Fig. 1

Schematic diagram of MrN-VLP constructs and deduced three dimensional structures of the modified N-termini of VLPs. A: linear stretches of MrNV capsid protein containing an inherent RNA-binding domain (RBD1, blue) at its N-terminus and the extended hexa-histidine residues at the end of C-terminus. Red boxed areas with crosses indicate deleted amino acids in which foremost area is replaced by the additional RNA-binding domain (RBD2, pink) or deca-arginine peptide (10R, green). B: predicted 3D ribbon models of chimeric MrN-VLPs containing capsid’s exterior, shell and capsid’s interior (left), the latter of which contains N-terminus amino acids which are modified by RBD (V1-MrNV) or 10R (V2-MrNV) (right)