Table 2 KEGG pathway enrichment analysis of DEPs identified at 30 dpi and 45 dpi of MDV
From: Splenic proteome profiling in response to Marek’s disease virus strain GX0101 infection
KEGG pathway | Common proteins | Specific proteins | |
|---|---|---|---|
30 dpi specific proteins | 45 dpi specific proteins | ||
RIG-I-like receptor signaling pathway | IRF7/NFKB1/NLRX1/ IκBKB/ RELA / | TRIM25/MAVS/ ATG5 | |
NOD-like receptor signaling pathway | NFKB1/ IκBKB/ RELA / | FNIP1/MAPK1 | |
mTOR signaling pathway | IκBKB/MTOR/PIK3R2/ PDPK1/CAB39/RRAGC/ BRAF/ | PRKCA/RPS6KA1/ MAPK1 | PRKAA1/RICTOR/ |
Natural killer cell mediated cytotoxicity | PIK3R2/BRAF/ MAP2K1/PPP3R1/ VAV3/PAK1/ | PTPN11/LOC419429/ BF1/ MAPK1/ PRKCA/ | |
Jak-STAT signaling pathway | MTOR/PIK3R2/STAT1/ STAT3/ | STAT5B/STAM2/ PTPN11/ LOC419429/ | CNTFR/IFNLR1/ IL2RA/ |
MAPK signaling pathway | NFKB1/ IκBKB/ RELA / BRAF/MAP2K1/ PPP3R1/PAK1/CRK/ CRKL/RPS6KA5/ NFKB2/FLNB/FGF2/ | PLA2G4A/LAMTOR3/STMN1/ATF2/MAPK1/PRKCA/ RPS6KA1 | MAP2K6/ RRAS2/ RAP1B/ |
T cell receptor signaling pathway | NFKB1/ IκBKB/ RELA / PIK3R2/PDPK1/ MAP2K1/PPP3R1/ VAV3/PAK1/CBL/ CARD11/ | PRKCQ/MAPK1 | NFKBIE/ |
FoxO signaling pathway | IκBKB/PIK3R2/PDPK1/ BRAF/MAP2K1/STAT3/ | CAT/SGK3/ MAPK1 | PRKAA1/PCK2/ SOD2/ |
B cell receptor signaling pathway | NFKB1/ IκBKB/ RELA/PIK3R2/ MAP2K1/PPP3R1/VAV3/ CARD11/PIK3AP1/ | BTK/MAPK1 | NFKBIE/CD79B/ |
Pathways in cancer | NFKB1/ IκBKB/ RELA / MTOR/PIK3R2/BRAF/ STAT1/ MAP2K1/ STAT3/ CBL/ CRK/ CRKL/NFKB2/FGF2/ CTNNA2/HDAC2/ GNAQ/LAMB2/ LOC416354/JUP/ EDNRA/CCDC6/ TCF7L2/ | RASSF5/ FNIP1/ MAPK1/PRKCA/ STAT5B/ COL4A2/ TPM3/ ITGA3/GNG5/ARNT/SLC2A1 | GNAI2/ITGA2/ FN1/TCEB1/ APPL1/ |
VEGF signaling pathway | PIK3R2/MAP2K1/ PPP3R1/PXN/ | MAPK1/PRKCA/ PLA2G4A | |
ECM-receptor interaction | LAMB2/ITGB3/COL6A2/ COL6A3/COL1A2/ | COL4A2/ ITGA3/ CD44 | ITGA2/FN1/ THBS1/ |
Chemokine signaling pathway | NFKB1/ IκBKB/ RELA/ PIK3R2/BRAF/STAT1/ MAP2K1/VAV3/PAK1/ STAT3/CRK/CRKL/ PXN/DOCK2/ELMO1/ | MAPK1/STAT5B/ GNG5/WASL | GNAI2/RAP1B/ XCL1/ |
Apoptosis | NFKB1/ IκBKB/RELA / PIK3R2/PDPK1/ MAP2K1/TUBA1C/ AIFM1/BAK1/CAPN1/ | MAPK1/LMNB1/ LMNA/ | TUBA3E/CTSD/ DFFA/ |
MicroRNAs in cancer | NFKB1/ IκBKB/MTOR/ MAP2K1/STAT3/CRK/ CRKL/RPS6KA5/ ITGB3/ BAK1/DNMT1/ TPM1/ | PRKCA/STMN1/CD44 | THBS1/EZR/ |
