Table 3 Blood biomarkers (estimated means and ranges) before and after intra-articular injection of 3 μg E. coli O55:B5 lipopolysaccharide
| Â | White blood cell count (Fig. 2a) | Total protein (Fig. 2b) | Serum amyloid A (Fig. 2c) | Haptoglobin (Fig. 2d) | Iron (Fig. 2e) | Fibrinogen (Fig. 3a) | Thrombin-antithrombin (Fig. 3b) | D-dimer (Fig. 3c) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | × 109/L | g/L | mg/L | mg/L | μmol/L | g/L | μg/L | μg/mL | ||||||||
Hours relative to LPS injection | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range | Estimated mean | Range |
−120 | 7.8 | 6.5–10.5 | 66.3 | 62.7–79.3 | < DL | < DL | 2056.1 | 886.8–2466.5 | 25.5 | 17.8–39.1 | 3.46 | 2.89–4.19 | 1.9 | 1.6–2.5 | 0.14 | 0.08–0.32 |
−96 | 7.7 | 5.7–10.9 | 66.2 | 63.7–81.5 | < DL | < DL- 1.2 | 2097.3 | 864.8–2509.0 | 28.2 | 18.5–48.9 | 3.48 | 3.00–4.19 | 1.7 | 1.2–2.2 | 0.15 | 0.10–0.35 |
−24 | 7.7 | 5.8–10.3 | 65.7 | 61.1–78.0 | < DL | < DL | 1955.0 | 812.3–2451.5 | 27.3 | 20.9–42.8 | 3.22 | 2.71–3.99 | 1.5 | 0.9–2.9 | 0.14 | 0.09–0.28 |
0 | 7.5 | 5.8–8.9 | 65.1 | 61.6–77.8 | < DL | < DL | 1908.2 | 802.6–2414.2 | 25.4 | 15.8–46.3 | 3.26 | 2.70–3.96 | 1.6 | 1.0–2.3 | 0.14 | 0.08–0.26 |
2 | 7.7 | 6.5–9.1 | 67.2 | 64.5–80.6 | < DL | < DL | 1964.2 | 806.4–2488.5 | 25.2 | 16.5–37.4 | 3.22 | 2.78–3.94 | 2.2 | 1.1–3.1 | 0.14 | 0.08–0.25 |
4 | 11.1*** | 7.2–15.0 | 67.2 | 64.0–84.5 | < DL | < DL | 1980.0 | 799.7–2609.2 | 24.7 | 16.6–32.0 | 3.56 | 2.72–4.28 | 2.4 | 1.3–4.5 | 0.15 | 0.12–0.29 |
8 | 12.2*** | 10.1–16.1 | 68.3 | 64.5–80.4 | 2.2 | 0.8–8.0 | 2009.3 | 868.4–2642.5 | 17.9 | 12.8–26.1 | 3.43 | 2.99–4.16 | 2.5 | 1.6–3.7 | 0.14 | 0.09–0.28 |
16 | 11.2*** | 8.8–14.1 | 69.6 | 64.9–80.8 | 189.0*** | 69.0–292.6 | 2403.8* | 1180.2–2982.0 | 7.8*** | 6.8–10.1 | 4.05 | 3.64–4.53 | 2.1 | 1.3–4.0 | 0.14 | 0.11–0.30 |
24 | 9.5*** | 7.5–11.0 | 67.1 | 64.5–78.7 | 459.3*** | 195.8–735.5 | 2636.6*** | 1507.5–3161.3 | 7.3*** | 6.4–8.6 | 4.20* | 2.77–4.80 | 2.1 | 1.0–3.2 | 0.12 | 0.05–0.30 |
36 | 10.4*** | 8.1–11.9 | 66.2 | 66.6–78.6 | 780.4*** | 282.8–1176.4 | 3041.3*** | 2143.8–3359.8 | 17.9 | 13.5–27.8 | 5.07*** | 4.68–5.76 | 1.9 | 1.2–2.5 | 0.13 | 0.08–0.29 |
48 | 8.7 | 6.6–11.1 | 66.2 | 63.8–79.2 | 791.3*** | 281.5–1240.3 | 3284.3*** | 2626.4–3813.8 | 25.9 | 13.7–38.9 | 5.06*** | 4.42–6.09 | 1.5 | 1.0–2.4 | 0.13 | 0.08–0.27 |
72 | 7.8 | 5.6–10.0 | 65.3 | 63.1–77.2 | 552.4*** | 198.7–976.9 | 3166.3*** | 2727.6–3451.3 | 22.1 | 18.4–32.7 | 4.90*** | 4.12–5.75 | 1.8 | 0.9–3.5 | 0.13 | 0.07–0.28 |
144 | 7.0 | 5.5–8.4 | 66.8 | 63.0–82.5 | 10.5** | <DL-96.8 | 2746.6*** | 1617.1–3261.0 | 26.0 | 18.8–39.5 | 4.43** | 3.74–5.34 | 2.3 | 1.1–3.8 | 0.16 | 0.11–0.26 |