric immunoglobulin receptor OS=Homo sapiens GN=PIGR PE = 1

PIGR_HUMAN

84,429

ND

ND

ND

ND

ND

105/3

109/6

ND

ND

Actin-1 OS = Aedes aegypti GN = ACT-1 PE = 2 SV = 2

ACT1_AEDAE

42,045

ND

ND

ND

ND

ND

ND

490/17

361/20

335/17

Keratin, type II cytoskeletal 6A OS = Rattus norvegicus GN=Krt6a PE = 1 SV = 1

K2C6A_RAT

59,555

ND

ND

ND

ND

ND

ND

331/7

123/3

ND

Ceruloplasmin OS=Homo sapiens GN=CP PE = 1

CERU_HUMAN

122,983

ND

ND

ND

ND

ND

ND

196/6

188/8

124/3

Alpha-enolase OS=Bos taurus GN = ENO1 PE = 1 SV = 4

ENOA_BOVIN

47,639

ND

ND

ND

ND

ND

ND

163/7

171/6

ND

Gelsolin OS=Homo sapiens GN = GSN PE = 1 SV = 1

GELS_HUMAN

86,043

ND

ND

ND

ND

ND

ND

148/6

186/8

122/5

Elongation factor 1-alpha OS=Onchocerca volvulus PE = 2

EF1A_ONCVO

51,090

ND

ND

ND

ND

ND

ND

106/3

ND

ND

Alpha-crystallin B chain OS=Bos taurus GN=CRYAB PE = 1

CRYAB_BOVIN

20,024

ND

ND

ND

ND

ND

ND

ND

140/3

ND

Annexin A1 (Fragment) OS = Gallus gallus GN = ANXA1 PE = 2 SV = 1

ANXA1_CHICK

14,446

ND

ND

ND

ND

ND

ND

ND

121/2

ND