- Research article
- Open Access
Abdominal obesity is associated with heart disease in dogs
BMC Veterinary Research volume 10, Article number: 131 (2014)
The relationship between overall obesity and fat distribution in dogs and the development of heart disease is unclear. In the present study we evaluated the association between overall obesity and fat distribution and clinical heart disease by morphometric and computed tomography (CT)-based measurements. Body condition score (BCS), modified body mass index (MBMI, kg/m2), waist-to-hock-to-stifle distance ratio (WHSDR), waist-to-ilium wing distance ratio (WIWDR), and waist-to-truncal length ratio (WTLR) were compared between dogs with (n = 44) and without (n = 43) heart disease using receiver operating characteristic (ROC) analysis. Intra-abdominal fat (IAF) and subcutaneous fat (SQF) were measured in dogs with (n = 8) and without (n = 9) heart disease at the center of the fourth and fifth lumbar vertebrae by CT.
BCS was similar between heart disease and healthy groups (3.6 ± 0.2 vs. 3.3 ± 0.1, P = 0.126). The following morphometric measurements were greater in the heart disease group compared with healthy canines: MBMI (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2, respectively, P = 0.035); WIWDR (4.1 ± 0.1 vs. 3.1 ± 0.1, P < 0.01); and WTLR (1.25 ± 0.04 vs. 1.05 ± 0.04, P < 0.01). However, there was no significant difference in WHSDR (3.6 ± 0.1 vs. 3.7 ± 0.2, P = 0.875). Interestingly, IAF was significantly increased in dogs with heart disease compared with healthy dogs (23.5 ± 1.5% vs. 19.4 ± 1.2%, P = 0.039) whereas SQF was similar between two groups (35.5 ± 2.7% vs. 38.6 ± 3.5%, P = 0.496). Of the five morphometric indices studied, WIWDR and WTLR provided acceptable discrimination for diagnosing heart disease in dogs, with areas under the ROC curve of 0.778 (95% confidence interval [CI]:0.683-0.874) and 0.727 (95% CI:0.619-0.835), respectively.
Our data indicate that abdominal obesity, rather than overall obesity, is associated with heart disease in dogs. Measurements of both WIWDR and WTLR are particular useful for detection of an abdominal obesity in dogs.
Clinical assessments of human patients have emphasized the importance of accumulated visceral fat rather than peripheral fat as one of the underlying causes of heart disease [1, 2]. Visceral obesity is also associated with insulin insensitivity , which can result in various metabolic abnormalities and health complications. Dogs commonly become overweight as a result of unintentional overfeeding and approximately 24-30% of the pet dog population is estimated to be overweight . Various diseases in dogs, including heart disease [5, 6], metabolic dysregulation (i.e., diabetes) [7, 8], osteoarthritis , urinary tract and reproductive disorders [10, 11], and neoplasia  are linked to being overweight.
Measurement of obesity including relative body weight (BW) , body condition score (BCS) [13–15], morphometric analysis , and dimensional evaluation (performed by tape measurement) , provides a convenient evaluation of a dog’s general body composition [14, 15]. However, visceral fat cannot be assessed with these measurements. In clinical settings, CT provides a minimally invasive method for peripheral and visceral fat measurement [16, 17]. In humans, altered body conformation, especially the presence of abdominal obesity, might enhance the risk of heart disease . In addition, heart disease is associated with numerous morphometric and dimensional measurements. Clinical appraisal of canine abdominal obesity allows veterinarians to warn owners to pay more attention to their pet’s obesity problem and the resulting increased risk of developing heart disease. The present study comprehensively compared BCS, body shape, and visceral fat between healthy dogs and those with heart disease.
