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Table 1 Posterior median, 95% credible interval (CI95), and the deviance information criterion (DIC) for three conditional independent models and one conditional dependent model for the sensitivity (Se), specificity (Sp), and prevalence (prev) of three Mycoplasma bovis antibody ELISA tests (ID screen, Bio K302, Bio K432) on 156 bulk tank milk samples from Belgian (n = 85) and Swiss (n = 71) dairy herds. Manufacturer cutoff values for the sample-to-positive percentage (S/P%) were used. The first independent model (bold) was used for further Bayesian latent class modelling

From: Diagnostic performance of Mycoplasmopsis bovis antibody ELISA tests on bulk tank milk from dairy herds

  

INDEPENDENT

DEPENDENT

Testcutoff(S/P%)

Parameter

Model 1a

Model 2b

Model 3c

Model 3c

ID≥ 30%

Se (%) (CI95)

91.4 (70.7–99.7)

91.0 (70.7–99.6)

78.8 (64.4–92.7)

77.4 (54.1–93.5)

ID≥ 30%

Sp (%) (CI95)

67.2 (53.6–92.6)

68.3 (54.7–92.6)

71.9 (57.8–93.3)

69.3 (51.5–93.1)

K432≥ 40%

Se (%) (CI95)

25.6 (12.4–50.5)

24.7 12.3–46.3)

19.5 (10.5–32.4)

19.3 (10.1–32.6)

K432≥ 40%

Sp (%) (CI95)

96.8 (91.1–99.7)

96.9 (91.2–99.7)

97.2 (90.9–99.8)

96.9 (90.3–99.8)

K302≥ 37%

Se (%) (CI95)

69.2 (43.3–96.4)

67.4 (43.2–95.2)

63.2 (45.8–81.4)

63.4 (45.8–82.0)

K302≥ 37%

Sp (%) (CI95)

85.8 (74.8–97.4)

86.3 (75.6–97.5)

96.4 (92.4–98.7)

96.4 (92.3–98.8)

 

Prev (%) (CI95)

30.8 (14.4–56.1)

32.7 (17.4–55.0)

44.1 (30.0-61.9)

43.7 (29.4–62.1)

 

covDn (CI95)

-

 -

 -

0.00 (-0.02-0.03)

 

covDp (CI95)

-

 -

 -

0.01 (-0.06-0.13)

 

DIC model

37.34

37.05

38.49

39.68

  1. aModel 1: no informative priors
  2. bModel 2: informative prior on prevalence of M. bovis in Flanders and Switzerland (mode, 40%; 95th percentile 16%) resulting in prior density Beta(3.223,4.335)6,27,28
  3. cModel 3: informative prior on prevalence and Bio K302 sensitivity (mode 60.4%, 95th percentile 37.5%) and specificity (mode 97.3%, 95th percentile 94%) resulting in prior density Beta(8.086, 5.646) and Beta(147.175,5.056), respectively16