Table 1 Comparison between peripheral (plasma and saliva) and central oxytocin concentrations (cerebrospinal fluid) (CSF: cerebrospinal fluid; EIA: enzyme immunoassay; RIA: radioimmunoassay)

Plasma and CSF

-0.149 (p = 0.352)

Human

Basal conditions

RIA

[52]

Plasma and CSF

0.00 (P = 0.99) (RIA)

0.48 (P = 0.02) (EIA)

0.80 (P < 0.01) (EIA)

0.59 (P = 0.04) (EIA)

Human and non-human primates

During surgery (human) and awake and anesthetized animals (non-human primates)

EIA (Enzo Life Sciences)

RIA

[57]

Plasma, saliva and CSF

Saliva-CSF:

0.657 (P < 0.001)

Saliva-Plasma:

0.361 (P = 0.010)

Plasma-CSF:

0.417 (P = 0.003)

Human

Patients in neurocritical care

RIA

[51]

Saliva and plasma

-0.26 (P = 0.43)

Human

After intranasal oxytocin administration

EIA (Enzo Life Sciences)

[33]

Plasma and CSF

0.10 (P = 0.714)

Human

After intranasal oxytocin administration

RIA

[58]

Plasma and CSF

0.56 (P = 0.006)

Human

Anxiety

EIA (Enzo Life Sciences)

[59]

Saliva and plasma

0.59 (P = 0.022)

Human

Breats-feeding mothers

EIA (Assay Designs)

[55]

Saliva and plasma

0.252 (P = 0.180)

Human

Healthy young men

EIA (LUCIO- Medical ELISA Oxytocin)

[53]

Plasma and CSF

0.926 (P < 0.001)

Human

Headache

RIA

[60]

Plasma, saliva and CSF

Saliva-CSF:

0.624 (P < 0.001)

Plasma-CSF:

0.407 (P < 0.001)

Human

Postpartum depression

EIA (Nanjing SenBeiJia Biologic Technology Co.)

[61]

Saliva and plasma

0.32 (P < 0.01)

Human

Depressive symptomatology

EIA (Assay Designs)

[62]

Saliva and plasma

0.41 (P < 0.001)

Human

Parents interaction with infants

EIA (Assay Designs)

[56]

Plasma and CSF

No significant

Human

Suicide attempters

RIA

[47]

Amygdala/Hippocampus and plasma

0.771 (P = 0.072)

0.600 (P = 0.208)

-0.030 (P = 0.934)

-0.029 (P = 0.957)

Rat and mice

After intranasal and peripheral oxytocin administration

RIA

[63]

Hypothalamic and serum

0.010 (P = 0.967)

0.596 (P = 0.006)

0.542 (P = 0.016)

Rat

Mother-pup interaction

EIA (Assay Designs)

[64]