Fig. 7
From: Mesenchymal stromal cells modulate infection and inflammation in the uterus and mammary gland
Bovine MSC elicits inflammatory response in the mouse mammary gland. Lactating mice were challenged by intramammary (IMM) infusion of LPS (A-B) or bMSC (C-D). Representative fluorescent microscopy images of mammary tissues 24 h after IMM infusion stained with DAPI (blue), phalloidin (red) and anti mouse CD45 antibodies (green). Inflammatory response in LPS-treated glands is characterized by massive recruitment of blood neutrophils into alveoli and milk ducts (white arrows in A-B), while neutrophil recruitment after bMSC treatment is restricted to the parenchyma surrounding the alveoli (white arrows in C-D) and were not visible in the alvolar milk space. Scale bars; 50 µm (A-C), 20 µm (D)