Han X, Gross RW. Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res. 2003;44(6):1071–9.
Article
CAS
PubMed
Google Scholar
Hu C, van der Heijden R, Wang M, van der Greef J, Hankemeier T, Xu G. Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877(26):2836–46.
Article
CAS
PubMed
Google Scholar
Wenk MR. The emerging field of lipidomics. Nat Rev Drug Discov. 2005;4(7):594–610.
Article
CAS
PubMed
Google Scholar
Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res. 2009;48(1):1–26.
Article
CAS
PubMed
Google Scholar
Watson AD. Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006;47(10):2101–11.
Article
CAS
PubMed
Google Scholar
Arnold AP. Promoting the understanding of sex differences to enhance equity and excellence in biomedical science. Biol Sex Differ. 2010;1(1):1. -6410-1-1
Article
PubMed
PubMed Central
Google Scholar
Taylor KC, Carty CL, Dumitrescu L, Buzkova P, Cole SA, Hindorff L, Schumacher FR, Wilkens LR, Shohet RV, Quibrera PM, Johnson KC, Henderson BE, Haessler J, Franceschini N, Eaton CB, Duggan DJ, Cochran B, Cheng I, Carlson CS, Brown-Gentry K, Anderson G, Ambite JL, Haiman C, Le Marchand L, Kooperberg C, Crawford DC, Buyske S, North KE, Fornage M, PAGE Study. Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study. BMC Genet. 2013;14:33-2156-14-33.
Article
Google Scholar
Gardner CD, Winkleby MA, Fortmann SP. Population frequency distribution of non-high-density lipoprotein cholesterol (third National Health and nutrition examination survey [NHANES III], 1988-1994). Am J Cardiol. 2000;86(3):299–304.
Article
CAS
PubMed
Google Scholar
Gostynski M, Gutzwiller F, Kuulasmaa K, Doring A, Ferrario M, Grafnetter D, Pajak A, WHO MONICA Project. Analysis of the relationship between total cholesterol, age, body mass index among males and females in the WHO MONICA project. Int J Obes Relat Metab Disord. 2004;28(8):1082–90.
Article
CAS
PubMed
Google Scholar
Regitz-Zagrosek V, Lehmkuhl E, Mahmoodzadeh S. Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med. 2007;4 Suppl B:S162–77.
Article
PubMed
Google Scholar
Williams CM. Lipid metabolism in women. Proc Nutr Soc. 2004;63(1):153–60.
Article
CAS
PubMed
Google Scholar
Ostwald R, Bouchard P, Miljanich P, Lyman RL. Influence of sex and gonadal hormones on rat-liver and carcass lipids during the development of an essential fatty acid deficiency. Biochem J. 1965;97(2):485–99.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lyman RL, Tinoco J, Bouchard P, Sheehan G, Ostwald R, Miljanich P. Sex differences in the metabolism of phosphatidyl cholines in rat liver. Biochim Biophys Acta. 1967;137(1):107–14.
Article
CAS
PubMed
Google Scholar
Lyman RL, Hopkins SM, Sheehan G, Tinoco J. Effects of estradiol and testosterone on the incorporation and distribution of [me-14C]methionine methyl in rat liver lecithins. Biochim Biophys Acta. 1968;152(1):197–207.
Article
CAS
PubMed
Google Scholar
Young DL. Estradiol- and testosterone-induced alterations in phosphatidylcholine and triglyceride synthesis in hepatic endoplasmic reticulum. J Lipid Res. 1971;12(5):590–5.
CAS
PubMed
Google Scholar
Carroll MD, Lacher DA, Sorlie PD, Cleeman JI, Gordon DJ, Wolz M, Grundy SM, Johnson CL. Trends in serum lipids and lipoproteins of adults, 1960-2002. JAMA. 2005;294(14):1773–81.
Article
CAS
PubMed
Google Scholar
Mittendorfer B. Sexual dimorphism in human lipid metabolism. J Nutr. 2005;135(4):681–6.
CAS
PubMed
Google Scholar
Burdge GC, Slater-Jefferies JL, Grant RA, Chung WS, West AL, Lillycrop KA, Hanson MA, Calder PC. Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats. Prostaglandins Leukot Essent Fatty Acids. 2008;78(1):73–9.
Article
CAS
PubMed
Google Scholar
Extier A, Langelier B, Perruchot MH, Guesnet P, Van Veldhoven PP, Lavialle M, Alessandri JM. Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion. J Nutr Biochem. 2010;21(3):180–7.
