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Table 2 Significant Day 2 and 3 effects in selected PICRUSt-predicted functional pathways

From: Microbiome function underpins the efficacy of a fiber-supplemented dietary intervention in dogs with chronic large bowel diarrhea

Study day Value* FDR corrected P value KEGG orthology (KO) group Enzyme Commision (EC) number Pathway Specific pathways
2 −1.351 0.0109 K00023 acetoacetyl-CoA reductase [EC:1.1.1.36] Carbohydrate Glyoxylate and dicarboxylate, butanoate
2 −0.717 0.0386 K00169 pyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.1] Carbohydrate Butanoate, propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
Energy Carbon fixation pathways in prokaryotes, methane
Xenobiotics Nitrotoluene degradation
2 −0.734 0.0359 K00170 pyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.1] Carbohydrate Butanoate, propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
Energy Carbon fixation pathways in prokaryotes, methane
Xenobiotics Nitrotoluene degradation
2 −0.717 0.0386 K00172 pyruvate ferredoxin oxidoreductase, gamma subunit [EC:1.2.7.1] Carbohydrate Butanoate, Propanoate, citrate cycle (TCA), glycolysis/gluconeogenesis, pyruvate
Energy Carbon fixation pathways in prokaryotes, methane
Xenobiotics Nitrotoluene degradation
2 −0.631 0.0273 K01426 amidase [EC:3.5.1.4] Amino acids Phenylalanine, arginine and proline, tryptophan
Other amino acids Cyanoamino acid
Xenobiotics Styrene and aminobenzoate degradation
2 −1.164 0.0314 K01617 4-oxalocrotonate decarboxylase [EC:4.1.1.77] Xenobiotics Xylene, dioxin, and benzoate degradation
2 −1.247 0.0109 K01907 acetoacetyl-CoA synthetase [EC:6.2.1.16] Carbohydrate Butanoate
Lipid Lipid biosynthesis proteins
2 −1.144 0.0034 K01908 propionyl-CoA synthetase [EC:6.2.1.17] Carbohydrate Propanoate
Lipid Lipid biosynthesis proteins
2 0.126 0.0301 K01963 acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2] Carbohydrate Propanoate, pyruvate
Lipid Fatty acid biosynthesis
Energy Carbon fixation pathways in prokaryotes
Terpenoids and polyketides Tetracycline biosynthesis
2 0.151 0.0175 K04072 acetaldehyde dehydrogenase/alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] Carbohydrate Butanoate, pyruvate, glycolysis/gluconeogenesis
Lipid Fatty acid biosynthesis
Xenobiotics Xylene, dioxin, naphthalene, benzoate, chloroalkane and chloroalkene degradation
Amino acids Tyrosine
2 −1.302 0.0204 K07516 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] Lipid Fatty acid biosynthesis
Energy Carbon fixation pathways in prokaryotes
3 −1.415 0.0071 K00023 acetoacetyl-CoA reductase [EC:1.1.1.36] Carbohydrate Butanoate, glyoxylate and dicarboxylate
3 −1.017 0.0343 K00451 homogentisate 1,2-dioxygenase [EC:1.13.11.5] Amino acids Tyrosine
Xenobiotics Styrene degradation
3 −0.709 0.0107 K01426 amidase [EC:3.5.1.4] Amino acids Phenylalanine, arginine and proline, tryptophan
Other amino acids Cyanoamino acid
Xenobiotics Styrene and aminobenzoate degradation
3 −0.728 0.042 K01580 glutamate decarboxylase [EC:4.1.1.15] Carbohydrate Butanoate
Amino acids Alanine, aspartate and glutamate metabolism
Other amino acids beta-alanine, taurine and hypotaurine
Metabolic diseasesh Type 1 diabetes mellitus
3 −0.833 0.0264 K01692 enoyl-CoA hydratase [EC:4.2.1.17] Carbohydrate Butanoate, propanoate
Lipid Fatty acid biosynthesis
Amino acids Tryptophan and/lysine, valine, leucine and isoleucine degradation
Other amino acids beta-alanine
Terpenoids and Polyketides Geraniol, limonene and pinene degradation
Xenobiotics Aminobenzoate, benzoate, and caprolactam degradation
3 −1.218 0.0134 K01907 acetoacetyl-CoA synthetase [EC:6.2.1.16] Carbohydrate Butanoate
Lipid Fatty acid biosynthesis
3 0.122 0.0377 K01963 acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2] Carbohydrate Propanoate
Energy Carbon fixation pathways in prokaryotes, methane
Lipid Fatty acid biosynthesis
Terpenoids and polyketides Tetracycline biosynthesis
3 −0.667 0.0386 K03781 catalase [EC:1.11.1.6] Neurodegenerativeh Amyotrophic lateral sclerosis
Transport and catabolismc Peroxisome
Amino acids Tryptophan
Energy Methane
3 −1.219 0.0331 K07516 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] Energy Carbon fixation pathways in prokaryotes, methane
Lipid Fatty acid biosynthesis
  1. *Values are the estimated log ratios of relative pathway abundances between the respective Day and Day 1. All pathways were designated as metabolic pathways unless otherwise designated by superscript: c = cellular processes, h = human disease