Table 4 Synovial fluid biomarkers (estimated means and ranges) before and after intra-articular injection of 3 μg E. coli O55:B5 lipopolysaccharide
| Â | White blood cell count (Fig. 4a) | Total protein (Fig. 4b) | Serum amyloid A (Fig. 4c) | Haptoglobin (Fig. 4d) | Iron (Fig. 4e) | Fibrinogen (Fig. 5a) | Thrombin-antithrombin (Fig. 5b) | D-dimer (Fig. 5c) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | × 109/L | g/L | mg/L | mg/L | μmol/L | g/L | μg/L | μg/mL | ||||||||
Hours relative to LPS injection | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range |
−120 | 0.2 | 0.1–0.5 | 4.0 | 2–12 | 0.9 | 0.5–1.1 | 239.9 | 97.1–458.8 | 12.1 | 7.2–14.6 | 0.18 | 0.0–0.5 | 44.6 | 13.1–240.0 | 1.6 | 0.7–3.4 |
−96 | 1.6 | 0.1–11.6 | 11.3* | 2–22 | 0.8 | <DL-1.5 | 817.9* | 207.2–5615.4 | 14.2 | 1.7–30.9 | 0.24 | 0.2–0.3 | 51.8 | 11.7–132.3 | 5.3 | 2.3–12.9 |
−24 | 0.6 | 0.2–2.0 | 6.5 | 2–12 | <DL | <DL-14.2 | 284.2 | 108.1–670.3 | 16.3 | 6.1–31.5 | 0.35 | 0.0–0.6 | 24.8 | 11.2–57.7 | 1.4 | 0.0–6.8 |
0 | 2.2* | 0.2–12.0 | 13.9*** | 6–30 | 0.5 | <DL-1.1 | 600.0 | 128.9–2091.4 | 23.4 | 6.2–37.3 | 0.29 | 0.2–0.6 | 53.3 | 13.1–124.8 | 4.9 | 0.3–19.5 |
2 | 46.4*** | 17.1–100.3 | 30.6*** | 14–48 | < DL | <DL-0.9 | 1166.3*** | 336.1–2391.3 | 23.7 | 14.0–33.8 | 0.60 | 0.3–1.0 | 720.0*** | >720.0 | 6.3 | 0.7–30.0 |
4 | 111.2*** | 45.5–207.5 | 45.9*** | 38–64 | <DL | <DL-0.9 | 1503.9*** | 531.7–2033.0 | 25.2 | 18.5–34.2 | 1.67*** | 1.2–2.1 | 720.0*** | >720.0 | 2.0 | 0.8–3.1 |
8 | 159.8*** | 145.3–182 | 51.8*** | 46–64 | 1.3 | 0.9–1.7 | 1811.7*** | 1149.3–2231.3 | 21.9 | 5.0–37.2 | 2.07*** | 1.8–2.6 | 504.5*** | 286.9–720.0 | 2.1 | 1.7–2.7 |
16 | 93.6*** | 58.0–114.0 | 54.6*** | 50–64 | 23.7*** | 3.5–135.4 | 1846.0*** | 1468.4–2492.1 | 13.0 | 1.3–21.0 | 1.67*** | 1.2–2.3 | 249.4*** | 145.5–396.7 | 2.9 | 2.5–3.6 |
24 | 55.8*** | 31.2–89.8 | 48.1*** | 36–60 | 82.9*** | 19.8–294.7 | 1180.2*** | 897.8–1575.0 | 9.0 | 6.9–11.9 | 1.44*** | 1.2–1.6 | 186.3** | 133.7–269.1 | 3.5 | 3.2–3.8 |
36 | 28.3*** | 14.8–47.5 | 44.7*** | 36–70 | 211.7*** | 45.6–905.8 | 1269.4*** | 435.3–3262.6 | 10.4 | 6.3–13.0 | 1.56*** | 1.1–1.8 | 151.7 | 81.2–234.7 | 6.2 | 3.3–17.4 |
48 | 22.1*** | 11.3–38.0 | 36.3*** | 29–46 | 231.2*** | 64.8–573.9 | 928.1** | 373.8–1346.0 | 14.9 | 8.0–20.7 | 1.33*** | 0.6–1.7 | 193.5** | 88.5–367.6 | 4.7 | 3.0–19.8 |
72 | 9.9*** | 3.5–48.0 | 31.8*** | 26–38 | 174.7*** | 50.6–470.1 | 619.2 | 307.9–991.5 | 17.2 | 13.3–25.3 | 1.07*** | 0.8–1.4 | 118.6 | 59.7–217.4 | 6.8 | 3.5–28.1 |
144 | 0.9 | 0.6–1.2 | 28.0*** | 20–40 | 2.1 | 0.2–29.1 | 696.1 | 528.0–1007.9 | 23.1 | 11.7–37.9 | 0.71 | 0.5–1.2 | 85.4 | 34.1–233.5 | 16.2*** | 9.6–20.9 |