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Table 1 Mean ± standard deviation values of cardiorespiratory parameters, in dogs treated with ketamine (GK: bolus 0.5 mg kg−1; CRI 20 µg kg−1 min−1 in intra- and postoperative periods), fentanyl (GF: bolus 5 µg kg−1; intraoperative CRI 5 µg kg−1 h−1 and postoperative CRI 2 µg kg−1 h−1), or combination of ketamine-fentanyl (GKF: aforementioned doses) in intraoperative period

From: Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy

 

Anaesthesia (minutes)

Variable

Group

Baseline

5

15

25

35

45

55

65

75

HR

(beats minute−1)

GK

104 ± 13

129 ± 27

126 ± 32a

120 ± 42a

123 ± 33a

117 ± 22a

120 ± 16a

113 ± 16a

115 ± 13a

GKF

110 ± 22

87 ± 9

71 ± 8#b

69 ± 6#b

72 ± 16#b

66 ± 14#b

72 ± 24#b

75 ± 16#b

82 ± 16#b

GF

97 ± 35

113 ± 32

88 ± 25ab

57 ± 15#b

58 ± 10#a.b

71 ± 13b

68 ± 15#b

66 ± 11#b

69 ± 12#b

fR

(breaths minute−1)

GK

30 ± 10

17 ± 1#

17 ± 1#

16 ± 1#

15 ± 1#

15 ± 1#

16 ± 2#

16 ± 2#

16 ± 2#

GKF

34 ± 14

17 ± 2#

16 ± 1#

15 ± 2#

15 ± 1#

15 ± 1#

14 ± 3#

15 ± 1#

14 ± 3#

GF

28 ± 4#

20 ± 5#

14 ± 2

15 ± 3#

15 ± 4#

15 ± 2#

17 ± 2#

17 ± 1#

17 ± 1#

MAP

(mmHg)

GK

-

75 ± 14

70 ± 16

74 ± 13

90 ± 8a

81 ± 13

78 ± 10

77 ± 11

77 ± 9

GKF

-

74 ± 7

72 ± 9

60 ± 14

66 ± 10b

72 ± 12

76 ± 15

77 ± 6

79 ± 9

GF

-

73 ± 6

75 ± 8

73 ± 2

81 ± 15ab

89 ± 20

65 ± 40

87 ± 25

74 ± 10

SpO2

(%)

GK

-

99 ± 2

99 ± 2

99 ± 2

99 ± 1

99 ± 1

99 ± 1

99 ± 1

99 ± 2

GKF

-

98 ± 1

98 ± 1

97 ± 2

97 ± 2

97 ± 2

97 ± 1

97 ± 1

98 ± 1

GF

-

99 ± 1

99 ± 1

99 ± 1

99 ± 1

98 ± 2

98 ± 1

98 ± 1

98 ± 1

FE´CO2 (mmHg)

GK

-

36 ± 6

35 ± 6

34 ± 3

35 ± 4

34 ± 2

33 ± 5

34 ± 5

34 ± 5

GKF

-

27 ± 6

31 ± 1

31 ± 1

30 ± 3

32 ± 4

31 ± 2

32 ± 4

32 ± 5

GF

-

28 ± 2

30 ± 3

31 ± 4

33 ± 5

32 ± 4

33 ± 5

32 ± 5

31 ± 5

  1. a, b, c Significant difference between group. #Significant difference in treatment with a basal time point. HR Heart rate, fR respiratory rate, MAP mean arterial pressure, SpO2 pulse oximetry, FE’CO2 end-tidal carbon dioxide