Article
CAS
PubMed
Google Scholar
Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. The polyunsaturated fatty acid composition of hepatic and plasma lipids differ by both sex and dietary fat intake in rats. J Nutr. 2010;140(2):245–50.
Article
CAS
PubMed
Google Scholar
Bakewell L, Burdge GC, Calder PC. Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. Br J Nutr. 2006;96(1):93–9.
Article
CAS
PubMed
Google Scholar
Giltay EJ, Gooren LJ, Toorians AW, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80(5):1167–74.
CAS
PubMed
Google Scholar
Sprecher H. The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2002;67(2-3):79–83.
Article
CAS
PubMed
Google Scholar
Brenner RR. Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. Prostaglandins Leukot Essent Fatty Acids. 2003;68(2):151–62.
Article
CAS
PubMed
Google Scholar
Burdge GC, Calder PC. Dietary alpha-linolenic acid and health-related outcomes: a metabolic perspective. Nutr Res Rev. 2006;19(1):26–52.
Article
CAS
PubMed
Google Scholar
Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88(4):411–20.
Article
CAS
PubMed
Google Scholar
Pawlosky R, Hibbeln J, Lin Y, Salem N Jr. N-3 fatty acid metabolism in women. Br J Nutr. 2003;90(5):993–4. discussion 994-5
Article
CAS
PubMed
Google Scholar
Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 2008;149(6):3167–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oztekin E, Tiftik AM, Baltaci AK, Mogulkoc R. Lipid peroxidation in liver tissue of ovariectomized and pinealectomized rats: effect of estradiol and progesterone supplementation. Cell Biochem Funct. 2007;25(4):401–5.
Article
CAS
PubMed
Google Scholar
Wang X, Magkos F, Mittendorfer B. Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones. J Clin Endocrinol Metab. 2011;96(4):885–93.
Article
CAS
PubMed
PubMed Central
Google Scholar
Magkos F, Patterson BW, Mohammed BS, Klein S, Mittendorfer B. Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab. 2007;92(4):1311–8.
Article
CAS
PubMed
Google Scholar
Snyder SP, Kingston RS, Wenger DA. Niemann-pick disease. Sphingomyelinosis of Siamese cats. Am J Pathol. 1982;108(2):252–4.
CAS
PubMed
PubMed Central
Google Scholar
Watson TDG, Barrie J. Lipoprotein metabolism and hyperlipidemia in the dog and cat: a review. J Small Anim Pract. 1993;34:479–87.
Article
Google Scholar
Armstrong PJ, Blanchard G. Hepatic lipidosis in cats. Vet Clin North Am Small Anim Pract. 2009;39(3):599–616.
Article
PubMed
Google Scholar
Center SA. Feline hepatic lipidosis. Vet Clin North Am Small Anim Pract. 2005;35(1):225–69.
Article
PubMed
Google Scholar
Verbrugghe A, Bakovic M. Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis. Nutrients. 2013;5(7):2811–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Trevizan L, de Mello KA, Brenna JT, Lawrence P, Waldron MK, Bauer JE. Maintenance of arachidonic acid and evidence of Delta5 desaturation in cats fed gamma-linolenic and linoleic acid enriched diets. Lipids. 2012;47(4):413–23.
Article
CAS
PubMed
Google Scholar
Pawlosky R, Barnes A, Salem N Jr. Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. J Lipid Res. 1994;35(11):2032–40.
CAS
PubMed
Google Scholar
Center SA, Crawford MA, Guida L, Erb HN, King J. A retrospective study of 77 cats with severe hepatic lipidosis: 1975-1990. J Vet Intern Med. 1993;7(6):349–59.
Article
CAS
PubMed
Google Scholar
Valtolina C, Vaandrager AB, Favier RP, Robben JH, Tuohetahuntila M, Kummeling A, Jeusette I, Rothuizen J. No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats. BMC Vet Res. 2015;11:280-015-0591-6.
Article
Google Scholar
Testerink N, Ajat M, Houweling M, Brouwers JF, Pully VV, van Manen HJ, Otto C, Helms JB, Vaandrager AB. Replacement of retinyl esters by polyunsaturated triacylglycerol species in lipid droplets of hepatic stellate cells during activation. PLoS One. 2012;7(4):e34945.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M. The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species. J Biol Chem. 2007;282(39):28362–72.
