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Salmonella enterica subspecies houtenae as an opportunistic pathogen in a case of meningoencephalomyelitis and bacteriuria in a dog

Abstract

Background

We report the first case of canine Salmonella meningoencephalomyelitis and second case of canine Salmonella bacteriuria, as well as the first reported case of Salmonella enterica subspecies houtenae in a dog.

Case presentation

Immunosuppressive treatment in a dog for a relapse of steroid-responsive meningitis and arteritis (SRMA) allowed for the opportunistic establishment of a bacteremia with Salmonella enterica subsp. houtenae, ultimately causing meningoencephalomyelitis and subclinical bacteriuria. The bacterial infections were treated with a four-month course of amoxicillin; clinical treatment success was determined by serial negative urine cultures and lack of clinical signs correlated to the meningoencephalomyelitis.

Conclusions

Both the bacteriuria and meningoencephalomyelitis represented opportunistic infections in a dog immunosuppressed for SRMA. The clinical course of this infectious meningoencephalitis emphasizes the importance of differentiating relapse of initial disease from opportunistic infection occurring in a compromised central nervous system. The novel Salmonella species identified in this case acts as a reminder that infectious disease diagnostics should not be curbed by anecdotal prediction of routine pathogenic suspects.

Background

The genus Salmonella is comprised of two species: S. bongori and S. enterica. Salmonella enterica is further subdivided into 6 subspecies: enterica (I), salamae (II), arizonae (IIIa), diarizonae (IIIb), houtenae (IV), and indica (VI). Of these subspecies, subsp. enterica is the most common cause of disease in mammals and contains 2600 serovars that can be divided into typhoidal and non-typhoidal Salmonella (NTS) serovars. Most commonly, NTS infections in humans and dogs induce gastroenteritis.

Salmonella can be found in the fecal samples of healthy, non-diarrheic dogs. In one study conducted across 11 labs in the United States, almost 2500 fecal samples of dogs with and without diarrhea had an overall Salmonella prevalence of 3% (~ 50% of which were non-diarrheic) [1]. Additionally, there is marked variety of Salmonella spp. isolated from canine gastrointestinal flora; one study reported that 5.6% of healthy dogs were found to be Salmonella-positive based on fecal culture, with 35 different Salmonella isolates belonging to six serovars of subsp. enterica [2].

Subspecies salamae, arizonae, diarizonae, houtenae, and indica have been recovered from a wide variety of animal species, most commonly from reptiles. Salmonella enterica subsp. houtenae was originally isolated from a cockatiel in 1978 and has been recovered from a variety of animals including mammals, birds, reptiles, and amphibians [3,4,5,6,7,8,9,10,11]. Interestingly opossums were also reported to carry the organism asymptomatically in their the biliary tract [10]. Infections in veterinary patients include reports of osteomyelitis in an adult female Taylor’s cantil (Agkistrodon bilineatus taylori)) and ovarian bacterial granulomas in a Duvaucel’s gecko (Hoplodactylus duvaucelii) [12, 13]. Although infrequently isolated from humans, S. enterica subsp. houtenae has been reported in association with meningitis or brain abscesses primarily in children or immunocompromised adults [14,15,16,17,18].

Case presentation

In 2015, a 1-year-old female spayed Boxer was presented to the Texas A&M Veterinary Medical Teaching Hospital for neck pain. The dog was diagnosed with SRMA on the basis of consistent MRI and CSF analysis findings paired with negative infectious disease testing. Following 6 months of steroid therapy, she achieved complete clinical resolution and steroids were discontinued. Three and a half years later, the dog was presented for lumbar pain. MRI and CT of the lumbar spine were performed, revealing no abnormalities, and CSF analysis revealed a mild to moderate neutrophilic pleocytosis (58% nondegenerate neutrophils, 31% small mononuclear cells). No infectious disease testing was performed at this time. The dog was presumptively diagnosed with relapse of SRMA and treated with steroid monotherapy (1.6 mg/kg/day). Clinical response was incomplete, so prednisone was increased (2.3 mg/kg/day) and azathioprine was added (2 mg/kg/day × 14 days, then 2 mg/kg/EOD). Clinical signs subsequently resolved.

Two months after beginning immunosuppressive treatment, the dog was presented for an acute onset of seizure activity, low head carriage, and abnormal behavior. On examination, the dog was febrile, ambulatory tetraparetic with generalized proprioceptive deficits, and diffusely painful on paraspinal palpation. Quantitative aerobic culture of urine obtained via cystocentesis yielded greater than 100,000 CFU/mL of a Salmonella enterica. Bacterial identification was confirmed using matrix-assisted, laser desorption and time of flight (MALDI-TOF) mass spectrometry and PCR to detect the spaQ gene [5, 19, 20]. Brain MRI revealed multifocal T2 and FLAIR hyperintensities of the piriform and olfactory lobes with no abnormal contrast enhancement. Cerebrospinal fluid analysis showed marked neutrophilic pleocytosis (89% non-degenerate neutrophils, 10% large mononuclear cells) with rare intracellular rods, measuring approximately 1 μm × 3 μm. These bacteria were confirmed to be Salmonella enterica on culture of CSF [19]. Susceptibility data is provided in ‘Additional file’ in the supplemental information section. Genome sequencing of the bacterial isolates from urine and CSF identified the isolates as Salmonella enterica subsp. houtenae [19].

