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Table 4 Urine isoflupredone concentrations following a single intra-articular administration of 8 mg of isoflupredone acetate (Predef® 2X) in the right antebrachiocarpal joint 12 h post intra-articular LPS administration to exercised Thoroughbred horses (n = 8)

From: Pharmacokinetics and pharmacodynamics of intra-articular isoflupredone following administration to horses with lipopolysaccharide-induced synovitis

Time

Horse 1

Horse 2

Horse 3

Horse 4

Horse 5

Horse 6

Horse 7

Horse 8

 

Isoflupredone Concentration (ng/mL)

0 h

ND

ND

ND

ND

ND

ND

ND

ND

24 h

–-

6.40

ND

3.32

2.48

1.71

5.24

1.78

48 h

  

ND

 < LOQ

 < LOQ

 < LOQ

0.28

 < LOQ

72 h

ND

ND

ND

ND

ND

ND

ND

ND

  1. ND, not detected; –-, no sample