We evaluated 87 dogs that were patients of Kasetsart University Veterinary Teaching Hospital over a 2-year period (October 2005 to October 2007). The protocol was reviewed and approved by Kasetsart University Animal Care and Use Committee, and informed consent was obtained from all owners. Of these 87 dogs, 43 were physically healthy and 44 were determined to have heart disease and visited the heart clinic for physical check-ups (Table 1). In the healthy group, there were 11 (25.6%) Poodle, 7 (16.3%) mixed-breed dogs, 7 (16.3%) Shih Tzu, 3 (7%) Golden Retriever, 2 (4.7%) Chihuahua, 2 (4.7%) English Cocker, 2 (4.7%) Pugs, and 9 (20.9%) other breeds. In the heart disease group, there were 18 (40.9%) mixed-breed dogs, 9 (20.5%) Poodles, 2 (4.5%) Cocker Spaniel, 2 (4.5%) Miniature Pincher, 2 (4.5%) Pomeranian, 2 (4.5%) Shih Tzu, and 9 (20.5%) other breeds. Sex distribution (dogs with heart disease: 19 sexually intact males, 7 castrated males, 10 sexually intact females, and 8 spayed females; control dogs: 19 sexually intact males, 4 castrated males, 17 sexually intact females, and 3 spayed females) did not differ significantly between groups. Of the 44 dogs with heart disease, 17 had cardiac enlargement, 13 had valvular heart disease, 7 had cardiac arrhythmia, 6 had congestive heart failure, and 1 had cardiomyopathy. In addition, among heart disease dogs, four were positive for heartworm.
Body condition score and morphometric measurement
Various clinical assessments of canine body composition were performed. Body condition score was recorded using a five-point scale (1 = very thin, 2 = underweight, 3 = ideal weight, 4 = overweight, and 5 = obese) [14, 15]. Evaluation of body dimensions was performed by tape measurement. Truncal length (TL, cm) the length of the dog body measured from the front of the chest at the shoulder level to the point of buttock. The body mass index (BMI) is a measurement of human body shape based on mass and height (kg/m2). Because dogs walk on four legs, truncal length rather than height was used for MBMI calculation. Therefore, the modified body mass index (MBMI) was defined as the dog’s body weight divided by the truncal length in meters squared (BW (kg)/[TL (m)]2). Waist circumference (WC, cm) was measured over a dorsal spine of the 4th lumbar vertebrae using a measuring tape wrapping around the dog abdomen approximately midway between the last rib and the iliac crest in a standing position. Ilium wing distance (IWD, cm) is the width between the dorsal iliac crests. Hock-to-stifle distance (HSD, cm) is a distance from the knee joint to the hock joint. Various relative waist circumference measures including waist-to-ilium wing distance ratio (WIWDR), waist-to-truncal length ratio (WTLR) and waist-to-hock-to-stifle distance ratio (WHSDR) were used in the present study.
With the owners’ consents, 17 dogs (9 healthy and 8 heart disease dogs) with body condition scores between 4–5 were randomly selected for CT scan for assessment of the subcutaneous and visceral fat. Dogs were fasted for 12 hours prior to the study. They were sedated by intravenous injection of diazepam (0.5 mg/kg) and anesthesia was induced with intravenous propofol (2 mg/kg body weight). After endotracheal intubation, anesthesia was maintained with isoflurane inhalation (2% in 100% oxygen). All dogs were positioned in sternal recumbency before operating a conventional CT scanner (Philips TOMOSCAN CX/Q, the Netherland). The acquisition parameters were: 120 kVP; 200 mA; field of view 240 mm; collimation,10 mm, and scanning time 4 s/rotation. Slices were acquired from the center of the fourth and fifth lumbar vertebrae. To determine the distribution of visceral and subcutaneous fat, digital image data sets obtained from individual dogs were analyzed using a range of −135 to −105 HU, and then intra-abdominal fat (IAF) and subcutaneous fat (SQF) area were measured and normalized to total abdominal area.
Differences between the two groups were compared using Tukey’s HSD test. Correlations between morphometric measurements in this study were tested with a pair-wise Pearson study. Data were expressed as mean ± S.E and were compared using one-way analysis of variance. Receiver operating characteristic (ROC) analysis was used to compare the performance of BCS, MBMI, WHSDR, WIWDR, and WTLR as indices of central obesity by determining the diagnostic power of the test by measuring the area under the curve (AUC) using STATA12 (Stata Inc., College Station, TX, USA) statistical software. A perfect test is going to have an AUC of 1.0 and an AUC of 0.5 means the test performs no better than chance. Youden’s index (Youden’s J statistic; J = Sensitivity + specificity - 1) was applied to identify the optimal cut-off value of the morphometric measurements that yielded maximum sums from the ROC curves. Logistic regression analysis was used to determine the odds ratios of cardiovascular disease in dogs associated with either WIWDR or WTLR at the optimal cut-off value. All statistical comparisons were two-tailed, and P-values <0.05 were considered statistically significant.