Article
CAS
PubMed
Google Scholar
Butterwick RF, McConnell M, Markwell PJ, Watson TD. Influence of age and sex on plasma lipid and lipoprotein concentrations and associated enzyme activities in cats. Am J Vet Res. 2001;62(3):331–6.
Article
CAS
PubMed
Google Scholar
Pazak HE, Bartges JW, Cornelius LC, Scott MA, Gross K, Huber TL. Characterization of serum lipoprotein profiles of healthy, adult cats and idiopathic feline hepatic lipidosis patients. J Nutr. 1998;128(12 Suppl):2747S–50S.
CAS
PubMed
Google Scholar
Matthan NR, Jalbert SM, Barrett PH, Dolnikowski GG, Schaefer EJ, Lichtenstein AH. Gender-specific differences in the kinetics of nonfasting TRL, IDL, and LDL apolipoprotein B-100 in men and premenopausal women. Arterioscler Thromb Vasc Biol. 2008;28(10):1838–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nikkila EA, Kekki M. Polymorphism of plasma triglyceride kinetics in normal human adult subjects. Acta Med Scand. 1971;190(1-2):49–59.
CAS
PubMed
Google Scholar
Olefsky J, Farquhar JW, Reaven GM. Sex difference in the kinetics of triglyceride metabolism in normal and hypertriglyceridaemic human subjects. Eur J Clin Investig. 1974;4(2):121–7.
Article
CAS
Google Scholar
Watts GF, Moroz P, Barrett PH. Kinetics of very-low-density lipoprotein apolipoprotein B-100 in normolipidemic subjects: pooled analysis of stable-isotope studies. Metabolism. 2000;49(9):1204–10.
Article
CAS
PubMed
Google Scholar
Hall JA, Barstad LA, Connor WE. Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. J Vet Intern Med. 1997;11(4):238–42.
Article
CAS
PubMed
Google Scholar
Brown B, Mauldin GE, Armstrong J, Moroff SD, Mauldin GN. Metabolic and hormonal alterations in cats with hepatic lipidosis. J Vet Intern Med. 2000;14(1):20–6.
Article
CAS
PubMed
Google Scholar
Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology. 2008;134(2):424–31.
Article
CAS
PubMed
Google Scholar
Giltay EJ, Duschek EJ, Katan MB, Zock PL, Neele SJ, Netelenbos JC. Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol. 2004;182(3):399–408.
Article
CAS
PubMed
Google Scholar
Hoene M, Li J, Haring HU, Weigert C, Xu G, Lehmann R. The lipid profile of brown adipose tissue is sex-specific in mice. Biochim Biophys Acta. 2014;1842(10):1563–70.
Article
PubMed
Google Scholar
Rivers JP, Sinclair AJ, Craqford MA. Inability of the cat to desaturate essential fatty acids. Nature. 1975;258(5531):171–3.
Article
CAS
PubMed
Google Scholar
Mahfouz MM, Smith TL, Kummerow FA. Effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat-liver microsomes. Lipids. 1984;19(3):214–22.
Article
CAS
PubMed
Google Scholar
Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2001;281(6):G1333–9.
CAS
PubMed
Google Scholar
Clarke SD. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr. 2001;131(4):1129–32.
CAS
PubMed
Google Scholar
Videla LA, Rodrigo R, Araya J, Poniachik J. Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease. Free Radic Biol Med. 2004;37(9):1499–507.
Article
CAS
PubMed
Google Scholar
Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P, Poniachik J. Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond). 2004;106(6):635–43.
Article
CAS
Google Scholar
Nieminen P, Mustonen AM, Karja V, Asikainen J, Rouvinen-Watt K. Fatty acid composition and development of hepatic lipidosis during food deprivation--mustelids as a potential animal model for liver steatosis. Exp Biol Med (Maywood). 2009;234(3):278–86.
Article
CAS
Google Scholar
Pagadala M, Kasumov T, McCullough AJ, Zein NN, Kirwan JP. Role of ceramides in nonalcoholic fatty liver disease. Trends Endocrinol Metab. 2012;23(8):365–71.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li Y, Dong J, Ding T, Kuo MS, Cao G, Jiang XC, Li Z. Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor gamma2 suppression. Arterioscler Thromb Vasc Biol. 2013;33(7):1513–20.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bikman BT, Summers SA. Sphingolipids and hepatic steatosis. Adv Exp Med Biol. 2011;721:87–97.
Article
CAS
PubMed
Google Scholar