The dog’s urinary tract infection and encephalomyelitis were initially treated with a combination therapy of enrofloxacin (12.3 mg/kg/day) and trimethoprim sulfamethoxazole (13 mg/kg q12hr), as well as prednisone (0.9 mg/kg/day), levetiracetam, and analgesics. A gradual taper of azathioprine was also initiated to avoid a rebound hyperimmune response. Approximately 1 month into treatment, antibiotics were inadvertently discontinued due to marked clinical improvement and repeat urine culture performed 2 weeks later showed growth of a Salmonella species despite a normal neurologic exam. A three-month taper of prednisone was initiated. Amoxicillin was prescribed (13 mg/kg q8hr), resulting in a negative urine culture 3 weeks later.

Amoxicillin was again inadvertently discontinued prematurely due to clinical improvement, resulting in a positive urine culture approximately 4 months after diagnosis; amoxicillin was restarted again after this positive urine culture. Amoxicillin was then continued consistently for an additional 4 months and urine cultures at the 1-month and 4-month time points were both negative. Amoxicillin was discontinued after this 4-month negative urine culture. The dog remained free of any clinical signs during this 4-month period on amoxicillin.

Following discontinuation of antibiotics, it was the authors’ clinical discretion to not perform repeat cultures of urine, CSF, or blood, or to repeat advanced imaging unless clinical signs recurred; treating an incidental discovery of recrudescence of Salmonella species in urine or blood in an otherwise non-clinical and immunocompetent patient would not be a judicious practice of antibiotic stewardship, especially given the emerging concern of antibiotic resistance in Salmonella species.

Additionally, the dog had not had any known seizure activity since the initial seizure (noted at the time of the meningoencephalitis diagnosis), so a 6-week taper of levetiracetam was initiated once the dog was 6 months seizure-free; the dog has had no known seizure activity since.

Discussion and conclusion

Extra-intestinal non-typhoidal Salmonella (NTS) infections are rare in humans. Bacteremia is reported to occur in 5–10% of humans who are infected with NTS, and immunosuppression and young age (< 1 yr) are risk factors for severe clinical outcomes [21, 22]. NTS infections of the urinary tract are uncommon. In a cohort single-center study that reviewed all cases of NTS urinary tract infections, 27% of patients had isolated symptomatic NTS urinary tract infection without gastroenteritis or Salmonella isolated from a fecal sample. These individuals were found to have a higher rate of underlying lower urinary tract malignancies, as well as higher rates of diabetes and underlying immunosuppressive states [23].

Here, we report the second case of Salmonella bacteriuria in a dog. In the previous report, a dog undergoing immunosuppressive treatment for IMPA had non-clinical bacteriuria, and Salmonella enterica serovar Typhimurium was isolated from the dog’s urine culture [24].

Central nervous system infections due to Salmonella spp. are uncommon in humans and have not been previously reported in dogs. In humans, structural brain disease and systemic immunocompromise have been associated with intracranial Salmonella infection [25, 26]. In children, meningitis is of particularly high risk in infants less than 6 months of age [22]. While meningitis is the most common presentation for Salmonella CNS infections, a few case reports have identified NTS as the etiologic agent for acute transverse myelitis [27, 28]. No serotype has been found to have a greater predilection for the CNS compared to others [29], although Salmonella Enteridis Group D1 was reported to be the most common agent in one report of Samonella meningitis in children [30].

The serovar isolated in this case Salmonella enterica subsp. houtenae is a novel serotype in dogs. This serotype is commonly identified in reptiles and amphibians and more than 90% of reptiles are asymptomatic carriers, contaminating their environment via fecal shedding [18]. In this case, geckos, lizards, and turtles are commonly found in the dog’s yard and have access to the dog’s outdoor water bowl. A limitation of this case management is the absence of cultures of various samples from the dog’s environment to support this hypothesis of source of infection. However, it is the authors’ opinion that given the 3-month time course that elapsed between initial culture diagnosis of a Salmonella species and the subsequent genome identification of S. houtenae, there would be low utility of post-hoc collection and culture of samples.

Of the 51 publications of clinical infection with S. houtenae in people, 5 are case reports of meningitis or brain abscess; 4 affected patients were children and 1 was a patient with HIV [14,15,16,17,18]. In all of these cases, CNS infection was recognized without any preluding or concomitant gastrointestinal signs, similar to the dog in this case report.

