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Table 1 Immunomorphological comparison between primary tumors and 3D cell cultures

From: Morphologic, phenotypic, and genotypic similarities between primary tumors and corresponding 3D cell cultures grown in a repeatable system—preliminary results

ID

Anatomic site

Histological diagnosis

3D cell culture cellularity

scoring (1–5)

Primary tumor

immunophenotype

3D cell culture immunophenotype

1

Lung

Papillary carcinoma

2

Panck + TTF1+

Panck + TTF1+

2

Lung

Squamous carcinoma with papillary and lepidic differentiation

2

Panck + TTF1+

Panck + TTF1+

3

Skin

Epitheliomatous sebaceous carcinoma

4

Panck+

Panck+

4

Thyroid gland

Follicular-compact carcinoma

4

Panck + TTF1+

Panck + TTF1+

5

Skin

Perivascular wall tumor

3

Vim + act- calp-

Vim + act- calp-

6

Skin

Perivascular wall tumor

3

Vim + act + calp-

Vim + act- calp-

7

Skin

Perivascular wall tumor

5

Vim + act- calp-

Vim + act- calp-

  1. vim = vimentin; act = actin; calp = calponin; panck = pancytokeratin