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Table 4 The PK-PD parameter estimates for the dividing AUC0–24/MIC by 24 h to obtain different antibacterial effects

From: Pharmacokinetics and pharmacodynamics of enrofloxacin treatment of Escherichia coli in a murine thigh infection modeling

Parameter

Values

Emax (log10 CFU/thigh)

3.86

E0 (log10 CFU/thigh)

−4.95

EC50 (h)

9.05

N

1.38

Dividing AUC0–24/MIC by 24 h for bacteriostatic action

0.325

Dividing AUC0–24/MIC by 24 h for 1-log10 reduction

0.4375

Dividing AUC0–24/MIC by 24 h for 2-log10 reduction

0.63

Dividing AUC0–24/MIC by 24 h for 3-log10 reduction

0.95

  1. Emax is â–³logCFU24 h in the control sample (drug-free); E0 is â–³logCFU24 hrs in the experimental sample comprising ENR when the maximum potential against bacterial growth was obtained; EC50 represents the PK-PD index for the drug which shows 50% of the highest antibacterial effect; N represents Hill coefficient (demonstrating the steepness of the effect curve obtained from PK-PD index)
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BMC Veterinary Research

ISSN: 1746-6148

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