Fig. 3

Illustrative photomicrograph of colon of the negative control rat. a showing normal and intact colonic wall that is mainly consisted of normal tunica mucosa (arrow) having folds of tubular glands or crypts lined by columnar epithelium rich with goblet cells, submucosa of highly vascularized connective tissue (dashed arrow), well-defined muscularis (M) and serosa (arrow head). b-f Colon of positive control rat treated with DSS, b) showing sever degenerations of the covering epithelium (arrow), noticeable diffuse leukocytic infiltration extending in between the mucosa and submucosa (inset box). c Higher magnification of fig b inset box showing the diffuse leukocytic infiltration (arrow head). d,e showing sever desquamations of the covering epithelium (arrow) and degenerations of the gland lining epithelium (arrow head). f showing sever vascular dilatation with congestion in the inter glandular areas and hemosidriosis (arrow). Stain: Haematoxylin & Eosin (H&E). Scale bars: a,b,d = 900 μm; c,e = 300 μm; f = 40 μm