The average BCS in the heart disease group was slightly higher than that in the healthy group but the difference was not significant (3.6 ± 0.2 vs. 3.3 ± 0.1, P = 0.126). There was also no significant difference in BCS between heart disease and healthy groups when animals were analyzed according to gender: 3.4 ± 0.2 vs. 3.2 ± 0.2 (P = 0.4293) for males and 3.8 ± 0.2 vs. 3.3 ± 0.2 (P = 0.701) for females (Figure 1). The average MBMI in the heart disease group was significantly higher than that in healthy animals (65.0 ± 4.5 vs. 52.5 ± 3.7 kg/m2; P = 0.035) (Table 1).
To compare abdominal obesity of healthy versus heart disease dogs, the relative waist circumference was assessed using three different ratios (WIWDR, WHSDR, and WTLR). For WHSDR, no difference was observed between heart disease and healthy groups (3.6 ± 0.1 vs. 3.7 ± 0.2, respectively; P = 0.875). However, dogs with heart disease possessed significantly higher WIWDR (heart disease 4.1 ± 0.1 vs. healthy 3.1 ± 0.1; P < 0.01) and WTLR (heart disease 1.25 ± 0.04 vs. healthy 1.05 ± 0.04; P < 0.01) than healthy dogs (Table 1).
Correlation analyses of fat measurements revealed that BCS was positively correlated with MBMI (r = 0.494, P < 0.01), WHSDR (r = 0.553, P < 0.01) and WTLR (r = 0.572, P < 0.01), but not with WIWDR (r = 0.182, P > 0.05) (Table 2). Furthermore, MBMI was significantly correlated with WIWDR (r = 0.303, P < 0.01) and WTLR (r = 0.690, P < 0.01), but not with WHSDR (r = 0.130, P > 0.05) (Table 2).We used CT to assess IAF and SQF at the center of the fourth and fifth vertebrae in dogs with or without heart disease (Figure 2). There was no significant difference in SQF between dogs in the heart disease group and those in the healthy group (35.5 ± 2.7% vs. 38.6 ± 3.5%, respectively; P = 0.50) (Figure 3); however, the amount of IAF of dogs in the heart disease group was significantly higher than that in the healthy group (23.5 ± 1.5% vs. 19.4 ± 1.2%; P = 0.04) (Figure 3). Moreover, the level of SQF was significantly higher than the level of IAF in both the heart disease and the healthy group.
Performance of the indices of central obesity
The AUCs from the ROC analyses of BCS, MBMI, WHSDR, WIWDR, and WTLR for predicting the presence of cardiovascular disease in dogs were shown in Table 3. The AUCs from the ROC analyses of MBMI, WIWDR, and WTLR were significant different, compared with the null hypothesis true area of 0.5. The largest area under the ROC curve was obtained using WIWDR (AUC = 0.778; 95% CI:0.683-0.874), followed by WTLR (AUC = 0.727; 95% CI:0.612-0.835) (Table 3).
The cut-off point between sensitivity and specificity curves for WIWDR was 3.6, which also corresponded to the highest Youden’s index (44.82%). The WIWDR cut-off point of 3.6 gave 72.73% sensitivity and 72.09% specificity (Table 4). Dog with WIWDR higher than 3.6 were 7-fold (odds ratios: 6.9 ; 95% CI: 2.7-17.6, p < 0.01) more likely to have cardiovascular diseases than dogs without this factor. The cut-off point between sensitivity and specificity curves for the WTLR was 1.1, which gave 63.64% sensitivity and 67.44% specificity. The optimal cut-off point for WTLR was 1.2, which corresponded to the highest Youden’s index (35.95%). Using a cut-off of 1.2 for the WTLR resulted in a significant improvement in specificity to 81.40%; however, the sensitivity was slightly reduced to 54.55% (Table 4). Dogs with WTLR higher than 1.2 were 5-fold (odds ratios: 5.2; 95% CI: 2.0-13.9, p < 0.01) more likely to have cardiovascular diseases than dogs without this factor.