There is very limited evidence to guide treatment of NTS gastroenteritis, bacteremia, and complicated infections, such as meningitis and osteomyelitis. Given that NTS resides intracellularly within phagocytes after invading the gastrointestinal epithelium, antibiotics with intracellular penetration are often first line [22]. Amoxicillin/ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, azithromycin, and third-generation cephalosporins are often recommended; aminoglycosides have poor clinical efficacy despite proven in vitro activity [22, 29]. There are also no universally-accepted guidelines for the duration for which to treat NTS infection, although a minimum of 4–6 weeks is repeatedly cited [22, 26, 29, 31]. Relapses, if they occur, are thought to most likely be recrudescence rather than re-infection, due to the intracellular persistence of NTS and difficulty achieving adequate and prolonged macrophage penetration [22].

Increasing antimicrobial resistance of Salmonella is an emerging concern, especially resistance to fluoroquinolones. Resistance rates varies with different serotypes; S. Enteritidis is reported to have shown less resistance than other serovars whereas S. Typhimurium definitive phage type (DT) 104 has become multidrug-resistant [21]. The authors acknowledge that retrospectively, a more judicious choice regarding initial antibiotic therapy could have been made in this particular case.

It is unclear if the lumbar pain and neutrophilic pleocytosis that occurred 3.5 years after initial SRMA diagnosis was a SRMA relapse or the first manifestation of Salmonella meningomyelitis, although timing suggests the former. In two studies of the clinical course of SRMA, all dogs had cervical pain on presentation, with thoracolumbar being a concurrent clinical sign in 15 and 34% of dogs; isolated lumbar pain in the absence of cervical pain was not reported in these two populations [32, 33]. Description of clinical signs associated with relapses commonly report “recurrence of previous signs,” cervical pain, lethargy, neurological deficits (paresis, ataxia), and fever [11, 33,34,35]. Though first relapses have been reported up to 2176 days, most occur earlier [11, 32].

This case highlights a novel opportunistic infection in an immunocompromised dog. Culture of CSF and urine as well as blood cultures should be considered in any immunocompromised animal with a compromised barrier system (e.g. dog with meningitis) presenting with potential ‘relapsing’ clinical signs attributable to their initial disease. Although Salmonella should be considered as a cause of opportunistic infection, we do not recommend fecal culture as a component of the diagnostic work-up given that Salmonella can be a found in fecal samples of healthy dogs.

Availability of data and materials

The datasets generated and/or analyzed during the current study are available in GenBank. The Genbank accession numbers are JAAAGG000000000 (TAMU36, August 2019 urine isolate), JAAAGF000000000 (TAMU38, August 2019 CSF isolate), and JAAAGE000000000 (TAMU76, October 2019 urine isolate) at BioProject accession number PRJNA600881 [https://www.ncbi.nlm.nih.gov/bioproject/PRJNA600881]. The raw sequence reads are available under the SRA accession numbers SRR10876206 [https://www.ncbi.nlm.nih.gov/sra/SRR10876206], SRR10876207 [https://www.ncbi.nlm.nih.gov/sra/SRR10876207], and SRR10876208 [https://www.ncbi.nlm.nih.gov/sra/SRR10876208].

Abbreviations

AIDS:

Acquired immunodeficiency syndrome

CNS:

Central nervous system

CSF:

Cerebrospinal fluid

CT:

Computed tomography

FLAIR:

Fluid-attenuated inversion recovery

HIV:

Human immunodeficiency virus

IMPA:

Immune-mediated polyarthritis

MRI:

Magnetic resonance imaging

SRMA:

Steroid-responsive meningitis and arteritis

T2:

Transverse relaxation time

NTS:

Non-typhoidal Salmonella

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Contributions

MA and BB managed the clinical case. SL and MK performed the genome sequencing. MA, BB, SL all contributed to the writing of this report. All authors have read and approved the manuscript.

Corresponding author

Correspondence to Melissa N. Andruzzi.

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Consent was obtained from the owner of the dog for publication of this case report; written consent form available upon request.

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Supplementary Information

Additional file 1.

Susceptibility data of Salmonella isolates. This additional file presents the susceptibility data for the Salmonella houtenae at the various timepoints along the dog’s clinical course, both from urine and CSF. These isolate interpretations are based upon E. coli breakpoints for dogs when possible and based upon human data when there are no known breakpoints.

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Andruzzi, M.N., Krath, M.L., Lawhon, S.D. et al. Salmonella enterica subspecies houtenae as an opportunistic pathogen in a case of meningoencephalomyelitis and bacteriuria in a dog. BMC Vet Res 16, 437 (2020). https://doi.org/10.1186/s12917-020-02652-5

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Keywords

  • SRMA (steroid-responsive meningitis arteritis)
  • Salmonella enterica subspecies houtenae
  • Meningoencephalitis
  • Bacteriuria
  • Opportunistic infection