Table 2 Pharmacokinetic parameters of florfenicol after a single intravenous injection of florfenicol solution, oral administration of FSRGs in fasted and fed condition at a dosage of 20 mg/kg b.w. in swine. Data value were expressed as mean ± SD (n = 8)

AUC_0-∞(h??g/ml)

114.97 ± 12.90

128.32 ± 28.07

100.98 ± 15.03*

K_el(1/h)

0.21 ± 0.031

0.16 ± 0.066

0.209 ± 0.063

T_1/2β(h)

3.32 ± 0.50

5.23 ± 3.37

3.54 ± 0.88

MRT(h)

4.52 ± 0.48

8.50 ± 1.16

7.35 ± 0.76*

C_max(µg/ml)

-

12.06 ± 1.94

12.49 ± 1.16

Cl(L/h/kg)

0.18 ± 0.020

-

-

V_d(L/kg)

0.84 ± 0.095

-

-

F(%)

-

~ 100%

87.83% ± 13.08

Median

Range

Median

Range

T_max(h)

-

4.25

3.00–6.00

3.50

3.00–4.00