Morphologic, phenotypic, and genotypic similarities between primary tumors and corresponding 3D cell cultures grown in a repeatable system—preliminary results

Table 3 NGS data of primary tumors and 3D cell cultures from carcinoma samples

Case	Specimen	TP53	MDM2	Mean coverage (reads per amplicon)	Mean coverage MDM2	Mean coverage TP53	Ratio (MDM2/TP53)
1	Primary Tumor	WT	WT	1190	1446	863	1.37
1	3D cell culture	WT	WT	483	494	468	1.03
2	Primary Tumor	WT	WT	30	15	49	0.61
2	3D cell culture	WT	WT	72	72	72	1.0
3	Primary Tumor	WT	WT	591	595	585	1.0
3	3D cell culture	WT	WT	340	367	306	1.1
4	Primary Tumor	NE	NE	/	/	/	/
4	3D cell culture	NE	NE	/	/	/	/

ISSN: 1746-6148