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Table 8 The Formulations Systems and Major Excipients of the Selected Commercial COE Products

From: Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products

Product No

Product name

Formulation system

Major ingredients in the formulation

Reference

1

Surolan

Nonaqueous system

silica colloidal anhydrous and liquid paraffin

Summary of product characteristics (Elanco Europe Ltd)

2

Dermotic

Nonaqueous system

paraffin oils and paraffin wax

Summary of product characteristics (Troy Laboratories Pty Ltd)

3

Mometamax

Nonaqueous system

mineral oil

polyethylene

Product material safety data (Intervet Inc.)

4

Easotic

Nonaqueous system

liquid paraffin

Summary of product characteristics (Virbac)

5

Canaural

Nonaqueous system

sesame oil

Summary of product characteristics (Dechra)

6

Osurnia

Nonaqueous system

butylhydroxytoluene (e 321)

hypromellose

lecithin

oleic acid

propylene carbonate

glycerol formal

Summary of product characteristics (Elanco Europe Ltd)

7

Baytril Otic

emulsion system

benzyl alcohol

cetylstearyl alcohol

a neutral oil

purified water emulsion

Product description (Bayer HealthCare LLC)

8

Aurizon Ear Drops

Nonaqueous system

propyl gallate (e310),

sorbitan oleate

silica, colloidal hydrophobic

triglycerides, medium-chain

Summary of product characteristics

(Vetoquinol UK Limited)

9

Apex PMP

Nonaqueous systema

-

Product material safety data sheet (Apex Laboratories Pty Ltd),

  1. a Assumption made based on the formulation density (0.84 – 0.89 g/mL)