Table 2 Receiver operating characteristic (ROC) curve analysis for determination of cutoff value for the salivary analytes investigated in pigs with meningitis
Area under the ROC curve (AUC) | 95% CI | P values | Cutoff value | Sensitivity (%) | |
|---|---|---|---|---|---|
Stress | |||||
Alpha-amylase (U/L) | 0.96 | 0.96-1 | < 0.001 | 2224 | 95.24 |
Cortisol (ng/mL) | 0.71 | 0.53–0.88 | 0.03 | 46.40 | 81.25 |
Oxytocin (pg/mL) | 0.79 | 0.64–0.95 | 0.005 | 2071 | 89.47 |
Inflammation | |||||
Haptoglobin (mg/L) | 0.69 | 0.52–0.86 | 0.02 | 2.50 | 72.73 |
ITIH4 (µg/L) | 0.73 | 0.56–0.91 | 0.023 | 21.23 | 68.75 |
Total proteins (mg/dL) | 0.92 | 0.81-1 | 0.002 | 199 | 83.33 |
S1000A8-A9 (mg/L) | 0.89 | 0.69–0.96 | < 0.001 | 0.175 | 85 |
S100A12 (mg/mL) | 0.88 | 0.77–0.99 | < 0.001 | 491.2 | 83.33 |
Redox status | |||||
FRAS (µmol/L) | 0.58 | 0.33–0.84 | 0.49 | 0.26 | 62.5 |
AOPP (µmol/L) | 0.76 | 0.52-1 | 0.04 | 118.5 | 87.5 |
Muscle damage | |||||
Creatine kinase (U/L) | 0.73 | 0.57–0.89 | 0.012 | 98.55 | 77.78 |
Creatine kinase – myocardial band (ng/mL) | 0.77 | 0.56–0.99 | 0.027 | 50.60 | 70 |
Troponin I (ng/mL) | 0.68 | 0.52–0.84 | 0.029 | 0.207 | 75 |
Lactate (mmol/L) | 0.69 | 0.51–0.87 | 0.042 | 10.50 | 70.59 |
Lactate dehydrogenase (µkat/L) | 0.87 | 0.76–0.98 | 0.001 | 55.15 | 82.35 |
Aspartate aminotransferase (U/L) | 0.84 | 0.72–0.97 | 0.003 | 160.7 | 81.25 |
Alanine aminotransferase (U/L) | 0.78 | 0.59–0.98 | 0.023 | 17.85 | 88.89 |
Sepsis | |||||
Procalcitonin (ng/mL) | 0.86 | 0.64–0.96 | 0.01 | 2940 | 75 |
Aldolase (U/L) | 0.79 | 0.62–0.97 | 0.014 | 18.35 | 88.89 |
Immune system | |||||
Adenosine deaminase (U/L) | 0.92 | 0.87-1 | < 0.001 | 7680 | 92.96 |