Skip to main content

Table 3 Fecal metabolomics summary

From: Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea

Metabolite Classification MANOVA P-value Change vs Baseline
Alkaloids 0.01b Mixed
Amino acids 0.0008a Decreased
Benzoate metabolism 0.03b Mixed
Carbohydrates 0.002a Mixed
Collagen metabolism 0.02a Decreased
Dipeptides 0.001a Decreased
Endocannabinoids 0.02a Decreased
Free Fatty Acids Polyunsaturated n3 0.02b Mixed
Polyunsaturated n6 0.02a Decreased
Saturated & Monounsaturated 0.06a Decreased
Hemoglobin metabolism 0.06a Decreased
Linolenate metabolism 0.03c Increased
Monoacylglycerols 0.04a Mixed
Phenolics 0.08a Mixed
Phospholipids Lysophospholipids ns  
Phosphatidylcholines (PC) 0.001b Decreased
Phosphatidylethanolamines (PE) ns  
Phospholipid metabolism ns  
Polyamines 0.03a Decreased
Postbiotics 0.02b Mixed
Primary bile acids 0.06a Decreased
Secondary bile acids ns  
Sphingolipids All 0.08a Decreased
Ceramides 0.09a Decreased
Dihydroceramides 0.01a Decreased
Dihydrosphingomyelins 0.04a Decreased
Hexosylceramides (HCER) 0.02a Decreased
Sphingolipid synthesis 0.02a Decreased
Sphingosines ns  
Sphingomyelins 0.009a Decreased
Terpenoids 0.0004a Increased
Tocopherol metabolism 0.04b Mixed
Tryptophan metabolism Indole pathway 0.0003a Mixed
Kynurenine pathway ns  
Serotonin pathway 0.048a Decreased
  1. aLinear trend over days, bquadratic trend over days, ccubic trend over days, ns = not significant; mixed directionality varied depending upon the metabolite in the group