Florfenicol sustained-release granules: an in vitro-in vivo correlation study in pigs

BMC Veterinary Research

Table 1 Fitting results of florfenicol release from FSRG

Dissolution media	Release kinetics model	Fitting equation	Coefficient of determination (r²)
pH1.2 HCl	Zero-order	\(Q=17.156t\)	0.7532
	First-order	\(\ln (100 - Q)= - 0.262t\)	0.9240
	Higuchi	\(Q{\text{=}}29.491{t^{1/2}}\)	0.9862
pH 4.3 acetate buffer	Zero-order	\(Q=13.952t\)	0.5124
	First-order	\(\ln (100 - Q)= - 0.344t\)	0.9508
	Higuchi	\(Q{\text{=}}34.095{t^{1/2}}\)	0.9775

Zero order(\(Q={k_0}t\)), first order(\(\ln (100 - Q)={k_1}t\)), Higuchi(\(Q{\text{=}}{k_H}{t^{1/2}}\))

ISSN: 1746-6148