Table 3 Comparison of plasma AMO pharmacokinetic parameters after single-dose oral administration of AMO-RSE powder and AMO powder (AMO 10 mg/kg) (n = 6)

λ_z (1/h)

0.1843

0.1313

0.2087

0.1001

0.726

t_1/2λ (h)

6.0402

3.9833

3.9712

1.7612

0.283

AUC_0-∞ (µg·h/mL)

4.1215

0.9592

4.3558

1.6442

0.771

AUMC_0-∞ (µg·h²/mL)

34.2215

21.1752

27.9650

20.7409

0.616

MRT_0-∞ (h)

7.9894

4.3668

5.8845

2.0788

0.321

C_max (µg/mL)

0.9443

0.2510

0.9205

0.1433

0.845

T_max (h)

Median

Range

Median

Range

1.5833

1.00 ~ 2.00

1.2500

1.00 ~ 1.50

0.186