In the present study we compared BCS, MBMI, and abdominal obesity between healthy dogs and dogs affected with heart disease. The average BCS was comparable between healthy dogs and dogs with heart disease; however, the average MBMI was significantly higher in dogs with heart disease than in healthy dogs. Furthermore, the relative waist circumference indices including the WIWDR and the WTLR, but not the WHSDR, were higher in dogs with heart disease compared with healthy dogs, suggesting that dogs with abdominal obesity have a higher chance of developing heart disease. The pair-wise correlation study indicated an association among BCS, MBMI, and morphometric measurements, and suggests a strong association between fat accumulation and body conformation change. Furthermore, the amount of intra-abdominal fat in dogs with heart disease was significantly higher than that in healthy dogs although the amount of subcutaneous fat did not differ significantly between the groups.
The number of dogs with heart disease that were older than 5 years old enrolled in the present study were found more than the healthy group. The different of age distribution between healthy group and heart disease group may be due to the fact that heart diseases are commonly found in the older dogs [19, 20]. Due to the fact that dogs may gain weight with aging and desexing that may influence the study results. In the present study, sex distribution did not differ significantly between groups and the majority of the population were intact dogs. Moreover, the body condition scores were comparable between dogs with and without heart diseases groups (Table 1). Measuring the relative abdominal obesity using our study revealed that relative abdominal obesity by measuring WIWDR and WTLR suggested the present of abdominal obesity in dogs with heart disease compared to the healthy group (Table 1).
In humans, central obesity (determined by waist circumference) in association with various morbidities including dyslipidemia , hypertension , and glucose intolerance  is linked to metabolic dysfunction that leads to the development of cardiovascular diseases  and diabetes mellitus . Interestingly, canine obesity is also relevant to the development of insulin resistance , altered lipid profiles , and mild hypertension  that could be improved by weight reduction . The results of this CT-based study indicate increased IAF in dogs with heart disease compared with healthy dogs. Despite the evidence of an increase in visceral fat in dogs with heart disease, the pathophysiological roles of visceral fat on increased risk of cardiovascular diseases in dogs remain elusive .
Waist circumference has been shown to be an independent risk factor for heart disease in humans . It has been hypothesized that abdominal obesity provides biologic evidence of underlying metabolic disturbances . Therefore, waist circumference has been used in human medicine as a surrogate marker of abdominal fat mass  that is associated with cardiometabolic disease risk [21, 23]. In veterinary medicine, dogs with abdominal obesity cannot be identified directly from measurement of waist circumference because of variations in body size among different dog breeds. Therefore we used various alternative morphometrics in the present study to assess canine waist circumference including WHSDR, WIWDR, and WTLR. Body condition score was associated with WHSDR and WTLR whereas modified body mass index was associated with WIWDR and WTLR. Thus, WIWDR and WTLR may provide a better assessment of increased relative waist circumference and overall body fat in dogs.
Human studies have identified various anthropometric indices that are cardiovascular disease risk factors including BMI [1, 32], waist circumference [1, 29, 31], waist-to-hip ratio , and waist-to-height ratio [32, 33]. In the present study, the morphometric indices that provided acceptable discrimination (AUC ≥0.7) between healthy dogs and those with heart disease were WIWDR and WTLR, with AUC for the ROC curve of 0.778 (95% CI:0.683-0.874) and 0.727 (95% CI:0.619-0.835), respectively. Both WIWDR and WTLR provide a simple assessment by which veterinarians can readily identify canine patients at increased risk of developing heart disease. The relative waist circumference may provide a basis for future staging systems for dogs with heart disease, to which further discriminatory variables might be added.
