Table 3 Productivity comparison between CelCradle and BioFactory in producing the PRRS vaccine
Production system | Working units per total virus production of 1.02 × 1011 TCID50 | Total virus production (1011 TCID50) | Total spent medium (L) | Total process time (d) | Culture medium productivity (109 TCID50/L/d)a | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Cell inoculum preparation | Cell culture phase | Viral culture phase | Total | Cell inoculum preparation | Cell culture phase | Viral culture phase | Total | ||||
CelCradle (Lot D) | 1 | 1.02 | 0.00 | 1.25 | 1.00 | 2.25 | 0 | 5 | 2 | 7 | 6.48 |
BioFactory (1-layer) | 10 | 1.02 | 0.35 | 1.50 | 1.25 | 3.10 | 4 | 4 | 2 | 10 | 3.29 |