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Table 8 Plasma parameter of buserelin after i.m. administration of 1 mg per pig and 3 mg per cow

From: The pharmacokinetics of buserelin after intramuscular administration in pigs and cows

Pharmacokinetic parameter

pigs

cows

tmax (h)

0.57 ± 0.18

1.05 ± 0.27

Cmax (ng/ml)

10.99 ± 2.04

2.68 ± 0.36

t1/2 (h)

1.29 ± 0.40

1.13 ± 0.30

AUC0-t (h × ng/ml)

25.02 ± 6.93

5.63 ± 1.86

AUC0-∞ (h × ng/ml)

25.75 ± 6.75

5.99 ± 2.01

Vd /F(L)

80.49 ± 43.88

839.88 ± 174.77

CL/F (L/h)

41.15 ± 11.18

545.04 ± 166.40

MRT0-t (h)

2.13 ± 0.27

1.85 ± 0.56

MRT0-∞ (h)

2.35 ± 0.23

2.16 ± 0.70

AUMClast(h × h × ng/mL)

59.59 ± 16.54

11.23 ± 6.89

Cmax/D(ng/mL/mg/kg)

610.19 ± 79.93

420.35 ± 58.40

ka(h−1)

0.48 ± 0.07

0.58 ± 0.17

  1. Abbreviation: tmax time to peak concentration, Cmax maximum plasma concentration, t1/2 elimination half-time, AUC0-t Area Under The Concentration–time curve from 0 to the last measurement point, AUC0-∞ Area Under The Concentration–time curve from 0 to infinity, Vd/F apparent Volume of distribution of Fraction absorbed, CL/F plasma Clearance of Fraction absorbed, MRT0-t Mean Residence Time from 0 to the last collection point, MRT0-∞ Mean Residence Time from 0 to infinity, AUMC the total Area Under The Moment Curve from the time of dosing to the last measurable concentration, Cmax/D the rate of Cmax to Dosage, ka absorption rate constant
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BMC Veterinary Research

ISSN: 1746-6148

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