Nasal tissue-derived hamartoma in the maxillary gingiva of a calf
© Tsuka et al. 2016
Received: 10 July 2015
Accepted: 14 January 2016
Published: 22 January 2016
All of oral hamartomas has been previously found in mandibular gingiva in younger calves, and were histologically diagnosed as a vascular hamartoma. This is the first case report describing a calf with a mass in the maxillary gingiva that was histologically diagnosed as a nasal tissue-derived hamartoma.
A 13-day-old male Holstein calf presented with a horn-like mass in the left rostral maxillary gingiva. Surgical removal revealed that the mass had a dual structure composed of cartilaginous and soft tissues and extended deeply toward the nasal cavity. Excised tissues mainly consisted of two types of mature cells without mitotic figures and atypia: 1) the cartilage-like structures consisted of an island and a meandering massive focus of mature cartilaginous tissues, and 2) tubular structures consisting of stratified ciliated mucosal columnar cells with gland-like structures and aggregated goblet cells. The mass was diagnosed as a nasal tissue-derived hamartoma because these two types of structures were histologically identical to nasal structures. The present case had no recurrence at 1 year after surgery.
To our knowledge, this is the first description of the calf with nasal tissue-derived hamartoma in the maxillary gingiva.
Hamartomas have been defined as excessive focal overgrowths of mature cells in organs of identical cellular elements [1, 2]. Most hamartomas are present at birth and differ from true tumors by showing growth coordinated with the surrounding tissues . In bovines, the tissues of such congenital lesions arise from various organs and are classified as vascular [1–4], fibrous , and/or bronchiolar and alveolar structures . Gingival hamartomas have occasionally been reported in younger calves [1–4], and have been grossly characterized as flat, reddish masses located on the mandibular gingiva [1–4]. All such lesions have been histologically diagnosed as vascular hamartomas [1–4]. The present report describes the specific gross appearance and histological findings of a mass observed in the maxillary gingiva of a newborn calf, which differed from those of previous gingival vascular hamartomas.
Gingival hamartomas have been occasionally reported in calves ranging in age from 1 day to 2.5-months [1–4], and were diagnosed as vascular hamartomas based on pathological findings of large numbers of disorganized capillaries lined by mature endothelial cells . The pathological findings of the present case can be summarized as follows: 1) the mass was comprised of cartilage-like structures, and tubular structures consisting of stratified ciliated mucosal columnar cells and gland-like structures; 2) the cellular composition in the cartilage-like and tubular structures of the mass were identical to those commonly found in nasal cavities; and 3) all structures were formed by proliferation of normal mature cells without mitotic abnormalities. Based on these histological findings, the mass was diagnosed as a nasal tissue-derived hamartoma.
There are large differences in the gross appearance of gingival vascular hamartomas versus nasal tissue-derived hamartoma. Gingival vascular hamartomas are characterized as reddish-colored flat masses (2–7 cm in widths and 1.5 cm in heights), whereas nasal tissue-derived hamartoma are a horn-like mass (1.5 cm in width and 3.5 cm in height) colored similar to the gingival mucosa [1–4]. Moreover, nasal tissue-derived hamartomas in the maxillary gingiva have different locations than gingival vascular hamartomas, which have been found in the rostral levels of the mandibular gingiva [1–4]. The cause of this difference may be that the presently described lesion originated from nasal structures and protruded to the oral cavity.
Hamartomas derived from nasal structures have been described in humans and cats [7–11]. Most human and feline patients with various types of nasal hamartomas have presented with upper respiratory signs, and the lesions were observed within the nasal cavity [7–11]. However, there are reported cases in which the lesions were first discovered during the course of a dental examination , which resembles the present case showing a clinical pattern of a nasal lesion that invaded the oral cavity. In human patients, nasal hamartomas have been reported to be predominantly composed of mesenchymal tissues (called as nasal chondromesenchymal hamartomas) or epithelial tissues (called as respiratory epithelial adenomatoid hamartomas) . Nasal chondromesenchymal hamartomas are characterized by a mixture of mesenchymal elements (spindle cells, and collagen fibers) and irregular islands of osseous and chondroid tissues . Respiratory epithelial adenomatoid hamartomas are characterized by formation of large and small adenomatoid structures lined by ciliated respiratory epithelium .
