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Table 6 pH, HCO3-, sBE plasma glucose, −lactate and –triglycerides

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

  Baseline Measurement 1 Measurement 2 Measurement 3
Mean ± SD Mean ± SD Mean ± SD Mean ± SD
pH Isoflurane 7.38 ± 0.04A 7.35 ± 0.04 7.37 ± 0.05 7.38 ± 0.02AB
Sevoflurane 7.39 ± 0.02AB 7.35 ± 0.02 7.36 ± 0.02 7.39 ± 0.04A
Propofol 7.41 ± 0.02B 7.33 ± 0.03* 7.33 ± 0.04* 7.30 ± 0.04*B
Alfaxalone 7.39 ± 0.05AB 7.34 ± 0.03 7.35 ± 0.03 7.35 ± 0.03AB
HCO3
[mmol L− 1]
Isoflurane 21.01 ± 1.73A 20.44 ± 1.74AB 20.00 ± 1.37AB 21.00 ± 1.57AB
Sevoflurane 22.22 ± 1.46AB 20.32 ± 1.09*A 20.86 ± 0.99AB 20.66 ± 1.24AB
Propofol 22.01 ± 1.87B 20.10 ± 1.31*A 19.67 ± 1.34*A 18.58 ± 1.11*A
Alfaxalone 21.71 ± 1.59AB 21.73 ± 1.07B 22.00 ± 1.04B 21.94 ± 0.92B
sBE
[mmol L− 1]
Isoflurane −2.77 ± 1.31A −4.27 ± 1.95AB −4.38 ± 1.85AB −3.30 ± 1.59AB
Sevoflurane −2.02 ± 1.54AB −4.30 ± 1.08*AB −3.70 ± 1.09AB −3.56 ± 1.16*B
Propofol − 1.84 ± 1.70B − 4.86 ± 1.46*A −5.27 ± 1.55*A −6.67 ± 1.41*A
Alfaxalone −2.5 ± 1.33AB − 3.08 ± 1.06B −2.78 ± 1.05B −2.85 ± 0.98B
Na+
[mmol L− 1]
Isoflurane 148.2 ± 1.48 147.7 ± 1A 146.8 ± 1*B 147.25 ± 1.2AB
Sevoflurane 147.9 ± 1.66 148.1 ± 1.8 146.2 ± 2.2*A 146.2 ± 1.6*A
Propofol 147.2 ± 1.48 147.33 ± 1.7A 147.6 ± 1.8A 148.89 ± 1.6*
Alfaxalone 147.67 ± 1.66 149 ± 1.1* 150.7 ± 3.1* 149.8 ± 0.9*
Glucose
[mmol L− 1]
Isoflurane 5.29 ± 0.25 5.84 ± 0.61B 6.13 ± 0.65A 6.00 ± 0.49*ABC
Sevoflurane 5.29 ± 0.37 5.19 ± 0.21AC 5.56 ± 0.40A 5.59 ± 0.42A
Propofol 5.20 ± 0.28 4.98 ± 0.38A 4.97 ± 0.27 4.92 ± 0.30B
Alfaxalone 5.65 ± 0.63 5.83 ± 0.49BC 6.17 ± 0.93A 6.31 ± 0.66C
Lactate
[mmol L− 1]
Isoflurane 1.06 ± 0.40A 2.03 ± 0.94*A 2.10 ± 0.69*A 1.97 ± 0.78
Sevoflurane 1.01 ± 0.30AB 1.61 ± 0.56AB 1.89 ± 0.74*AB 1.58 ± 0.77
Propofol 1.01 ± 0.33B 1.12 ± 0.34B 1.31 ± 0.55AB 1.41 ± 0.23
Alfaxalone 0.95 ± 0.49AB 0.86 ± 0.83B 1.03 ± 0.64B 1.14 ± 0.57
Triglycerides
[mmol L− 1]
Isoflurane 0.53 ± 0.17A 0.36 ± 0.13*AB 0.29 ± 0.13*A 0.36 ± 0.24AB
Sevoflurane 0.53 ± 0.14AB 0.36 ± 0.14A 0.29 ± 0.11*A 0.27 ± 0.09*
Propofol 0.55 ± 0.12B 2.82 ± 1.02* 2.97 ± 1.21* 3.46 ± 1.07*A
Alfaxalone 0.59 ± 0.16AB 0.22 ± 0.06*B 0.19 ± 0.07*A 0.20 ± 0.06*B
  1. Mean ± SD of the results of blood gas analysis (pH, HCO3- [mmol L-1], sBE [mmol L-1]) and plasma glucose [mmol L-1], −lactate [mmol L-1] and -triglycerides [mmol L-1] before anaesthesia, after measurement period 1, 2 and 3; * p < 0.05 compared to baseline within one Treatment, Different alphabetical superscripts differ in between treatments at one measurementpoint (p < 0.05)