Table 3 Clinicopathologic characteristics in canine mammary carcinomas (CMCs) immunophenotypes
From: Vitamin D receptor (VDR) expression in different molecular subtypes of canine mammary carcinoma
Variable | Range | No. of Luminal A cases (%) | No. of Luminal B cases (%) | No. of HER2+ cases (%) | No. of triple-negative cases (%) | P value |
|---|---|---|---|---|---|---|
VDR expression | Positive | 4 (19) | 3 (27.3) | 0 | 9 (45) | |
Negative | 17 (81) | 8 (72.7) | 6 (100) | 11 (55) | ns | |
ER expression | Positive | 18 (85.7) | 9 (81.8) | 0 | 0 | |
Negative | 3 (14.3) | 2 (18.2) | 6 (100) | 20 (100) | P < 0.001 | |
PR expression | Positive | 20 (95.2) | 10 (90.9) | 0 | 0 | |
Negative | 1 (4.8) | 1 (9.1) | 6 (100) | 20 (100) | P < 0.001 | |
HER2 expression | Positive | 7 (33.3) | 4 (36.4) | 6 (100) | 0 | |
Negative | 14 (66.7) | 7 (63.6) | 0 | 20 (100) | P = 0.002 | |
Age | <10 y | 11 (52.4) | 6 (54.5) | 1 (16.7) | 9 (45) | |
≥10 y | 10 (47.6) | 5 (45.5) | 5 (83.3) | 11 (55) | ns | |
Breed | Pure | 13 (61.9) | 7 (63.6) | 3 (50) | 8 (40) | |
Crossing | 8 (38.1) | 4 (36.4) | 3 (50) | 12 (60) | ns | |
No. of Tumours | One | 5 (23.8) | 3 (23.7) | 3 (50) | 10 (50) | |
More | 16 (76.2) | 8 (72.7) | 3 (50) | 10 (50) | ns | |
Tumour size (cm) | 2.1±0.8 | 2.3±0.9 | 3.1±0.4 | 1.9±0.3 | ns | |
Lymphatic invasion | Yes | 2 (9.5) | 2 (18.2) | 2 (33.3) | 10 (50) | |
No | 19 (90.5) | 9 (81.8) | 4 (66.7) | 10 (50) | P = 0.028 | |
Histologic subtype | Simple | 7 (33.3) | 1 (9.1) | 5 (83.3) | 8 (40) | |
Complex | 13 (61.9) | 4 (36.4) | 1 (16.7) | 9 (45) | ||
Mixed | 1 (4.8) | 6(54.5) | 0 | 3 (15) | P = 0.007 | |
Histological grade | Grade 1 | 10 (47.6) | 11 (100) | 3 (50) | 5 (25) | |
Grade 2 | 10 (47.6) | 0 | 0 | 8 (40) | ||
Grade 3 | 1 (4.8) | 0 | 3 (50) | 7 (35) | P = 0.045 | |
IP | 6.1 ± 2.9 | 22.2 ± 12.0 | 27.5 ± 18.1 | 16.7 ± 18.2 | ns |