Table 1 Proteins chosen for investigation of altered proteins in tylosin-resistant S. xylosus
Protein ID | Gene name | Proteins | Unique Peptides | Average iTRAQ ratio | P-value | Main function |
|---|---|---|---|---|---|---|
A0A068E6D9 | rplW | 1 | 9 | 1.389 | 0.034 | RPL23 is of approximately 70 proteins associated with rRNA in the large and small subunits of the ribosome, which is related to multidrug-resistant gastric cancer cell line. |
C6ZDJ2 | infB | 1 | 1 | 1.366 | 0.044 | Initiation factor (IF) 2 controls the fidelity of translation initiation,and domain III of IF2 plays a pivotal, allosteric, role in IF2 activation, which can be targeted for the development of novel antibiotics. |
A0A068E9E8 | aldA-1 | 2 | 1 | 1.647 | 0.001 | The aldehyde dehydrigenases is a kind of metabolize aldehydes, thereby can mitigate oxidative stress. |
A060MCA0 | trxA | 3 | 6 | 0.657 | 0.045 | Thioredoxin play important roles in maintaining an intracellular reducing environment and combating oxidative stress in variety of organisms, including gram-positive and gram-negative bacteria. |
A0A068E7D1 | katA | 4 | 16 | 0.528 | 0.002 | The activity of catalase is used to estimate the contribution of antioxidant systems to bacterial response to oxidative stress. |
A7KJI7 | gros | 1 | 8 | 0.636 | 0.03 | The chaperones played a major role in bacterial survival under conditions of stressc. |