Table 1 BCR repertoires data using high-throughput sequencing in this study

Total reads

1,345,576

1,682,460

1,288,004

Merge reads

1,186,265

1,514,862

1,167,608

Filter reads

1,155,105

1,478,122

1,137,603

Clean reads

1,149,268

1,464,064

1,110,979

Unknown sequences numebr

5837

14,058

26,624

Productive sequences number

1,110,322

1,412,649

1,070,685

Non-productive sequences number

38,946

51,415

40,294

In-frame sequences number

1,138,293

1,447,833

1,098,274

Out-of frame sequences number

10,507

15,295

11,381

Total CDR3 sequences number

1,103,181

1,402,968

1,063,551

Unique CDR3 nt sequences number

278,712

261,800

240,260

Unique CDR3 aa sequences number

241,355

226,182

210,200