Table 2 Median (25–75th percentile) data of serum levels of cytokines in dogs with Diabetes mellitus (n = 16) and controls (total, n = 45) with healthy gingiva (Control group 1 (CG1), n = 22) and with gingivitis (Control group 2 (CG2), n = 23)

GM_CSF

14.5 (10.2–37.9)

16.8 (11.3–51.8)

0.522

15.1 (11.0-51.3)

25.3 (11.0-108.5)

0.763

IFNg

1.9 (1.7–2.2)

2.5 (2.0–7.0)

0.099

2.3 (1.8–3.5)

2.7 (2.0-20.8)

0.1565

IL2

15.7 (12.2–32.9)

16.0 (10.3–36.0)

0.683

17.8 (11.1–34.0)

14.5 (9.8–83.4)

0.881

IL6

21.1 (11.7–47.0)

10.0 (8.3–25.6)

0.027

10.4 (8.9–23.9)

10.0 (7.5–27.9)

0.084

IL7

15.5 (10.8–32.1)

18.1 (9.7–49.9)

0.982

16.8 (9.7–52.7)

18.1 (7.6–53.0)

0.943

IL8

4301 (2126–6997)^a

2176 (1546–3325)

0.037

1812 (881.6–2430)^a

2226 (1553–3502)

0.037

IL15

18.4 (13.5–33.4)

14.4 (11.0-34.7)

0.638

13.0 (11.4–26.4)

22.1 (10.8-126.2)

0.633

IP10

4.9 (4.2–5.2)

13.9 (4.2-181.7)

0.787

10.6 (4.1–89.3)

42.4 (4.2-260.2)

0.166

KC_like

461.7 (130.9-943.6)^a

155.9 (89.1-291.4)

0.014

130.9 (52.1-320.7)^a

178.4 (94.8-282.1)

0.036

IL10

13.8 (12.4–18.4)

13.8 (12.1–17.2)

0.787

13.5 (10.5–15.0)

14.5 (12.4–20.3)

0.469

IL18

11.1 (8.0-17.1)

10.8 (7.3–27.5)

0.764

8.3 (6.8–21.9)

13.7 (8.0-60.8)

0.253

MCP1

195.6 (138.9-432.2)^a

108.4 (91.8-133.2)

0.002

103.2 (94.8-119.5)^a

117.5 (91.8-212.6)

0.005

TNFα

14.3 (12.4–33.9)

14.3 (11.5–34.2)

0.638

12.9 (10.6–27.3)

18.2 (11.5–69.6)

0.581