Skip to main content

Table 3 Clinicopathologic characteristics in canine mammary carcinomas (CMCs) immunophenotypes

From: Vitamin D receptor (VDR) expression in different molecular subtypes of canine mammary carcinoma

Variable Range No. of Luminal A cases (%) No. of Luminal B cases (%) No. of HER2+ cases (%) No. of triple-negative cases (%) P value
VDR expression Positive 4 (19) 3 (27.3) 0 9 (45)  
Negative 17 (81) 8 (72.7) 6 (100) 11 (55) ns
ER expression Positive 18 (85.7) 9 (81.8) 0 0  
Negative 3 (14.3) 2 (18.2) 6 (100) 20 (100) P < 0.001
PR expression Positive 20 (95.2) 10 (90.9) 0 0  
Negative 1 (4.8) 1 (9.1) 6 (100) 20 (100) P < 0.001
HER2 expression Positive 7 (33.3) 4 (36.4) 6 (100) 0  
Negative 14 (66.7) 7 (63.6) 0 20 (100) P = 0.002
Age <10 y 11 (52.4) 6 (54.5) 1 (16.7) 9 (45)  
≥10 y 10 (47.6) 5 (45.5) 5 (83.3) 11 (55) ns
Breed Pure 13 (61.9) 7 (63.6) 3 (50) 8 (40)  
Crossing 8 (38.1) 4 (36.4) 3 (50) 12 (60) ns
No. of Tumours One 5 (23.8) 3 (23.7) 3 (50) 10 (50)  
More 16 (76.2) 8 (72.7) 3 (50) 10 (50) ns
Tumour size (cm)   2.1±0.8 2.3±0.9 3.1±0.4 1.9±0.3 ns
Lymphatic invasion Yes 2 (9.5) 2 (18.2) 2 (33.3) 10 (50)  
No 19 (90.5) 9 (81.8) 4 (66.7) 10 (50)  P = 0.028
Histologic subtype Simple 7 (33.3) 1 (9.1) 5 (83.3) 8 (40)  
Complex 13 (61.9) 4 (36.4) 1 (16.7) 9 (45)  
Mixed 1 (4.8) 6(54.5) 0 3 (15) P = 0.007
Histological grade Grade 1 10 (47.6) 11 (100) 3 (50) 5 (25)  
Grade 2 10 (47.6) 0 0 8 (40)  
Grade 3 1 (4.8) 0 3 (50) 7 (35) P = 0.045
IP   6.1 ± 2.9 22.2 ± 12.0 27.5 ± 18.1 16.7 ± 18.2 ns
  1. ns not significant