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Table 6 pH, HCO3-, sBE plasma glucose, −lactate and –triglycerides

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

 

Baseline

Measurement 1

Measurement 2

Measurement 3

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

pH

Isoflurane

7.38 ± 0.04A

7.35 ± 0.04

7.37 ± 0.05

7.38 ± 0.02AB

Sevoflurane

7.39 ± 0.02AB

7.35 ± 0.02

7.36 ± 0.02

7.39 ± 0.04A

Propofol

7.41 ± 0.02B

7.33 ± 0.03*

7.33 ± 0.04*

7.30 ± 0.04*B

Alfaxalone

7.39 ± 0.05AB

7.34 ± 0.03

7.35 ± 0.03

7.35 ± 0.03AB

HCO3−

[mmol L− 1]

Isoflurane

21.01 ± 1.73A

20.44 ± 1.74AB

20.00 ± 1.37AB

21.00 ± 1.57AB

Sevoflurane

22.22 ± 1.46AB

20.32 ± 1.09*A

20.86 ± 0.99AB

20.66 ± 1.24AB

Propofol

22.01 ± 1.87B

20.10 ± 1.31*A

19.67 ± 1.34*A

18.58 ± 1.11*A

Alfaxalone

21.71 ± 1.59AB

21.73 ± 1.07B

22.00 ± 1.04B

21.94 ± 0.92B

sBE

[mmol L− 1]

Isoflurane

−2.77 ± 1.31A

−4.27 ± 1.95AB

−4.38 ± 1.85AB

−3.30 ± 1.59AB

Sevoflurane

−2.02 ± 1.54AB

−4.30 ± 1.08*AB

−3.70 ± 1.09AB

−3.56 ± 1.16*B

Propofol

− 1.84 ± 1.70B

− 4.86 ± 1.46*A

−5.27 ± 1.55*A

−6.67 ± 1.41*A

Alfaxalone

−2.5 ± 1.33AB

− 3.08 ± 1.06B

−2.78 ± 1.05B

−2.85 ± 0.98B

Na+

[mmol L− 1]

Isoflurane

148.2 ± 1.48

147.7 ± 1A

146.8 ± 1*B

147.25 ± 1.2AB

Sevoflurane

147.9 ± 1.66

148.1 ± 1.8

146.2 ± 2.2*A

146.2 ± 1.6*A

Propofol

147.2 ± 1.48

147.33 ± 1.7A

147.6 ± 1.8A

148.89 ± 1.6*

Alfaxalone

147.67 ± 1.66

149 ± 1.1*

150.7 ± 3.1*

149.8 ± 0.9*

Glucose

[mmol L− 1]

Isoflurane

5.29 ± 0.25

5.84 ± 0.61B

6.13 ± 0.65A

6.00 ± 0.49*ABC

Sevoflurane

5.29 ± 0.37

5.19 ± 0.21AC

5.56 ± 0.40A

5.59 ± 0.42A

Propofol

5.20 ± 0.28

4.98 ± 0.38A

4.97 ± 0.27

4.92 ± 0.30B

Alfaxalone

5.65 ± 0.63

5.83 ± 0.49BC

6.17 ± 0.93A

6.31 ± 0.66C

Lactate

[mmol L− 1]

Isoflurane

1.06 ± 0.40A

2.03 ± 0.94*A

2.10 ± 0.69*A

1.97 ± 0.78

Sevoflurane

1.01 ± 0.30AB

1.61 ± 0.56AB

1.89 ± 0.74*AB

1.58 ± 0.77

Propofol

1.01 ± 0.33B

1.12 ± 0.34B

1.31 ± 0.55AB

1.41 ± 0.23

Alfaxalone

0.95 ± 0.49AB

0.86 ± 0.83B

1.03 ± 0.64B

1.14 ± 0.57

Triglycerides

[mmol L− 1]

Isoflurane

0.53 ± 0.17A

0.36 ± 0.13*AB

0.29 ± 0.13*A

0.36 ± 0.24AB

Sevoflurane

0.53 ± 0.14AB

0.36 ± 0.14A

0.29 ± 0.11*A

0.27 ± 0.09*

Propofol

0.55 ± 0.12B

2.82 ± 1.02*

2.97 ± 1.21*

3.46 ± 1.07*A

Alfaxalone

0.59 ± 0.16AB

0.22 ± 0.06*B

0.19 ± 0.07*A

0.20 ± 0.06*B

  1. Mean ± SD of the results of blood gas analysis (pH, HCO3- [mmol L-1], sBE [mmol L-1]) and plasma glucose [mmol L-1], −lactate [mmol L-1] and -triglycerides [mmol L-1] before anaesthesia, after measurement period 1, 2 and 3; * p < 0.05 compared to baseline within one Treatment, Different alphabetical superscripts differ in between treatments at one measurementpoint (p < 0.05)