Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum

Wu, Qiu jue; Zhu, Long long; Zhang, Rong kai; Xing, Zhong ying; Wang, Cong; Liao, Jia hui; Hu, Nai zhi; Cheng, Bin yao; Ma, Yan; Wang, Yu qin

doi:10.1186/s12917-023-03836-5

Table 5 Effect of dietary Gln on main pattern recognition receptors in innate immune related signaling pathways and regulation of broiler chickens infected with Salmonella pullorum

From: Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum

Items^b	CON^a	Gln (%)^a		Scc^a	Gln^a (%) + S. pullorum		Mean	SEM	P-values^c
Items^b	CON^a	0.5	1.0	Scc^a	0.5	1.0	Mean	SEM	Stress	Diet	Interaction
d 4
NOD1	0.99	0.75	0.76	1.21	1.07	1.00	0.96	0.14	0.013	0.029	0.021
TLR2	0.78	0.50	0.47	1.20	0.93	0.80	0.78	0.10	0.011	0.031	0.013
TLR4	0.51	0.30	0.28	0.81	0.60	0.50	0.50	0.15	0.008	0.025	0.021
MDA5	1.11	0.85	0.88	0.85	1.10	1.12	0.99	0.16	< 0.001	0.001	0.011
DAI	1.00	0.37	0.38	1.88	1.14	1.10	0.99	0.12	0.005	0.015	0.023
LGP2	1.07	0.74	0.73	0.77	0.99	1.04	0.89	0.14	0.017	0.034	0.033
MAVS	0.27	0.10	0.08	0.77	0.37	0.30	0.32	0.12	0.024	0.017	0.037
d 7
NOD1	1.08	0.79	0.78	1.49	1.11	1.05	1.05	0.15	0.015	0.021	0.012
TLR2	0.84	0.58	0.59	1.31	1.04	0.96	0.89	0.13	0.017	0.027	0.014
TLR4	0.57	0.38	0.39	0.90	0.68	0.59	0.59	0.12	0.014	0.019	0.027
MDA5	1.20	0.92	0.97	0.91	1.13	1.19	1.05	0.14	0.021	0.041	0.020
DAI	1.07	0.42	0.41	1.97	1.21	1.17	1.04	0.17	0.019	0.021	0.027
LGP2	1.11	0.81	0.80	0.81	1.06	1.10	7.15	0.15	0.030	0.014	0.017
MAVS	0.28	0.12	0.11	0.81	0.39	0.32	0.34	0.16	0.023	0.009	0.014
d 14
NOD1	1.19	0.82	0.84	1.58	1.21	1.20	1.14	0.11	0.004	0.011	0.014
TLR2	0.87	0.63	0.60	1.39	1.10	1.04	0.94	0.12	0.041	0.031	0.043
TLR4	0.61	0.41	0.46	0.99	0.74	0.65	0.64	0.17	0.023	0.047	0.027
MDA5	1.28	0.99	0.99	0.97	1.24	1.28	1.13	0.13	0.029	0.035	0.040
DAI	1.12	0.50	0.51	2.04	1.30	1.24	0.92	0.18	0.030	0.024	0.017
LGP2	1.19	0.87	0.89	0.86	1.09	1.16	1.01	0.16	0.043	0.028	0.027
MAVS	0.31	0.19	0.20	0.88	0.42	0.37	0.40	0.15	0.018	0.018	0.025
d 21
NOD1	1.27	0.86	0.87	1.76	1.33	1.28	1.23	0.14	0.017	0.029	0.019
TLR2	0.93	0.69	0.67	1.43	1.17	1.18	1.01	0.10	0.028	0.009	0.041
TLR4	0.69	0.47	0.50	1.05	0.78	0.71	0.70	0.17	0.020	0.018	0.011
MDA5	1.54	1.04	1.09	1.01	1.49	1.42	1.26	0.16	0.028	0.041	0.018
DAI	1.20	0.58	0.56	2.18	1.55	1.30	1.23	0.18	0.018	0.034	0.017
LGP2	1.28	0.93	0.84	0.82	1.20	1.22	1.05	0.12	0.008	0.042	0.027
MAVS	0.37	0.24	0.22	0.94	0.50	0.43	0.45	0.14	0.019	0.027	0.024

^aGlutamine per kg standard diet feed: Con, 0% Gln, noninfect control treatment; 0.5%Gln = basal diet supplemented with 0.5% Gln; 1.0%Gln = basal diet supplemented with 1.0% Gln. Scc = Salmonella pullorum infect control treatment received the basal diet
^bNOD1 Nodinitib-1, TLR2 Toll-like receptors 2, TLR4 Toll-like receptors 2, MDA5 Melanoma differentiation-associated gene, DAI DNA-dependent activator of IFN-regulatory factors, LGP2 Laboratory of genetics and physiology gene 2, MAVS Mitochondrial antiviral-signaling protein
^cThe P-values represent the main effect of the diet, the main effect of Salmonella pullorum challenge, and the interaction between the dietary treatments and Salmonella pullorum challenge

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