Despite the obvious strength of using WIWDR and WTLR to predict the risk of canine heart disease, it should be noted that a relatively small number of animals were enrolled in this study (87 cases). Waist circumference is widely accepted in human medicine as a strong independent risk factor of heart disease [1, 29, 31]. Developing novel specific body measurements in dogs for monitoring abdominal obesity will significantly improve the detection rate of dogs at risk of developing cardiovascular diseases. In the present study, measurement of subcutaneous and intra-abdominal fat was performed in only 17 cases, thus limiting the strength of the comparison of relative waist circumference with computed tomographic information. However, the main objective of the present study was to establish the performance of relative waist circumference parameters (WIWDR and WTLR) compared with conventional parameters such as body condition score. Nonetheless, the accumulation of intra-abdominal fat identified by CT was higher in dogs with heart disease compared with healthy dogs, indicating that excess visceral fat is associated with cardiovascular disease in canine patients, similar to humans .
Significant for comparative research
Various hormones, metabolically active proteins and adipokines act as inflammatory mediators, promoting the chronic inflammatory state in obesity . In human, visceral obesity has been associated with noninfectious inflammation  that has been linked to development of metabolic syndrome and increase incidence of cardiovascular disease and diabetes . Interestingly, the present study associated the presence of abdominal obesity in dogs with heart disease similar to that found in humans [31, 32, 36]. The similarities in living environment and the diet of humans and dogs gives rise to the possibility that canine visceral obesity may be a good model for the disease in human patients with abdominal obesity. Nevertheless, the mechanisms of how abdominal obesity leaded to development of heart disease in canine patients was not conducted in the present study. Additional studies of disease pathogenesis, identification of novel non-invasive diagnostic markers, and the development of novel therapeutic agents for management of abdominal obesity for canine patients should be conducted and could also benefit other species.
In conclusion, abdominal obesity, rather than overall obesity, was associated with heart disease in dogs. Increased relative waist circumference, especially a WIWDR greater than 3.6 or a WTLR greater than 1.2, may provide useful means of assessing cardiovascular disease risk status associated with the presence of an abdominal obesity in dogs. Because abdominal obesity puts dog at risk of serious medical problems including cardiovascular disease, veterinarians should raise awareness about the dangers of canine obesity and the long-term medical consequences.
Area under the curve
Body condition score
Modified body mass index
Receiver operating characteristic
Waist-to-hock-to-stifle distance ratio
Waist-to-ilium wing distance ratio
Waist-to-truncal length ratio.
Snell-Bergeon JK, Hokanson JE, Kinney GL, Dabelea D, Ehrlich J, Eckel RH, Ogden L, Rewers M: Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium. Int J Obes Relat Metab Disord. 2004, 28 (12): 1594-1599. 10.1038/sj.ijo.0802796.
Nasir K, Campbell CY, Santos RD, Roguin A, Braunstein JB, Carvalho JA, Blumenthal RS: The association of subclinical coronary atherosclerosis with abdominal and total obesity in asymptomatic men. Prev Cardiol. 2005, 8 (3): 143-148.
Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes. 1997, 46 (10): 1579-1585. 10.2337/diacare.46.10.1579.
Burkholder WJ: Use of body condition scores in clinical assessment of the provision of optimal nutrition. J Am Vet Med Assoc. 2000, 217 (5): 650-654. 10.2460/javma.2000.217.650.
Bodey AR, Michell AR: Epidemiological study of blood pressure in domestic dogs. J Small Anim Pract. 1996, 37 (3): 116-125. 10.1111/j.1748-5827.1996.tb02358.x.
Truett AA, Borne AT, Monteiro MP, West DB: Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog. Obes Res. 1998, 6 (2): 137-146. 10.1002/j.1550-8528.1998.tb00328.x.
Tvarijonaviciute A, Ceron JJ, Holden SL, Cuthbertson DJ, Biourge V, Morris PJ, German AJ: Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome. BMC Vet Res. 2012, 8: 147-10.1186/1746-6148-8-147.
Laflamme DP: Companion animals symposium: obesity in dogs and cats: what is wrong with being fat?. J Anim Sci. 2012, 90 (5): 1653-1662. 10.2527/jas.2011-4571.