cGMP-PKG signaling pathway | PIK3R2/MAP2K1/ PPP3R1/GNAQ/ EDNRA/SLC25A6/ ATP1B1/MYL9/ GUCY1A2/PRKG1/ | MAPK1/ATF2/SLC25A4/PPP1CB/ATP2B1 | ATP1A3/GNAI2/ |
PPAR signaling pathway pathway | PDPK1/CPT1A/FABP4/ ACSL1/ | ACAA1/ILK/CPT2 | PCK2/FABP7/ FABP5/ |
NF-kappa B signaling pathway | NFKB1/ IκBKB/RELA/ NFKB2/CARD11/ | TRIM25/ PRKCQ/ BTK | |
Calcium signaling pathway | PPP3R1/GNAQ/ EDNRA/SLC25A6/ STIM1/ | PRKCA/ SLC25A4/ ATP2B1 | P2RX1/ |
Ras signaling pathway | NFKB1/ IκBKB/RELA/ PIK3R2/MAP2K1/ PAK1/FGF2/EXOC2/ ARF6/ | MAPK1/ PRKCA/ PTPN11/ LOC419429/ PLA2G4A/ RASSF5/ GNG5 | RRAS2/RAP1B/ RAB5B/ |
Rap1 signaling pathway | PIK3R2/BRAF/ MAP2K1/CRK/CRKL/ FGF2/GNAQ/ITGB3/ | MAPK1/ PRKCA/ RASSF5/TLN2/ | MAP2K6/ GNAI2/ RAP1B/ THBS1/ |
PI3K-Akt signaling pathway | NFKB1/ IκBKB/RELA/ MTOR/PIK3R2/PDPK1/ MAP2K1/FGF2/ PIK3AP1/LAMB2/ ITGB3/COL6A2/ COL6A3/COL1A2/ YWHAQ/YWHAG/ | FNIP1/MAPK1 PRKCA/ATF2/SGK3/ COL4A2/ ITGA3/ GNG5 | PRKAA1/ PPP2R5C/ PCK2/ IL2RA/ ITGA2/ FN1/ THBS1/ |
Notch signaling pathway | HDAC2/LOC416354/ SNW1/ | PSEN1/ | |
cAMP signaling pathway | NFKB1/RELA/PIK3R2/ BRAF/MAP2K1/VAV3/ PAK1/EDNRA/ATP1B1/ MYL9/ | MAPK1/ PPP1CB/ ATP2B1 | RRAS2/ATP1A3/ GNAI2/RAP1B/ CNGA3/ |
AMPK signaling pathway | MTOR/PIK3R2/PDPK1/ CAB39/CPT1A/RAB8A/ PFKM/ | PRKAA1/PPP2R5C/RAB11B/PCK2/ | |
Hippo signaling pathway | CTNNA2/TCF7L2/ YWHAQ/YWHAG/ | PPP1CB | |
Wnt signaling pathway | PPP3R1/LOC416354/ TCF7L2/CSNK1A1/ | PRKCA | PSEN1/TBL1X/ |
Prion diseases | MAP2K1/PPP3R1/ HDAC2/GNAQ/CAPN1/ SLC25A6/C7/C6/ CLTC/AP2M1/ATP8/ COX4I1/NDUFB6/ DCTN2/AP2A2/HTT/ DCTN4/NRF1/POLR2F/ UBE2G1/UCHL1 | MAPK1/ SLC25A4/ COX7A2/ NDUFV1/ NDUFB3/ SEP-05 | SOD2/GNAI2/ PSEN1/NDUFA9/ NDUFB10/LRP1/ UBE2G2/CLTA/ TGM2/ POLR2L |
Fc epsilon RI signaling pathway | PIK3R2/PDPK1/ MAP2K1/VAV3/ | MAPK1/PRKCA/BTK/PLA2G4A | MAP2K6/ |
Regulation of autophagy | ATG7/ATG3/ATG4B/ ATG4B/ | ATG5 | PRKAA1/ |
TNF signaling pathway | NFKB1/ IκBKB/RELA/ PIK3R2/MAP2K1/ RPS6KA5/ | MAPK1/ATF2/ | MAP2K6/ |
Toll-like receptor signaling pathway | IRF7/NFKB1/ IκBKB/ RELA/PIK3R2/STAT1/ MAP2K1/ | MAPK1 | MAP2K6/ |
ErbB signaling pathway | MTOR/PIK3R2/ BRAF/ MAP2K1/PAK1/ CBL/CRK/CRKL/ | MAPK1/PRKCA/ STAT5B | |
TGF-beta signaling pathway | MAPK1/ E2F4 | ||