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Fig. 4 | BMC Veterinary Research

Fig. 4

From: Nigella sativa-chitosan nanoparticles: Novel intestinal mucosal immunomodulator controls and protects against Salmonella enterica serovar Enteritidis infection in broilers

Fig. 4

Histopathological changes in the cecum, ileum and liver of CNP-NS non-supplemented (A), and CNP-NS-supplemented chicks (B) at 7 days post challenge with S. Enteriditis. Sections of cecum, ileum and liver collected from CNP-NS non-supplemented chicks post challenge showed characteristic cecal mucosal damage (blue arrow), marked inflammatory cellular infiltration (IFC, orange star). Ileal villous desquamation (yellow star), glandular and crypt destruction (red star) and influx of inflammatory cells (IFC, orange star). Liver with focal necrosis and replacement of necrotic cells by mixed inflammatory cellular aggregates (MIFC, light blue star). Meanwhile sections of cecum, ileum, and liver of the CNP-NS supplemented and then challenged chicks showed cecal immune-reactive lympho-follicular reaction (LF, black star). The ileal payer's patches (LF, lymphoid follicles) contained immune-reactive changes (black star). The liver revealed hepatocellular (blue star) and central vein structures. Stain H&E, Scale bars 50, 100 μm

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BMC Veterinary Research

ISSN: 1746-6148

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