Designing multi-epitope-based vaccine targeting surface immunogenic protein of Streptococcus agalactiae using immunoinformatics to control mastitis in dairy cattle

Pathak, Rajesh Kumar; Lim, Byeonghwi; Kim, Do-Young; Kim, Jun-Mo

doi:10.1186/s12917-022-03432-z

Table 1 List of the selected cytotoxic T-lymphocyte (CTL) epitopes and their interacting BoLA class-I alleles with binding information

From: Designing multi-epitope-based vaccine targeting surface immunogenic protein of Streptococcus agalactiae using immunoinformatics to control mastitis in dairy cattle

S.N	MHC-I epitopes	Position	Antigenicity	Binding alleles	Prediction score	% Rank
1	GLQPHVAAY	323–331	1.4739	BoLA-2:06,201	0.585	0.06
				BoLA-1:00,901	0.819	0.07
				BoLA-T5	0.533	0.08
				BoLA-1:00,902	0.533	0.08
				BoLA-2:06,901	0.186	0.13
				BoLA-1:03,101	0.404	0.15
				BoLA-D18.4	0.650	0.18
				BoLA-1:02,301	0.650	0.18
				BoLA-4:02,402	0.619	0.18
				BoLA-1:03,102	0.272	0.19
				BoLA-4:02,401	0.401	0.29
				BoLA-2:05,501	0.190	0.33
				BoLA-2:00,802	0.214	0.36
				BoLA-2:04,401	0.379	0.39
				BoLA-2:06,001	0.111	0.40
				BoLA-2:00,801	0.303	0.45
				BoLA-2:04,402	0.176	0.45
2	NKSSYTVKY	49–57	1.3394	BoLA-D18.4	0.688	0.15
				BoLA-T5	0.519	0.09
				BoLA-1:00,902	0.519	0.09
				BoLA-1:02,301	0.688	0.15
				BoLA-1:03,101	0.330	0.26
				BoLA-1:03,102	0.222	0.32
				BoLA-1:04,201	0.301	0.21
				BoLA-2:02,201	0.255	0.10
				BoLA-2:04,301	0.262	0.09
				BoLA-2:04,601	0.223	0.32
				BoLA-2:04,801	0.559	0.13
				BoLA-2:05,501	0.498	0.01
				BoLA-2:06,201	0.373	0.33
				BoLA-2:06,901	0.138	0.29
				BoLA-3:03,701	0.529	0.04
				BoLA-3:05,101	0.186	0.29
3	SVADQKVSL	132–140	1.0980	BoLA-HD6	0.378	0.77
				BoLA-JSP.1	0.271	0.76
				BoLA-T2c	0.981	0.01
				BoLA-T7	0.555	0.00
				BoLA-1:02,801	0.154	0.36
				BoLA-1:06,101	0.464	0.05
				BoLA-1:06,701	0.531	0.10
				BoLA-2:00,501	0.438	0.06
				BoLA-2:00,601	0.138	0.38
				BoLA-2:00,602	0.164	0.41
				BoLA-2:01,602	0.138	0.38
				BoLA-2:03,001	0.213	0.06
				BoLA-2:04,701	0.201	0.45
				BoLA-2:05,401	0.081	0.05
				BoLA-2:05,601	0.179	0.12
				BoLA-2:05,701	0.509	0.05
				BoLA-2:06,001	0.130	0.29
				BoLA-2:06,901	0.156	0.23
				BoLA-2:07,001	0.192	0.25
				BoLA-3:00,102	0.067	0.33
				BoLA-3:00,103	0.146	0.12
				BoLA-3:01,001	0.284	0.10
				BoLA-3:03,501	0.037	0.32
				BoLA-3:03,601	0.514	0.02
				BoLA-3:03,801	0.268	0.07
				BoLA-3:05,002	0.211	0.40
				BoLA-3:05,201	0.418	0.04
				BoLA-3:06,501	0.427	0.37
				BoLA-3:06,601	0.526	0.04
				BoLA-3:06,602	0.504	0.06
				BoLA-3:06,801	0.464	0.05
				BoLA-3:07,301	0.473	0.01
				BoLA-4:06,301	0.260	0.08
				BoLA-5:00,301	0.454	0.12
				BoLA-5:03,901	0.197	0.14
				BoLA-5:06,401	0.195	0.05
				BoLA-5:07,201	0.321	0.04
				BoLA-6:01,501	0.119	0.26
				BoLA-6:01,502	0.075	0.27
4	TGASPEHV	260–267	1.0130	BoLA-3:01,701	0.595	0.04
				BoLA-3:01,702	0.540	0.02
				BoLA-3:01,703	0.527	0.04
5	SQAAANEQV	181–189	1.0004	BoLA-1:02,101	0.033	0.39
				BoLA-1:02,801	0.231	0.18
				BoLA-1:06,101	0.546	0.03
				BoLA-1:07,401	0.128	0.39
				BoLA-2:05,401	0.029	0.46
				BoLA-5:00,301	0.335	0.44

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