Table 2 Variations affecting the interaction with RAD51
From: Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Type of variation | Name/designation | Localization | Effect | Studied material | Reference |
|---|---|---|---|---|---|
1 polymorphism | 1425P allele | BRC3–4 | Reduced binding strength with RAD51 | Blood samples of tumor-free dogs | [53] |
19 SNPs | amongst others, c.2383A > C (T1425P) | BRC1-BRC8, C-terminus region (exon 11) | Affects RAD51 binding strength | Tissue samples from canine mammary tumors | [54] |
4 substitutions | S1078 W, A1108G, T1425P, T1559P | BRC3 | Affects RAD51 binding strength | In silico analysis derived from mammary tumors | [54] |