|
Parameter
|
Values
|
|---|
|
Emax (log10 CFU/thigh)
|
3.86
|
|
E0 (log10 CFU/thigh)
|
−4.95
|
|
EC50 (h)
|
9.05
|
|
N
|
1.38
|
|
Dividing AUC0–24/MIC by 24 h for bacteriostatic action
|
0.325
|
|
Dividing AUC0–24/MIC by 24 h for 1-log10 reduction
|
0.4375
|
|
Dividing AUC0–24/MIC by 24 h for 2-log10 reduction
|
0.63
|
|
Dividing AUC0–24/MIC by 24 h for 3-log10 reduction
|
0.95
|
- Emax is △logCFU24 h in the control sample (drug-free); E0 is △logCFU24 hrs in the experimental sample comprising ENR when the maximum potential against bacterial growth was obtained; EC50 represents the PK-PD index for the drug which shows 50% of the highest antibacterial effect; N represents Hill coefficient (demonstrating the steepness of the effect curve obtained from PK-PD index)
