Fig. 4

Results of animal experiment: protective efficacy of CelCradle-produced vaccine under experimental conditions. A total of 8 3-week-old pigs were randomly divided into two groups of four each. Group 1 was immunized intramuscularly (IM) with CelCradle-produced K418DM1.1 (10^4.5 TCID₅₀/1 mL/dose), whereas group 2 remained unvaccinated. At 42 days post immunization, both groups were challenged IM with homologous strain, LMY (10^5.0 TCID₅₀/1 mL/dose). (A) Neutralizing antibody titer measured against the challenge strain, LMY. Asterisks indicate significant (p ≤ 0.05) differences between the groups. Horizontal dotted line represents the cutoff value of the test. (B) Level of viremia measured by titration. Asterisks indicate significant (p ≤ 0.05) differences between the groups