Kealy RD, Lawler DF, Ballam JM, Lust G, Smith GK, Biery DN, Olsson SE: Five-year longitudinal study on limited food consumption and development of osteoarthritis in coxofemoral joints of dogs. J Am Vet Med Assoc. 1997, 210 (2): 222-225.
Holt PE: Urinary incontinence in the dog and cat. Tijdschr Diergeneeskd. 1987, 112 (Suppl 1): 92S-97S.
Lekcharoensuk C, Lulich JP, Osborne CA, Pusoonthornthum R, Allen TA, Koehler LA, Urlich LK, Carpenter KA, Swanson LL: Patient and environmental factors associated with calcium oxalate urolithiasis in dogs. J Am Vet Med Assoc. 2000, 217 (4): 515-519. 10.2460/javma.2000.217.515.
Sonnenschein EG, Glickman LT, Goldschmidt MH, McKee LJ: Body conformation, diet, and risk of breast cancer in pet dogs: a case–control study. Am J Epidemiol. 1991, 133 (7): 694-703.
Laflamme DP: Nutrition for aging cats and dogs and the importance of body condition. Vet Clin North Am Small Anim Pract. 2005, 35 (3): 713-742. 10.1016/j.cvsm.2004.12.011.
Lund EM, Armstrong PJ, Gray MM, Ostrander EA: Prevalence and risk factors or obesity in adult dogs from private US veterinary practices. Intern J Appl Res Vet Med. 2006, 4 (2): 177-186.
German AJ: The growing problem of obesity in dogs and cats. J Nutr. 2006, 136 (7 Suppl): 1940S-1946S.
Ishioka K, Okumura M, Sagawa M, Nakadomo F, Kimura K, Saito M: Computed tomographic assessment of body fat in beagles. Vet Radiol Ultrasound. 2005, 46 (1): 49-53. 10.1111/j.1740-8261.2005.00009.x.
Kobayashi J, Tadokoro N, Watanabe M, Shinomiya M: A novel method of measuring intra-abdominal fat volume using helical computed tomography. Int J Obes Relat Metab Disord. 2002, 26 (3): 398-402. 10.1038/sj.ijo.0801921.
Turcato E, Bosello O, Di Francesco V, Harris TB, Zoico E, Bissoli L, Fracassi E, Zamboni M: Waist circumference and abdominal sagittal diameter as surrogates of body fat distribution in the elderly: their relation with cardiovascular risk factors. Int J Obes Relat Metab Disord. 2000, 24 (8): 1005-1010. 10.1038/sj.ijo.0801352.
Oyama MA, Fox PR, Rush JE, Rozanski EA, Lesser M: Clinical utility of serum N-terminal pro-B-type natriuretic peptide concentration for identifying cardiac disease in dogs and assessing disease severity. J Am Vet Med Assoc. 2008, 232 (10): 1496-1503. 10.2460/javma.232.10.1496.
Detweiler DK, Patterson DF, Hubben K, Botts RP: The prevalence of spontaneously occurring cardiovascular disease in dogs. A J P H. 1961, 51 (2): 228-241.
Carr MC, Brunzell JD: Abdominal obesity and dyslipidemia in the metabolic syndrome: importance of type 2 diabetes and familial combined hyperlipidemia in coronary artery disease risk. J Clin Endocrinol Metab. 2004, 89 (6): 2601-2607. 10.1210/jc.2004-0432.
Scaglione R, Argano C, di Chiara T, Colomba D, Parrinello G, Corrao S, Avellone G, Licata G: Central obesity and hypertensive renal disease: association between higher levels of BMI, circulating transforming growth factor beta1 and urinary albumin excretion. Blood Press. 2003, 12 (5–6): 269-276.
Laitinen T, Lindstrom J, Eriksson J, Ilanne-Parikka P, Aunola S, Keinanen-Kiukaanniemi S, Tuomilehto J, Uusitupa M: Cardiovascular autonomic dysfunction is associated with central obesity in persons with impaired glucose tolerance. Diabet Med. 2011, 28 (6): 699-704. 10.1111/j.1464-5491.2011.03278.x.