The present case was likely to have pathological findings identical to a mixture of these two types of lesions. Some human patients have been reported to have a respiratory epithelial adenomatoid hamartoma component together with an additional chondro-osseous component . In veterinary medicine, nasal hamartomas have been reported in six feline cases: one case was diagnosed as a nasal vascular hamartoma and five cases were diagnosed as nasal mesenchymal hamartomas [10, 11]. Feline nasal mesenchymal hamartoma is diagnosed based on the pathological finding of the tissues mainly comprised of various mesenchymal components including cartilage, woven bone, and spindle cells . Pathological findings of these lesions would be similar to those of nasal chondromesenchymal hamartomas in humans . Nasal epithelial lesions identical to respiratory epithelial adenomatoid hamartomas in humans have not previously been reported in veterinary medicine. The present case may be the first reported animal case presenting with a mixed-type nasal hamartoma comprised of both epithelial and mesenchymal tissues.
To our knowledge, this is the first description of a calf with a nasal tissue-derived hamartoma in the maxillary gingiva. Nasal tissue-derived hamartoma is an unusual lesion pathologically identical to a combination of nasal chondromesenchymal hamartoma and respiratory epithelial adenomatoid hamartoma in veterinary species.
All diagnostic and therapeutic procedures were performed by the approved veterinarians in the course of routine veterinary health management.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Wilson RB. Gingival vascular hamartoma in three calves. J Vet Diagn Invest. 1990;2:338–9.View ArticlePubMedGoogle Scholar
- Sheahan BJ, Donnelly WJC. Vascular hamartomas in the gingiva of two calves. Vet Pathol. 1981;18:562–4.PubMedGoogle Scholar
- Stanton ME, Meunier PC, Smith DF. Vascular hamartoma in the gingiva of two neonatal calves. J Am Vet Med Assoc. 1984;184:205–6.PubMedGoogle Scholar
- Yeruham I, Abramovitch I, Perl S. Gingival vascular hamartoma in two calves. Aust Vet J. 2004;82:152–3.View ArticlePubMedGoogle Scholar
- Lafond JF, Mulon PY, Drolet R. Fibrous vaginal hamartoma in a newborn calf. Can Vet J. 2008;49:61–2.PubMed CentralPubMedGoogle Scholar
- Roth L, Bradley GA. Pulmonary hamartoma in a calf. J Comp Pathol. 1991;105:471–4.View ArticlePubMedGoogle Scholar
- Kessler HP, Unterman B. Respiratory epithelial adenomatoid hamartoma of the maxillary sinus presenting as a periapical radiolucency: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97:607–12.View ArticlePubMedGoogle Scholar
- Hsueh C, Hsueh S, Gonzalez-Crussi F, Lee T, Su J. Nasal chondromesenchymal hamartoma in children: report of 2 cases with review of the literature. Arch Pathol Lab Med. 2001;125:400–3.PubMedGoogle Scholar
- McDermott MB, Ponder TB, Dehner LP. Nasal chondromesenchymal hamartoma: an upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol. 1998;22:425–33.View ArticlePubMedGoogle Scholar
- Greci V, Mortellaro CM, Olivero D, Cocci A, Hawkins EC. Inflammatory polyps of the nasal turbinates of cats: an argument for designation as feline mesenchymal nasal hamartoma. J Feline Med Surg. 2011;13:213–9.View ArticlePubMedGoogle Scholar
- Chambers BA, Laksito MA, Fliegner RA, McCowan C, Beck C, Yates GD. Nasal vascular hamartoma in a Domestic Shorthair cat. Aust Vet J. 2010;88:107–11.View ArticlePubMedGoogle Scholar