Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea

Fritsch, Dale A.; Jackson, Matthew I.; Wernimont, Susan M.; Feld, Geoffrey K.; MacLeay, Jennifer M.; Brejda, John J.; Cochrane, Chun-Yen; Gross, Kathy L.

doi:10.1186/s12917-022-03315-3

Table 2 Significant Day 2 and 3 effects in selected PICRUSt-predicted functional pathways

From: Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea

Study day	Value*	FDR corrected P value	KEGG orthology (KO) group	Enzyme Commision (EC) number	Pathway	Specific pathways
2	−1.351	0.0109	K00023	acetoacetyl-CoA reductase [EC:1.1.1.36]	Carbohydrate	Glyoxylate and dicarboxylate, butanoate
2	−0.717	0.0386	K00169	pyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.1]	Carbohydrate	Butanoate, propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
					Energy	Carbon fixation pathways in prokaryotes, methane
					Xenobiotics	Nitrotoluene degradation
2	−0.734	0.0359	K00170	pyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.1]	Carbohydrate	Butanoate, propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
					Energy	Carbon fixation pathways in prokaryotes, methane
					Xenobiotics	Nitrotoluene degradation
2	−0.717	0.0386	K00172	pyruvate ferredoxin oxidoreductase, gamma subunit [EC:1.2.7.1]	Carbohydrate	Butanoate, Propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
					Energy	Carbon fixation pathways in prokaryotes, methane
					Xenobiotics	Nitrotoluene degradation
2	−0.631	0.0273	K01426	amidase [EC:3.5.1.4]	Amino acids	Phenylalanine, arginine and proline, tryptophan
					Other amino acids	Cyanoamino acid
					Xenobiotics	Styrene and aminobenzoate degradation
2	−1.164	0.0314	K01617	4-oxalocrotonate decarboxylase [EC:4.1.1.77]	Xenobiotics	Xylene, dioxin, and benzoate degradation
2	−1.247	0.0109	K01907	acetoacetyl-CoA synthetase [EC:6.2.1.16]	Carbohydrate	Butanoate
2	−1.247	0.0109	K01907	acetoacetyl-CoA synthetase [EC:6.2.1.16]	Lipid	Lipid biosynthesis proteins
2	−1.144	0.0034	K01908	propionyl-CoA synthetase [EC:6.2.1.17]	Carbohydrate	Propanoate
2	−1.144	0.0034	K01908	propionyl-CoA synthetase [EC:6.2.1.17]	Lipid	Lipid biosynthesis proteins
2	0.126	0.0301	K01963	acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2]	Carbohydrate	Propanoate, pyruvate
					Lipid	Fatty acid biosynthesis
					Energy	Carbon fixation pathways in prokaryotes
					Terpenoids and polyketides	Tetracycline biosynthesis
2	0.151	0.0175	K04072	acetaldehyde dehydrogenase/alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]	Carbohydrate	Butanoate, pyruvate, glycolysis/gluconeogenesis
					Lipid	Fatty acid biosynthesis
					Xenobiotics	Xylene, dioxin, naphthalene, benzoate, chloroalkane and chloroalkene degradation
					Amino acids	Tyrosine
2	−1.302	0.0204	K07516	3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]	Lipid	Fatty acid biosynthesis
2	−1.302	0.0204	K07516	3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]	Energy	Carbon fixation pathways in prokaryotes
3	−1.415	0.0071	K00023	acetoacetyl-CoA reductase [EC:1.1.1.36]	Carbohydrate	Butanoate, glyoxylate and dicarboxylate
3	−1.017	0.0343	K00451	homogentisate 1,2-dioxygenase [EC:1.13.11.5]	Amino acids	Tyrosine
3	−1.017	0.0343	K00451	homogentisate 1,2-dioxygenase [EC:1.13.11.5]	Xenobiotics	Styrene degradation
3	−0.709	0.0107	K01426	amidase [EC:3.5.1.4]	Amino acids	Phenylalanine, arginine and proline, tryptophan
					Other amino acids	Cyanoamino acid
					Xenobiotics	Styrene and aminobenzoate degradation
3	−0.728	0.042	K01580	glutamate decarboxylase [EC:4.1.1.15]	Carbohydrate	Butanoate
					Amino acids	Alanine, aspartate and glutamate metabolism
					Other amino acids	beta-alanine, taurine and hypotaurine
					Metabolic diseases^h	Type 1 diabetes mellitus
3	−0.833	0.0264	K01692	enoyl-CoA hydratase [EC:4.2.1.17]	Carbohydrate	Butanoate, propanoate
					Lipid	Fatty acid biosynthesis
					Amino acids	Tryptophan and/lysine, valine, leucine and isoleucine degradation
					Other amino acids	beta-alanine
					Terpenoids and Polyketides	Geraniol, limonene and pinene degradation
					Xenobiotics	Aminobenzoate, benzoate, and caprolactam degradation
3	−1.218	0.0134	K01907	acetoacetyl-CoA synthetase [EC:6.2.1.16]	Carbohydrate	Butanoate
3	−1.218	0.0134	K01907	acetoacetyl-CoA synthetase [EC:6.2.1.16]	Lipid	Fatty acid biosynthesis
3	0.122	0.0377	K01963	acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2]	Carbohydrate	Propanoate
					Energy	Carbon fixation pathways in prokaryotes, methane
					Lipid	Fatty acid biosynthesis
					Terpenoids and polyketides	Tetracycline biosynthesis
3	−0.667	0.0386	K03781	catalase [EC:1.11.1.6]	Neurodegenerative^h	Amyotrophic lateral sclerosis
					Transport and catabolism^c	Peroxisome
					Amino acids	Tryptophan
					Energy	Methane
3	−1.219	0.0331	K07516	3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]	Energy	Carbon fixation pathways in prokaryotes, methane
3	−1.219	0.0331	K07516	3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]	Lipid	Fatty acid biosynthesis

*Values are the estimated log ratios of relative pathway abundances between the respective Day and Day 1. All pathways were designated as metabolic pathways unless otherwise designated by superscript: c = cellular processes, h = human disease

Back to article page

ISSN: 1746-6148

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Veterinary Research

Contact us