Table 6 Mean (± SD) pharmacokinetic parameters of BCL from study two after p.o. AMO-RSE powder at doses of 5, 10 and 15 mg/kg BCL in pigs (n = 6)

λ_z (1/h)

0.14

0.05

0.09

0.01

0.10

0.02

t_1/2λ (h)

5.70

1.89

7.65

1.23

7.57

2.00

AUC_0-∞ (µg·h/mL)

5.96

1.33

9.91

1.94

15.08

3.94

AUMC_0-∞ (µg·h²/mL)

52.95

22.27

102.09

34.84

155.79

72.72

MRT_0-∞ (h)

8.67

2.23

10.11

1.67

9.92

2.06

C_max (µg/mL)

0.64

0.25

1.92

0.66

1.79

0.34

T_max (h)

Median

Range

Median

Range

Median

Range

2.00

0.75–3.00

2.00

1.00–3.00

2.00

1.50–2.00