Fig. 1
From: Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy
Simplified steps leading to BRCA2-RAD51 interaction after a break, depending on the BRCA2 mutation status. After formation of the DSB, DNA resection is dependent on BRCA1. BRCA2 then localizes RAD51 to the DNA, and RAD51 is loaded onto RPA-coated DNA to invade the DNA double helix. When the BRCA2 gene is mutated, and therefore the BRCA2 protein deficient, RAD51 cannot be efficiently localized onto DNA (figure based on: Wooster R. et al., 1995; Prakash R. et al., 2015; Shailani A. et al., 2018 [25, 27, 28])