Ritchie SA, Connell JM: The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis. 2007, 17 (4): 319-326. 10.1016/j.numecd.2006.07.005.
Nakatsuji H, Kishida K, Kitamura T, Nakajima C, Funahashi T, Shimomura I: Dysregulation of glucose, insulin, triglyceride, blood pressure, and oxidative stress after an oral glucose tolerance test in men with abdominal obesity. Metabolism. 2010, 59 (4): 520-526. 10.1016/j.metabol.2009.08.013.
Mori N, Lee P, Kondo K, Kido T, Saito T, Arai T: Potential use of cholesterol lipoprotein profile to confirm obesity status in dogs. Vet Res Commun. 2011, 35 (4): 223-235. 10.1007/s11259-011-9466-x.
German AJ, Hervera M, Hunter L, Holden SL, Morris PJ, Biourge V, Trayhurn P: Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs. Domest Anim Endocrinol. 2009, 37 (4): 214-226. 10.1016/j.domaniend.2009.07.001.
Verkest KR: Is the metabolic syndrome a useful clinical concept in dogs? A review of the evidence. Vet J. 2014, 199 (1): 24-30. 10.1016/j.tvjl.2013.09.057.
Okafor CI, Fasanmade O, Ofoegbu E, Ohwovoriole AE: Comparison of the performance of two measures of central adiposity among apparently healthy Nigerians using the receiver operating characteristic analysis. Indian J Endocrinol Metab. 2011, 15 (4): 320-326. 10.4103/2230-8210.85588.
Grundy SM, Hansen B, Smith SC, Cleeman JI, Kahn RA: Clinical management of metabolic syndrome: report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol. 2004, 24 (2): e19-e24. 10.1161/01.ATV.0000112379.88385.67.
Pouliot MC, Despres JP, Lemieux S, Moorjani S, Bouchard C, Tremblay A, Nadeau A, Lupien PJ: Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol. 1994, 73 (7): 460-468. 10.1016/0002-9149(94)90676-9.
Lin WY, Lee LT, Chen CY, Lo H, Hsia HH, Liu IL, Lin RS, Shau WY, Huang KC: Optimal cut-off values for obesity: using simple anthropometric indices to predict cardiovascular risk factors in Taiwan. Int J Obes Relat Metab Disord. 2002, 26 (9): 1232-1238. 10.1038/sj.ijo.0802040.
Hsieh SD, Yoshinaga H: Abdominal fat distribution and coronary heart disease risk factors in men-waist/height ratio as a simple and useful predictor. Int J Obes Relat Metab Disord. 1995, 19 (8): 585-589.
Fontana L, Eagon JC, Trujillo ME, Scherer PE, Klein S: Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 2007, 56 (4): 1010-1013. 10.2337/db06-1656.
Klein BE, Klein R, Lee KE: Components of the metabolic syndrome and risk of cardiovascular disease and diabetes in Beaver Dam. Diabetes Care. 2002, 25 (10): 1790-1794. 10.2337/diacare.25.10.1790.
Bastien M, Poirier P, Lemieux I, Despres JP: Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014, 56 (4): 369-381. 10.1016/j.pcad.2013.10.016.
This study was supported by grants from Kasetsart University Research and Development Institute (KURDI) and the National Research Council of Thailand. Preliminary results were presented as an abstract at the 2014 ACVIM Forum, Nashville, TN, June 4th-7th, 2014.
All authors declare that they have no competing interests.
NT research design, conduct research, data analysis, manuscript preparation; WT analysis of the computed tomographic data, manuscript revision; SK data analysis, manuscript revision; AS conduct research, manuscript revision. All authors read and approved the final manuscript.
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Thengchaisri, N., Theerapun, W., Kaewmokul, S. et al. Abdominal obesity is associated with heart disease in dogs. BMC Vet Res 10, 131 (2014). https://doi.org/10.1186/1746-6148-10-131
- Abdominal obesity
- Heart disease
- Receiver operating characteristic
- Waist circumference
- Computed tomography